Signal transducer and activator of transcription (STAT)-3 regulates microRNA gene expression in chronic lymphocytic leukemia cells
Open accessAbstract
Backgrounds: Approximately 1,000 microRNAs (miRs) are present in the human genome; however, little is known about the regulation of miR transcription. Because miR levels are deregulated in chronic lymphocytic leukemia (CLL) and signal transducer and activator of transcription (STAT)-3 is constitutively activated in CLL, we sought to determine whether STAT3 affects the transcription of miR genes in CLL cells. Methods: We used publically available data from the ENCODE project to identify putative STAT3 binding sites in the promoters of miR genes. Then we transfected CLL cells with STAT3-shRNA or with an empty vector, and to determine which miRs are differentially expressed, we used a miR microarray approach followed by validation of the microarray results for 6 miRs using quantitative real-time polymerase chain reaction (qRT-PCR). Results: We identified putative STAT3 binding sites in 160 promoter regions of 200 miRs, including miR-21, miR-29, and miR-155, whose levels have been reported to be upregulated in CLL. Levels of 72 miRs were downregulated (n = 63) or upregulated (n = 9). qRT-PCR confirmed the array data in 5 of 6 miRs. Conclusions: The presence of activated STAT3 has a profound effect on miR expression in CLL cells.
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Rozovski et al. identified putative STAT3 binding sites in the promoter region of 160 miRNA genes including MIR21.
“Rozouski et al. identified putative STAT3 binding sites in the promotor region of 160 miRNA genes including MIR21 [82].”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [82]
The Results and discussion section reports putative STAT3-binding sites in 160 promoter regions and identifies miR-21 among them. It specifies that those promoters correspond to 200 miR genes, not 160 miRNA genes. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe STAT3 transcription factor regulates microRNA gene expression.
“The STAT3 transcription factor also regulates microRNA gene expression.”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [82]
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Cites
1 retracted
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Melo, S. A., Ropero, S., Moutinho, C., Aaltonen, L. A., Yamamoto, H., Calin, G. A., Rossi, S., Fernández, A. F., Carneiro, F., Oliveíra, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.317 · Cited by 375 · see citing works
Self-citationRetractedMicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845 · see citing works
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 4,269 · see citing works
Self-citationmiRBase: integrating microRNA annotation and deep-sequencing data
Kozomara, A., & Griffiths-Jones, S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1027 · Cited by 3,042 · see citing works
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
Yu, H., Kortylewski, M., & Pardoll, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1995 · Cited by 1,809 · see citing works
Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031 · Cited by 1,739 · see citing works
A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
The ENCODE Project Consortium (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001046 · Cited by 1,495 · see citing works
Accumulation of miR-155 and BIC RNA in human B cell lymphomas
Eis, P. S., Tam, W., Sun, L., Chadburn, A., Li, Z., Gomez, M. F., Lund, E., & Dahlberg, J. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500613102 · Cited by 1,322 · see citing works
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias
