MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis
Open accessAbstract
Endometriosis is a common gynecologic disorder characterized by pain and infertility. In addition to estrogen dependence, progesterone resistance is an emerging feature of this disorder. Specifically, a delayed transition from the proliferative to secretory phase as evidenced by dysregulation of progesterone target genes and maintenance of a proliferative molecular fingerprint in the early secretory endometrium (ESE) has been reported. MicroRNAs (miRNAs) are small noncoding RNAs that collectively represent a novel class of regulators of gene expression. In an effort to investigate further the observed progesterone resistance in the ESE of women with endometriosis, we conducted array-based, global miRNA profiling. We report distinct miRNA expression profiles in the ESE of women with versus without endometriosis in a subset of samples previously used in global gene expression analysis. Specifically, the miR-9 and miR-34 miRNA families evidenced dysregulation. Integration of the miRNA and gene expression profiles provides unique insights into the molecular basis of this enigmatic disorder and, possibly, the regulation of the proliferative phenotype during the early secretory phase of the menstrual cycle in affected women.
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The endometrium of women with endometriosis responds differently to ovarian hormones.
“It is important to emphasize that the endometrium of women with endometriosis has been documented to respond differently to ovarian hormones (83-86), and we can use this fact to discover new potential biomarkers through minimally invasive means (87).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [85]
Eutopic endometrium in women with moderate to severe endometriosis exhibits progesterone resistance, resulting in incomplete transition from proliferative to early secretory phase.
“Equally important is the characteristic progesterone resistance of eutopic endometrium in women with moderate to severe endometriosis, where the unresponsiveness to progesterone results in incomplete transition of the endometrium from proliferative to early secretory phase of uterine cycle (85).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [85]
A limiting factor hindering the exploration of miRNA as biomarkers in clinical trials is the small sample sizes of patients and lack of representation of all stages of endometriosis, stratified by menstrual stage.
“However, one limiting factor hindering the exploration of miRNA as biomarkers in clinical trials is the small sample sizes of patients and lack of representation of all stages of endometriosis, which are also stratified by menstrual stage (85, 109, 110).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [85]
Burney et al. discovered a potential functional relationship between decreased expression of miR-9 and miR-34 families in early secretory-phase eutopic endometrium of patients and their role in the delayed transition from proliferative to secretory phase in women with severe endometriosis.
“Burney et al., based on their previous transcriptomics analysis (27) and with the use of computational analysis, discovered a potential functional relationship between decreased expression of miR-9 and miR-34 families in early secretoryphase eutopic endometrium of patients and their role in the delayed transition from proliferative to secretory phase in women with severe endometriosis (85).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [85]
The study by [125] is limited by inclusion of control endometrium from women with coexisting intramural leiomyomata which could confound delineation of endometriosis-specific miRNA differences.
“Though strengthened by the stringency of including only surgically documented presence or absence of advanced stage endometriosis, the study is limited by inclusion of control endometrium from women with coexisting intramural leiomyomata which could confound delineation of endometriosis-specific miRNA differences.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [125]
In a parallel miRNA-mRNA array based comparison of three control early secretory phase endometrium (n = 3) with endometria from four women with moderate-severe endometriosis, six downregulated endometriosis associated miRNA were identified from the miR-9 and miR-34 miRNA families.
“In a parallel miRNA-mRNA array based comparison of three control early secretory phase endometrium (n = 3) with endometria from four women with moderate-severe endometriosis, six downregulated endometriosis associated miRNA were identified from the miR-9 and miR-34 miRNA families [125].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [125]
Relatively few studies have compared miRNA expression in eutopic endometrium from women with and without surgically confirmed endometriosis.
“In contrast to studies comparing miRNA expression in eutopic versus ectopic endometrium, relatively few studies have compared miRNA expression in eutopic endometrium from women with and without surgically confirmed endometriosis [120, 125, 126].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [125]
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- Authors
- Burney, R. O., Hamilton, A. E., Aghajanova, L., Vo, K. C., Nezhat, C. N., Lessey, B. A., & Giudice, L. C.
- Affiliations
- Madigan Army Medical Center (US)
- University of California, San Francisco (US)
- Venue
- MHR: Basic science of reproductive medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08-19
- Volume
- 15
- Issue
- 10
- Pages
- 625-631
- ISSN
- 1360-9947 (ISSN-L)
- 1460-2407
- PMC
- PMC2744474
- OpenAlex
- W2163150283
- Cited by
- 254
- References
- 27
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 11 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 22 · 2019: 15 · 2018: 21 · 2017: 19 · 2016: 20 · 2015: 18 · 2014: 15 · 2013: 20 · 2012: 12
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Human Reproduction (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD055764, U54HD035041, HD-35041-12)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, secretory endometrium, miRNA expression profiling, progesterone resistance, miR-9, miR-34, menstrual cycle, endometrial gene expression
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, MicroRNAs, Young Adult
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