The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Potential role of miR-9 and miR-223 in recurrent ovarian cancer
Open accessAbstract
Background: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable disease. Results: Using real-time RT-PCR, we obtained distinct miRNA expression profiles between primary and recurrent serous papillary ovarian adenocarcinomas (n = 6) in a subset of samples previously used in a transcriptome approach. Expression levels of top dysregulated miRNA genes, miR-223 and miR-9, were examined using TaqMan PCR in independent cohorts of fresh frozen (n = 18) and FFPE serous ovarian tumours (n = 22). Concordance was observed on TaqMan analysis for miR-223 and miR-9 between the training cohort and the independent test cohorts. Target prediction analysis for the above miRNA "recurrent metastatic signature" identified genes previously validated in our transcriptome study. Common biological pathways well characterised in ovarian cancer were shared by miR-9 and miR-223 lists of predicted target genes. We provide strong evidence that miR-9 acts as a putative tumour suppressor gene in recurrent ovarian cancer. Components of the miRNA processing machinery, such as Dicer and Drosha are not responsible for miRNA deregulation in recurrent ovarian cancer, as deluded by TaqMan and immunohistochemistry. Conclusion: We propose a miRNA model for the molecular pathogenesis of recurrent ovarian cancer. Some of the differentially deregulated miRNAs identified correlate with our previous transcriptome findings. Based on integrated transcriptome and miRNA analysis, miR-9 and miR-223 can be of potential importance as biomarkers in recurrent ovarian cancer.
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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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MicroRNA Gene Expression Deregulation in Human Breast Cancer
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“This is also consistent with the very latest discovery that FGF signaling is crucial for collective invasion of carcinoma cells following the tracks generated by fibroblasts [43].”
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Cited by
Detection of Cancer with Serum miRNAs on an Oligonucleotide Microarray
Lodes, M. J., Caraballo, M., Suciu, D., Munro, S., Kumar, A., & Anderson, B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006229 · Cited by 406
Zhu, X., Shen, H., Yin, X., Yang, M., Wei, H., Chen, Q., Feng, F., Liu, Y., Xu, W., & Li, Y. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1095-1 · Cited by 374
Malzkorn, B., Wolter, M., Liesenberg, F., Grzendowski, M., Stühler, K., Meyer, H. E., & Reifenberger, G. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00328.x · Cited by 352
miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in Primary Breast Tumors
Enerly, E., Steinfeld, I., Kleivi, K., Leivonen, S.-K., Aure, M. R., Russnes, H. G., Rønneberg, J. A., Johnsen, H., Navon, R., Rødland, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016915 · Cited by 310
Burney, R. O., Hamilton, A. E., Aghajanova, L., Vo, K. C., Nezhat, C. N., Lessey, B. A., & Giudice, L. C. (2009) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gap068 · Cited by 254
Metadata
- Authors
- Laios, A., O'Toole, S., Flavin, R., Martin, C., Kelly, L., Ring, M., Finn, S. P., Barrett, C., Loda, M., Gleeson, N., D'Arcy, T., McGuinness, E., Sheils, O., Sheppard, B., & O' Leary, J.
- Venue
- Molecular Cancer
- Published
- 2008-04-28
- Volume
- 7
- Issue
- 1
- Pages
- 35-35
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2105312329
- Cited by
- 301
- References
- 4
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Laios, A., O'Toole, S., Flavin, R., Martin, C., Kelly, L., Ring, M., Finn, S. P., Barrett, C., Loda, M., Gleeson, N., D'Arcy, T., McGuinness, E., Sheils, O., Sheppard, B., & O' Leary, J. (2008). Potential role of miR-9 and miR-223 in recurrent ovarian cancer. Molecular Cancer. https://doi.org/10.1186/1476-4598-7-35
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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