Calin, G. A., Liu, C., Sevignani, C., Ferracin, M., Felli, N., Dumitru, C. D., Shimizu, M., Cimmino, A., Zupo, S., Dono, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404432101 · Cited by 1,279 · see citing works
Self-citationIliopoulos, D., Jaeger, S. A., Hirsch, H. A., Bulyk, M. L., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.023 · Cited by 830 · see citing works
ENCODE Project Writes Eulogy for Junk DNA
Pennisi, E. (2012) · Science · doi:10.1126/science.337.6099.1159 · Cited by 546 · see citing works
Emerging Roles for Natural MicroRNA Sponges
Ebert, M. S., & Sharp, P. A. (2010) · Current Biology · doi:10.1016/j.cub.2010.08.052 · Cited by 482 · see citing works
Fabbri, M., Bottoni, A., Shimizu, M., Spizzo, R., Nicoloso, M. S., Rossi, S., Barbarotto, E., Cimmino, A., Adair, B., Wojcik, S. E., et al. (2011) · JAMA · doi:10.1001/jama.2010.1919 · Cited by 294 · see citing works
Self-citationZhang, Q., Wang, H. Y., Marzec, M., Raghunath, P. N., Nagasawa, T., & Wasik, M. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501959102 · Cited by 263 · see citing works
Frank, D. A., Mahajan, S., & Ritz, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119869 · Cited by 238 · see citing works
Rossi, S., Shimizu, M., Barbarotto, E., Nicoloso, M. S., Dimitri, F., Sampath, D., Fabbri, M., Lerner, S. A., Barron, L. L., Rassenti, L. Z., et al. (2010) · Blood · doi:10.1182/blood-2010-01-263889 · Cited by 211 · see citing works
Self-citationHazan‐Halevy, I., Harris, D., Liu, Z., Liu, J., Li, P., Chen, X., Shanker, S., Ferrajoli, A., Keating, M. J., & Estrov, Z. E. (2010) · Blood · doi:10.1182/blood-2009-10-230060 · Cited by 199 · see citing works
Self-citationSampath, D., Liu, C., Vasan, K., Sulda, M. L., Puduvalli, V. K., Wierda, W. G., & Keating, M. J. (2011) · Blood · doi:10.1182/blood-2011-05-351510 · Cited by 196 · see citing works
Self-citationTimofeeva, O. A., Tarasova, N. I., Zhang, X., Chasovskikh, S., Cheema, A. K., Wang, H., Brown, M. L., & Dritschilo, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211805110 · Cited by 141 · see citing works
Baer, C. R., Claus, R., Frenzel, L. P., Zucknick, M., Park, Y. J., Gu, L., Weichenhan, D., Fischer, M., Pallasch, C. P., Herpel, E., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0803 · Cited by 136 · see citing works
Cell proliferation and death: Forgotten features of chronic lymphocytic leukemia B cells
Chiorazzi, N. (2007) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2007.03.007 · Cited by 122 · see citing works
MicroRNAs in chronic lymphocytic leukemia pathogenesis and disease subtypes
Mráz, M., Mráz, M., Pospı́šilová, Š., Malinová, K., Šlapák, I., & Mayer, J. (2009) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190902763517 · Cited by 106 · see citing works
Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming by Epigenetic Regulation
Tang, Y., Luo, Y., Jiang, Z., Ma, Y., Lin, C., Kim, C. G., Carter, M. G., Amano, T., Park, J., Kish, S. L., et al. (2012) · Stem Cells · doi:10.1002/stem.1225 · Cited by 82 · see citing works
STAT-3 Activates NF-κB in Chronic Lymphocytic Leukemia Cells
Liu, Z., Hazan‐Halevy, I., Harris, D., Li, P., Ferrajoli, A., Faderl, S., Keating, M. J., & Estrov, Z. E. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0559 · Cited by 67 · see citing works
Self-citationBueso-Ramos, C., Ferrajoli, A., Medeiros, L. J., Keating, M. J., & Estrov, Z. E. (2004) · Hematology · doi:10.1080/10245330410001727046 · Cited by 23 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis
Matsuyama, H., & Suzuki, H. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010132 · Cited by 246 · see citing works
Clinical significance of microRNAs in chronic and acute human leukemia
Yeh, C., Moles, R., & Nicot, C. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0518-2 · Cited by 153 · see citing works
Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions
