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Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells

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Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

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Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB

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A central role for Stat3 in IL‐6‐induced regulation of growth and differentiation in M1 leukemia cells.

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Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction

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Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

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Autocrine IL-6 signaling: a key event in tumorigenesis?

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Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells.

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STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

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Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel Phosphatidylinositol 3-Kinase-dependent AKT/IκB Kinase α Pathway Targeting Activator Protein-1

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IL-6 Induces NF-κB Activation in the Intestinal Epithelia

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Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion

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Single and Combined Silencing of ERK1 and ERK2 Reveals Their Positive Contribution to Growth Signaling Depending on Their Expression Levels

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BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activityin Vivo

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Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype.

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Essential role of STAT3 in cytokine‐driven NF‐κB‐mediated serum amyloid A gene expression

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Interleukin-6-Specific Activation of the C/EBPδ Gene in Hepatocytes Is Mediated by Stat3 and Sp1

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Leptin-Induced IL-6 Production Is Mediated by Leptin Receptor, Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, Akt, NF-κB, and p300 Pathway in Microglia

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Activation of the Signal Transducers and Activators of the Transcription 3 Pathway in Alveolar Epithelial Cells Induces Inflammation and Adenocarcinomas in Mouse Lung

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Recombination Signal Sequence Binding Protein Jκ Is Constitutively Bound to the NF-κB Site of the Interleukin-6 Promoter and Acts as a Negative Regulatory Factor

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STAT3 Activation Regulates Growth, Inflammation, and Vascularization in a Mouse Model of Gastric Tumorigenesis

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Transcriptional Complex Formation of c-Fos, STAT3, and Hepatocyte NF-1α Is Essential for Cytokine-Driven C-Reactive Protein Gene Expression

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Interleukin-6-induced Tethering of STAT3 to the LAP/C/EBPβ Promoter Suggests a New Mechanism of Transcriptional Regulation by STAT3*

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Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non–Small Cell Lung Cancer

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Expression of Constitutively Active STAT3 Can Replicate the Cytokine-suppressive Activity of Interleukin-10 in Human Primary Macrophages

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Bone-derived SDF-1 stimulates IL-6 release via CXCR4, ERK and NF- B pathways and promotes osteoclastogenesis in human oral cancer cells

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IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s).

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Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells.

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Signal Transducers and Activators of Transcription 3 Augments the Transcriptional Activity of CCAAT/Enhancer-binding Protein α in Granulocyte Colony-stimulating Factor Signaling Pathway

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Glycogen synthase kinase-3 promotes the synergistic action of interferon-γ on lipopolysaccharide-induced IL-6 production in RAW264.7 cells

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STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression

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Amino Acid Residues Required for Physical and Cooperative Transcriptional Interaction of STAT3 and AP-1 Proteins c-Jun and c-Fos

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Synergistic Signaling by Corticotropin-Releasing Hormone and Leukemia Inhibitory Factor Bridged by Phosphorylated 3′,5′-Cyclic Adenosine Monophosphate Response Element Binding Protein at the Nur Response Element (NurRE)-Signal Transducers and Activators of Transcription (STAT) Element of the Proopiomelanocortin Promoter

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Cell Confluence-induced Activation of Signal Transducer and Activator of Transcription-3 (Stat3) Triggers Epithelial Dome Formation via Augmentation of Sodium Hydrogen Exchanger-3 (NHE3) Expression

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AG490, a Jak2-specific Inhibitor, Induces Osteoclast Survival by Activating the Akt and ERK Signaling Pathways

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Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: Different cytogenetic changes are correlated with genders and smoking habits

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Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent

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Construction of Simple and Efficient DNA Vector-Based Short Hairpin RNA Expression Systems for Specific Gene Silencing in Mammalian Cells

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STAT3-decoy ODN inhibits cytokine autocrine of murine tumor cells.

