The DOI matches its Crossref record; 234 of the 234 references it cites were found in a registry or an index.
SF-1 a key player in the development and differentiation of steroidogenic tissues
Open accessAbstract
Since its discovery in the early 1990s, the orphan nuclear receptor SF-1 has been attributed a central role in the development and differentiation of steroidogenic tissues. SF-1 controls the expression of all the steroidogenic enzymes and cholesterol transporters required for steroidogenesis as well as the expression of steroidogenesis-stimulating hormones and their cognate receptors. SF-1 is also an essential regulator of genes involved in the sex determination cascade. The study of SF-1 null mice and of human mutants has been of great value to demonstrate the essential role of this factor in vivo, although the complete adrenal and gonadal agenesis in knock-out animals has impeded studies of its function as a transcriptional regulator. In particular, the role of SF-1 in the hormonal responsiveness of steroidogenic genes promoters is still a subject of debate. This extensive review takes into account recent data obtained from SF-1 haploinsufficient mice, pituitary-specific knock-outs and from transgenic mice experiments carried out with SF-1 target gene promoters. It also summarizes the pros and cons regarding the presumed role of SF-1 in cAMP signalling.
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Cites
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Cited by
Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage
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Ragazzon, B., Lefrançois-Martinez, A.-M., Val, P., Sahut-Barnola, I., Tournaire, C., Chambon, C., Gachancard-Bouya, J.-L., Begue, R.-J., Veyssière, G., & Martinez, A. (2006) · Endocrinology · doi:10.1210/en.2005-1279 · Cited by 67
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Metadata
- Authors
- Val, P., Lefrançois-Martinez, A.-M., Veyssière, G., & Martinez, A.
- Venue
- Nuclear Receptor
- Published
- 2003-09-18
- Volume
- 1
- Issue
- 1
- Pages
- 8-8
- ISSN
- 1478-1336 (ISSN-L)
- OpenAlex
- W2152741970
- Cited by
- 257
- References
- 234
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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