Matsuhashi, S., Manirujjaman, M., Hamajima, H., & Ozaki, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092304 · Cited by 143 · see citing works
MicroRNA-21 in Glomerular Injury
Lai, J. Y., Luo, J., O'Connor, C. L., Jing, X., Nair, V., Ju, W., Randolph, A. E., Ben‐Dov, I. Z., Matar-Ujvary, R., Briskin, D., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013121274 · Cited by 139 · see citing works
Interplay between microRNAs and the STAT3 signaling pathway in human cancers
Cao, Q., Li, Y., He, W., Zhang, Z.-Z., Zhou, Q., Liu, X., Shen, Y., & Huang, T. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2013 · Cited by 104 · see citing works
Twaroski, D. M., Yan, Y., Olson, J. M. G., Bosnjak, Z. J., & Bai, X. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000345 · Cited by 89 · see citing works
MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2
Ruan, Q., Wang, P., Wang, T., Qi, J., Wei, M. H., Wang, S., Fan, T., Johnson, D., Wan, X., Shi, W., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.47 · Cited by 92 · see citing works
MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease
Lakhia, R., Hajarnis, S. S., Williams, D., Aboudehen, K., Yheskel, M., Xing, C., Hatley, M. E., Torres, V. E., Wallace, D. P., & Patel, V. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015060634 · Cited by 91 · see citing works
Fish, E. N., & Platanias, L. C. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0450 · Cited by 87 · see citing works
Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases
Melnik, B. C. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0746-z · Cited by 81 · see citing works
STAT3-activated CD36 facilitates fatty acid uptake in chronic lymphocytic leukemia cells
Rozovski, U., Harris, D., Li, P., Liu, Z., Jain, P., Ferrajoli, A., Burger, J. A., Thompson, P. A., Jain, N., Wierda, W. G., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25066 · Cited by 73 · see citing works
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Wang, G., Wang, J. J., Tang, H., & To, S. S. T. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.07.001 · Cited by 63 · see citing works
Singh, M., Garg, N., Venugopal, C., Hallett, R. M., Tokár, T., McFarlane, N. M., Mahendram, S., Bakhshinyan, D., Manoranjan, B., Vora, P., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4742 · Cited by 62 · see citing works
Pratheeshkumar, P., Son, Y., Divya, S. P., Turcios, L. M., Roy, R. V., Hitron, J. A., Wang, L., Kim, D., Dai, J., Asha, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9967 · Cited by 60 · see citing works
Zhao, J., Wang, X., Mi, Z., Jiang, X., Sun, L., Zheng, B., Wang, J., Meng, M., Zhang, L., Wang, Z., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03773-x · Cited by 59 · see citing works
Liu, J., Fei, D., Xing, J., & Du, J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.120 · Cited by 57 · see citing works
RetractedWP1066 sensitizes oral squamous cell carcinoma cells to cisplatin by targeting STAT3/miR-21 axis
Zhou, X., Ren, Y., Liu, A., Jin, R., Jiang, Q., Huang, Y., Kong, L., Wang, X., & Zhang, L. (2014) · Scientific Reports · doi:10.1038/srep07461 · Cited by 54 · see citing works
Wang, Y., Wang, S., Wu, Y., Ren, Y., Li, Z., Yao, X., Zhang, C., Ye, N., Jing, C., Dong, J., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0606 · Cited by 53 · see citing works
Epigenetic Field Cancerization in Gastric Cancer: microRNAs as Promising Biomarkers
Pereira, A. L., de Magalhães, L. L., Moreira, F. C., Reis-das-Mercês, L., Vidal, A. F., Ribeiro-dos-Santos, A. M., Demachki, S., Anaissi, A. K. M., Burbano, R. M. R., Albuquerque, P., et al. (2019) · Journal of Cancer · doi:10.7150/jca.27457 · Cited by 47 · see citing works
STAT3 is Overactivated in Gastric Cancer Stem-Like Cells.
