Conjugated linoleic acid content of human plasma
Open accessAbstract
Conjugated linoleic acid (CLA), a naturally occurring anticarcinogen found in dairy products, is an intermediary product of ruminal biohydrogenation of polyunsaturated fatty acids. Few data exist on the CLA content of the human blood plasma. The determination of a "normal" content could help in estimating if a person consumes satisfactory amounts of CLA with the diet and thus takes advantage of its potential beneficial effects on health. The purpose of this study was to compare the plasma CLA content of individuals not consuming dairy products (group 1, n = 12), individuals consuming normal amounts of dairy products (group 2, n = 77) and individuals consuming CLA supplement (group 3, n = 12). The only CLA isomer that presented higher percentage than the detection limit (0.03% of total fatty acids) was rumenic acid (cis9, trans11-octadecadienoic acid). An interesting finding is that compared to the other two groups, group 3 members show the highest average plasma content in rumenic acid, i.e. 0.20% of total fatty acids. The present study could be characterized as the first step in the direction of establishing a normal CLA content of human plasma. Based on these results, it could be suggested that the lower limit of the plasma CLA content is approximately 0.1% of total fatty acids.
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There will be a preferential reaction of NO2 with CLA rather than bis-allylic dienes even when conjugated dienes are present in approximately 100-fold lower concentrations than other bis-allylic unsaturated fatty acids in plasma.
“In carbon tetrachloride, the conjugated diene 2,5-dimethyl-2,4-hexadiene is 10 4 -10 6 more reactive than monoalkenes (40), reinforcing that there will be a preferential reaction of ⅐ NO 2 with CLA rather than bis-allylic dienes, even when conjugated dienes are present in ϳ100-fold lower concentrations than other bis-allylic unsaturated fatty acids in plasma (41).”
From Conjugated linoleic acid is a preferential substrate for fatty acid nitration (2012) · cites this paper as [41]
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- Authors
- Zlatanos, S. N., Laskaridis, K., & Sagredos, A.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Corresponding author
- Zlatanos, Spiros N
- Venue
- Lipids in Health and Disease
- Published
- 2008
- Volume
- 7
- Issue
- 1
- Pages
- 34
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC2565665
- OpenAlex
- W2154754310
- Cited by
- 47
- References
- 26
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- conjugated linoleic acid, plasma fatty acids, rumenic acid, dairy products, ruminal biohydrogenation, polyunsaturated fatty acids, reference values, anticarcinogens
- MeSH terms
- Dairy Products, Fatty Acids, Humans, Dietary Supplements, Linoleic Acids, Conjugated
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