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Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro

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IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

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MSC-exosome: A novel cell-free therapy for cutaneous regeneration

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Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights

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MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

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Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

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Exosome-loaded hydrogels: A new cell-free therapeutic approach for skin regeneration

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EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction

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The role of inflammation in the pathogenesis of lung cancer

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SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophages

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MiR-125a promotes paclitaxel sensitivity in cervical cancer through altering STAT3 expression

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Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

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Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer

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Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

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HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition

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Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells

Mehta, R. R., Katta, H., Alimirah, F., Patel, R., Murillo, G., Peng, X., Muzzio, M., & Mehta, R. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065113 · Cited by 67 · see citing works

Interleukin-6 Cytokine: A Multifunctional Glycoprotein for Cancer

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Pyranocoumarins Isolated from Peucedanum praeruptorum Dunn Suppress Lipopolysaccharide-Induced Inflammatory Response in Murine Macrophages Through Inhibition of NF-κB and STAT3 Activation

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Early Secreted Antigenic Target of 6-kDa of Mycobacterium tuberculosis Stimulates IL-6 Production by Macrophages through Activation of STAT3

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JAK/STAT3 and NF-κB Signaling Pathways Regulate Cancer Stem-Cell Properties in Anaplastic Thyroid Cancer Cells

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Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification

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Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma: Possible association with PD-L1 expression

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Repeated muscle biopsies through a single skin incision do not elicit muscle signaling, but IL-6 mRNA and STAT3 phosphorylation increase in injured muscle

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Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma

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TRAIL receptors promote constitutive and inducible IL-8 secretion in non-small cell lung carcinoma

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JAK2/STAT3 Inhibition Attenuates Noise-Induced Hearing Loss

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Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6

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Sinomenine hydrochloride inhibits the progression of plasma cell mastitis by regulating IL-6/JAK2/STAT3 pathway

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miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation

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Chronic Stress Mediates Inflammatory Cytokines Alterations and Its Role in Tumorigenesis

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Decreased expression and activation of Stat3 in severe preeclampsia

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Resveratrol protects human nucleus pulposus cells from degeneration by blocking IL-6/JAK/STAT3 pathway

Wu, C., Ge, J., Yang, M., Yan, Q., Wang, Y., Yu, H., Yang, H., & Zou, J. (2021) · European journal of medical research · doi:10.1186/s40001-021-00555-1 · Cited by 35 · see citing works

Mechanical pain of the lower extremity after compression of the upper spinal cord involves signal transducer and activator of transcription 3-dependent reactive astrocytes and interleukin-6

Ono, T., Kohro, Y., Kohno, K., Tozaki‐Saitoh, H., Nakashima, Y., & Tsuda, M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.025 · Cited by 34 · see citing works

Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

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Prebiotic Potential and Anti-Inflammatory Activity of Soluble Polysaccharides Obtained from Soybean Residue

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JAK2 inhibition for the treatment of hematologic and solid malignancies

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Icariside II Induces Apoptosis of Melanoma Cells Through the Downregulation of Survival Pathways

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Tumor microenvironment profoundly modifies functional status of macrophages: Peritoneal and tumor-associated macrophages are two very different subpopulations

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Importance of IL-6 trans-signaling and high autocrine IL-6 production in human osteoarthritic chondrocyte metabolism

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Trinity of inflammation, innate immune cells and cross-talk of signalling pathways in tumour microenvironment

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Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer

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Vigna angularis inhibits IL-6-induced cellular signalling and ameliorates collagen-induced arthritis

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Inhibitory effects of Schisandrin�B on human prostate cancer cells

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Dysregulation of janus kinases and signal transducers and activators of transcription in cancer.

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Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells under hypoxia

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Hesperetin derivative-12 (HDND-12) regulates macrophage polarization by modulating JAK2/STAT3 signaling pathway

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Endothelial cells response to neutrophil-derived extracellular vesicles miRNAs in anti-PR3 positive vasculitis

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Determinants of the extent and duration of STAT3 signaling

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Phosphatase of regenerating liver-3 is regulated by signal transducer and activator of transcription 3 in acute myeloid leukemia

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Identification of novel small molecules that inhibit STAT3-dependent transcription and function

Kolosenko, I., Yu, Y., Busker, S., Dyczynski, M., Liu, J., Haraldsson, M., Palm‐Apergi, C., Helleday, T., Tamm, K. P., Page, B. D. G., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178844 · Cited by 23 · see citing works

Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status

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IL-6, IL-10, c-Jun and STAT3 expression in B-CLL

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Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ

Rehm, A., Gätjen, M., Gerlach, K., Scholz, F., Mensen, A., Gloger, M., Heinig, K., Lamprecht, B., Mathas, S., Bégay, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms6057 · Cited by 21 · see citing works

The decreased expression of Stat3 and p-Stat3 in preeclampsia-like rat placenta

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Long non‑coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin‑6/signal transducer and activator of transcription 3/Toll‑like receptor 4 axis

Huang, W., Huang, L., Wen, M., Fang, M., Deng, Y., & Zeng, H. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9559 · Cited by 19 · see citing works

Signal transducers and activators of transcription 3 function in lung cancer

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Therapy with JAK2 Inhibitors for Myeloproliferative Neoplasms

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MicroRNAs-mediated regulation pathways in rheumatic diseases

Assadiasl, S., Rajabinejad, M., Soleimanifar, N., Makiyan, F., Azizi, E., Rezaiemanesh, A., & Nicknam, M. H. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01097-6 · Cited by 15 · see citing works

Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction

Edelmann, S., Wiegand, A., Hentrich, T., Pasche, S., Schulze-Hentrich, J. M., Munk, M. H. J., Fallgatter, A. J., Kreifelts, B., & Nieratschker, V. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1125553 · Cited by 15 · see citing works

Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice

Woo, S., Choi, Y. K., KIM, A.-J., Yun, Y. J., Shin, Y. C., Cho, S., & Ko, S. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4889 · Cited by 15 · see citing works

The BK Channel Limits the Pro-Inflammatory Activity of Macrophages

Chen, Y., Markov, N., Gigon, L., Hosseini, A., Yousefi, S., Stojkov, D., & Simon, H. (2024) · Cells · doi:10.3390/cells13040322 · Cited by 12 · see citing works

Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells

Blaszczak, W., White, B., Monterisi, S., & Swietach, P. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113612 · Cited by 9 · see citing works

Autocrine Regulation of Interleukin-6 via the Activation of STAT3 and Akt in Cardiac Myxoma Cells

Jougasaki, M., Takenoshita, Y., Umebashi, K., Yamamoto, M., Sudou, K., Nakashima, H., Sonoda, M., & Kinjo, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042232 · Cited by 9 · see citing works

Association of Chronic Inflammation-Associated Cancer With Cytokines

Nakase, H., & Shimomori, Y. (2025) · Cureus · doi:10.7759/cureus.92239 · Cited by 8 · see citing works

Suppression of Platelet-Derived Growth Factor Receptor-Alpha Overcomes Resistance to Trastuzumab through STAT3-Dependent IL-6 Reduction in HER2-Positive Breast Cancer Cells

Kim, S., Kim, H., Jeong, Y., You, D., Yoon, S. Y., Lo, E., Nam, S. J., Lee, J. E., & Kim, S. W. (2023) · Biomedicines · doi:10.3390/biomedicines11030675 · Cited by 8 · see citing works

Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization

Tanabe, K. (2016) · Scientific Reports · doi:10.1038/srep25095 · Cited by 8 · see citing works

Enhanced activation of STAT3 in ascites-derived recurrent ovarian tumors: inhibition of cisplatin-induced STAT3 activation reduced tumorigenicity of ovarian cancer by a loss of cancer stem cell-like characteristics

Abubaker, K., Latifi, A., Chan, E., Luwor, R. B., Burns, C. J., Thompson, E. W., Findlay, J. K., & Ahmed, N. (2015) · Journal of Cancer Stem Cell Research · doi:10.14343/jcscr.2015.3e1001 · Cited by 7 · see citing works

Ginsenoside Re protects against kainate-induced neurotoxicity in mice by attenuating mitochondrial dysfunction through activation of the signal transducers and activators of transcription 3 signaling

Nguyen, Y. N. D., Jeong, J. H., Sharma, N., Tran, N. K. C., Tran, H.-Y. P., Dang, D., Park, J. H., Byun, J. K., Ko, S. K., Nah, S.-Y., et al. (2024) · Free Radical Research · doi:10.1080/10715762.2024.2341885 · Cited by 5 · see citing works

