Linking the Tinnitus Questionnaire and the subjective Clinical Global Impression: Which differences are clinically important?
Open accessAbstract
BACKGROUND: Development of new tinnitus treatments requires prospective placebo-controlled randomized trials to prove their efficacy. The Tinnitus Questionnaire (TQ) is a validated and commonly used instrument for assessment of tinnitus severity and has been used in many clinical studies. Defining the Minimal Clinically Important Difference (MCID) for TQ changes is an important step to a better interpretation of the clinical relevance of changes observed in clinical trials. In this study we aimed to estimate the minimum change of the TQ score that could be considered clinically relevant. METHODS: 757 patients with chronic tinnitus were pooled from the TRI database and the RESET study. An anchor-based approach using the Clinical Global Impression (CGI) scale and distributional approaches were used to estimate MCID. Receiver Operating Characteristic (ROC) curves were calculated to define optimal TQ change cutoffs discriminating between minimally changed and unchanged subjects. RESULTS: The relationship between TQ change scores and CGI ratings of change was good (r = 0.52, p < 0.05). Mean change scores associated with minimally better and minimally worse CGI categories were -6.65 and +2.72 respectively. According to the ROC method MCID for improvement was -5 points and for deterioration +1 points. CONCLUSION: Distribution and anchor-based methods yielded comparable results in identifying MCIDs. ΔTQ scores of -5 and +1 points were identified as the minimal clinically relevant change for improvement and worsening respectively. The asymmetry of the MCIDs for improvement and worsening may be related to expectation effects.
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Within the intervention group, the observed improvement in TQ score exceeded the minimal clinically important difference of -6.65.
“Within the intervention group the observed improvement of TQ Score by use of the Tinnitus app exceeded the MCID of -6.65 reported by a study linking TQ Scores and clinical global expression [17].”
From Randomized controlled trial of a smartphone-based cognitive behavioral therapy for chronic tinnitus (2023) · cites this paper as [17]
The Results report −6.65 as the mean TQ change among patients who rated themselves minimally better. But the Discussion and Conclusions identify approximately −5 points, not −6.65, as the recommended MCID for improvement. The app group's observed improvement is the citing study's own finding, not a finding attributed to this source. (LLM, conf=0.88)
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The Effectiveness of Online Feldenkrais Lessons on Somatosensory Tinnitus - A Pilot StudyPreprint
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- Authors
- Adamchic, I., Tass, P., Langguth, B., Hauptmann, C., Koller, M., Schecklmann, M., Zeman, F., & Landgrebe, M.
- Affiliations
- Forschungszentrum Jülich (DE)
- University of Regensburg (DE)
- University Hospital Regensburg (DE)
- Sozialstiftung Bamberg (DE)
- Corresponding author
- Adamchic, Ilya
- ORCID
- Venue
- Health and Quality of Life Outcomes
- Published
- 2012
- Volume
- 10
- Issue
- 1
- Pages
- 79
- ISSN
- 1477-7525 (ISSN-L)
- PMC
- PMC3487915
- OpenAlex
- W2135498452
- Cited by
- 79
- References
- 56
- Citations by year
- 2025: 5 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 4 · 2012: 4
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Health and Quality of Life Outcomes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Keywords
- tinnitus, Tinnitus Questionnaire, minimal clinically important difference, chronic tinnitus, Clinical Global Impression Scale, anchor-based estimation, distributional methods, expectancy effects
- MeSH terms
- Female, Humans, Male, Surveys and Questionnaires, Tinnitus
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