Hajimoradi, M., Hassan, Z. M., Ebrahimi, M., Soleimani, M., Bakhshi, M., Firouzi, J., & Samani, F. S. (2016) · PubMed Central · doi:10.22074/cellj.2016.3834 · Cited by 46 · see citing works
Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis
Shahjahani, M., Asl, J. M., Norozi, F., Seghatoleslami, M., Shahrabi, S., Saba, F., & Saki, N. (2015) · Cellular Oncology · doi:10.1007/s13402-014-0215-3 · Cited by 45 · see citing works
Regulation of microRNA-1 (miR-1) expression in human cancer
Han, C., Shen, J. K., Hornicek, F. J., Kan, Q., & Duan, Z. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.12.004 · Cited by 44 · see citing works
miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis
Farooqı, A. A., Qureshi, M. Z., Coşkunpınar, E. M., Naqvi, S. K., Yaylım, İ., & Ismail, M. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.5.1909 · Cited by 43 · see citing works
Small molecule with big role: MicroRNAs in cancer metastatic microenvironments
Su, Y., Li, X., Ji, W., Sun, B., Xu, C., Li, Z., Qian, G., & Su, C. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.10.024 · Cited by 42 · see citing works
Katsaraki, K., Karousi, P., Artemaki, P. I., Scorilas, A., Pappa, V., Kontos, C. K., & Papageorgiou, S. G. (2021) · Cancers · doi:10.3390/cancers13040593 · Cited by 42 · see citing works
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Grzywnowicz, M., Karczmarczyk, A., Skórka, K., Zajac, M., Zaleska, J., Chocholska, S., Tomczak, W., & Giannopoulos, K. (2015) · Acta Haematologica · doi:10.1159/000430980 · Cited by 40 · see citing works
Shaim, H., Estrov, Z. E., Harris, D., Sanabria, M. H., Liu, Z., Ruvolo, P. P., Thompson, P. A., Ferrajoli, A., Daher, M., Burger, J. A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01773 · Cited by 38 · see citing works
Self-citationChen, X., Shi, J., Zhong, J., Huang, Z.-Y., Luo, X., Huang, Y., Feng, S., Shao, J., & Liu, D. (2015) · International Journal of Experimental Pathology · doi:10.1111/iep.12162 · Cited by 32 · see citing works
Di, J.-X., & Zhang, H. (2019) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000783 · Cited by 32 · see citing works
Dai, W., Liu, S., Zhang, J., Pei, M., Xiao, Y., Li, J., Hong, L., Lin, J., Wang, J., Wu, X., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.09.001 · Cited by 32 · see citing works
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Kaymaz, B. T., Günel, N. S., Ceyhan, M., Çetintaş, V. B., Özel, B., Yandım, M. K., Kıpçak, S., Aktan, Ç., Adan, A., Baran, Y., et al. (2015) · Tumor Biology · doi:10.1007/s13277-015-3509-9 · Cited by 29 · see citing works
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Ren, J. P., Wang, L., Zhao, J., Wang, L., Ning, S., Gazzar, M. E., Moorman, J. P., & Yao, Z. Q. (2016) · Immunology · doi:10.1111/imm.12680 · Cited by 24 · see citing works
Levidou, G., Sachanas, S. P., Pangalis, G. A., Kalpadakis, C. H., Yiakoumis, X., Moschogiannis, M., Sepsa, A., Lakiotaki, E., Milionis, V., Kyrtsonis, M., et al. (2014) · BioMed Research International · doi:10.1155/2014/251479 · Cited by 24 · see citing works
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Chen, N., Feng, L., Qu, H., Lu, K., Li, P., Lv, X., & Wang, X. (2018) · Oncology Reports · doi:10.3892/or.2018.6367 · Cited by 17 · see citing works
Self-citationQu, H.-O., Jiang, W., Wang, Y., & Chen, P. (2019) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
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- Authors
- Rozovski, U., Calin, G. A., Setoyama, T., D’Abundo, L., Harris, D. M., Li, P., Liu, Z., Grgurevic, S., Ferrajoli, A., Faderl, S., Burger, J. A., O’Brien, S., Wierda, W. G., Keating, M. J., & Estrov, Z.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Estrov, Zeev
- ORCID
- Venue
- Molecular Cancer
- Published
- 2013-06-01
- Volume
- 12
- Issue
- 1
- Pages
- 50-50
- ISSN
- 1476-4598 (ISSN-L)
- PMC
- PMC3671957
- OpenAlex
- W2110640276
- Semantic Scholar
- 8a6d0a469f75b32524772baeb914e561b18383ef
- Cited by
- 55
- References
- 26
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 4 · 2017: 3 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 2
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Cancer (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- National Institutes of Health (4p01ca081534-16)
- University of Texas MD Anderson Cancer Center ((CA016672), grant CA016672)
- National Cancer Institute (CA 016672, P30CA016672, P01-CA-081534)
- Topics
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- STAT3, microRNA expression, chronic lymphocytic leukemia, STAT3 binding sites, miR-21, miR-29, miR-155, transcriptional regulation, miRNA microarray
- MeSH terms
- Binding Sites, Humans, Promoter Regions, Genetic, Protein Binding, Signal Transduction, Leukemia, Lymphocytic, Chronic, B-Cell, Gene Expression Regulation, Leukemic, MicroRNAs, Cell Line, Tumor, STAT3 Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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