Runx1 activates the transformation of adipocytes into cancer-associated adipocytes by downregulating Plin1

Guo, B., Wang, K., Wu, J., Yu, H., Geng, C., Jin, Y., & Song, Y. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114573 · Cited by 4 · see citing works

MiRNA affects the advancement of breast cancer by modulating the immune system's response

Fu, Y., Yang, Q., Xu, N., & Zhang, X. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167759 · Cited by 4 · see citing works

Image-Based Profiling Can Discriminate the Effects of Inhibitors on Signaling Pathways under Differential Ligand Stimulation

Tanabe, K., Inagaki, A., Henmi, Y., & Satake, M. (2018) · SLAS DISCOVERY · doi:10.1177/2472555217751091 · Cited by 4 · see citing works

Engineered ATP-loaded extracellular vesicles: a dual-functional strategy for improving myocardial infarction therapy

Ansari, F. J., Behroozi, J., Chamanara, M., Shahrezaee, M., Shakerimoghaddam, A., Mousavi, S. H., Amanzadeh, A., Shokrgozar, M. A., Tafti, S. H. A., Ghorbani, M., et al. (2026) · Drug Delivery and Translational Research · doi:10.1007/s13346-026-02143-4 · Cited by 3 · see citing works

Targeted dermal delivery of phloretin via thermoresponsive nanoparticles potently suppresses STAT3/NF-κB-driven psoriatic inflammation

Lu, R., Zhao, R., Lian, P., Chen, G., Wang, R., Wazir, J., Ma, B., Gu, C., Pu, W., Li, L., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158267 · Cited by 3 · see citing works

Active substances and molecular mechanisms of Astragali Radix and Angelicae Sinensis radix against idiopathic pulmonary fibrosis effects by network pharmacology and in vitro experiments

Chu, H., Liu, S., Zhang, S., Wang, S., Hong-sheng, C., & Li, L. (2024) · Chinese Journal of Analytical Chemistry · doi:10.1016/j.cjac.2024.100397 · Cited by 3 · see citing works

SLC6A14 promotes cell migration and inhibits autophagy in gastric cancer by regulating JAK2/STAT3 signaling

Wang, H., & Wang, J. (2022) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v21i6.6 · Cited by 3 · see citing works

p27 specifically decreases in squamous carcinoma, and mediates NNK ‐induced transformation of human bronchial epithelial cells

Peng, M., Meng, H., Wang, J., Guo, M., Li, T., Qian, X., Chen, R., Jin, H., & Huang, C. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18577 · Cited by 2 · see citing works

Identification of Potential Targets for EGFR-Regulated Nucleus Pulposus Degeneration Using Single-Cell RNA Sequencing and Machine Learning

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Development of the CK‐MB‐1 trastuzumab‐resistant HER2‐positive breast cancer cell line and xenograft animal models

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Tim-3 promotes cell aggressiveness and paclitaxel resistance through the NF-κB /STAT3 signaling pathway in breast cancerPreprint

Cong, Y., Cui, Y., Zhu, S., Cao, J., Qiao, G., Zou, H., Jiang, W. G., & Yu, Z. (2020) · doi:10.21203/rs.2.22315/v2 · Cited by 1 · see citing works

IL-6 as a Potential Biomarker in Lung Cancer

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Discovery of a novel miconazole analogue as a dual apo-IDO1 inhibitor and ABCB1 modulator for cancer immunotherapy and chemosensitizing

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STAT3 positively regulates IL-6 expression in lung cancer cells

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Autocrine IL-6在腫瘤細胞發生的機制和生物學上扮演的角色：側重於與腫瘤抗藥性相關之研究

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STAT3, but not ERKs, mediates the IL-6–induced proliferation of renal cancer cells, ACHN and 769P

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2.46 Signal Transducer and Activator of Transcription 3 and Nuclear Factor κB Activation Regulate Autocrine Interleukin-6 Production and Indicate the Prognosis of CLL

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Open Access

Huang, W.-L., Yeh, H.-H., Lin, C.-C., Lai, W.-W., Chang, J.-Y., Chang, W.-T., & Su, W.-C. (2013)