Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness
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Cell fate decisions and pluripotency, but also malignancy depend on networks of key transcriptional regulators. The T-box transcription factor TBX3 has been implicated in the regulation of embryonic stem cell self-renewal and cardiogenesis. We have recently discovered that forced TBX3 expression in embryonic stem cells promotes mesendoderm specification directly by activating key lineage specification factors and indirectly by enhancing paracrine NODAL signalling. Interestingly, aberrant TBX3 expression is associated with breast cancer and melanoma formation. In other cancers, loss of TBX3 expression is associated with a more aggressive phenotype e.g. in gastric and cervical cancer. The precise function of TBX3 in pancreatic ductal adenocarcinoma remains to be determined. In the current study we provide conclusive evidence for TBX3 overexpression in pancreatic cancer samples as compared to healthy tissue. While proliferation remains unaltered, forced TBX3 expression strongly increases migration and invasion, but also angiogenesis in vitro and in vivo. Finally, we describe the TBX3-dependency of cancer stem cells that perpetuate themselves through an autocrine TBX3-ACTIVIN/NODAL signalling loop to sustain stemness. Thus, TBX3 is a new key player among pluripotency-related genes driving cancer formation.
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TBX3 can either promote tumor development or suppress tumor progression, depending on the tumor type.
“It has been reported TBX3 can either promote tumor development or suppress tumor progression, depending on the tumor type.[12, 21-24]”
From TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis (2021) · cites this paper as [22]
The Results (§3.4) show that TBX3 overexpression enlarges pancreatic tumors, supporting a tumor-promoting role. The Discussion (§4) reports that TBX3 can negatively regulate proliferation in some tumors, but also says it induces migration and invasion; it does not establish that TBX3 suppresses tumor progression in a particular tumor type. (LLM, conf=0.85)
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The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells
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TBX1 Functions as a Tumor Activator in Prostate Cancer by Promoting Ribosome RNA Gene Transcription
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TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration
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“Interestingly, TBX3 was associated with higher aggressiveness in pancreatic cancer via its ability to (i) promote angiogenesis and (ii) induce cancer stem cell properties [19].”
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TBX3 deficiency accelerates apoptosis in cardiomyoblasts through regulation of P21 expression
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TBX3 stimulates proliferation and stem cell self-renewal in bladder carcinoma.
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Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks
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Self-citationBiological effects of NODAL on endometrial cancer cells and its underlying mechanisms
Hong, X., Wen, B., Zhang, H., Li, Y., Wu, H., Zhao, W., & Luo, X. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9833 · Cited by 3 · see citing works
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Role of T-box transcription factor 3 in gastric cancers
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Non-coding mutations at enhancer clusters contribute to pancreatic ductal adenocarcinomaPreprint
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- Authors
- Perkhofer, L., Walter, K., Costa, I. G., Carrasco, M. C. R., Eiseler, T., Hafner, S., Genze, F., Zenke, M., Bergmann, W., Illing, A., Hohwieler, M., Köhntop, R., Lin, Q., Holzmann, K.-H., Seufferlein, T., Wagner, M., Liebau, S., Hermann, P. C., Kleger, A., & Müller, M.
- Affiliations
- Universität Ulm (DE)
- RWTH Aachen University (DE)
- University of Tübingen (DE)
- Corresponding author
- Hermann, Patrick C.
- Kleger, Alexander
- ORCID
- Venue
- Stem Cell Research
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 17
- Issue
- 2
- Pages
- 367-378
- ISSN
- 1873-5061 (ISSN-L)
- OpenAlex
- W2515869889
- Cited by
- 39
- References
- 68
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 9 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 3
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (2544/1-1 and 1-2)
- Forschungskern SyStaR
- Böhringer Ingelheim Ulm
- Else-Kröner-Fresenius-Stiftung (2011_A200)
- German Cancer Aid Max Eder Fellowship
- German Cancer Aid Grant (111879)
- Fritz-Thyssen Foundation (2015-00363)
- Hector Foundation Cancer Research Fund
- Baden-Württemberg Stiftung
- Interdisciplinary Center for Clinical Research (IZKF Aachen)
- RWTH Aachen University Medical School
- Else Kröner-Forschungskolleg Ulm
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- TBX3, pancreatic ductal adenocarcinoma, angiogenesis, cancer stem cells, stemness, cell migration and invasion, transcription factor overexpression, pluripotency genes
- MeSH terms
- AC133 Antigen, Adult, Aged, Aged, 80 and over, Cell Movement, Female, Humans, Male, Microscopy, Fluorescence, Middle Aged, Neovascularization, Pathologic, Pancreatic Neoplasms, Phenotype, Neoplastic Stem Cells, Apoptosis, Spheroids, Cellular, T-Box Domain Proteins, Activins, Cell Proliferation, Nodal Protein
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