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Orphan Nuclear Receptors: From Gene to Function*

Giguère, Vincent·1999·Endocrine Reviews
DOI 10.1210/edrv.20.5.0378
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Abstract

I. Introduction II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of action III. Orphan Nuclear Receptors A. Definition B. Nomenclature C. Structural and functional diversity IV. Novel Hormone Response Systems: RXR and Its Heterodimeric Partners A. RXR: rexinoids B. PPAR: multiple ligands, multiple functions C. PXR: pregnanes, xenobiotic compounds, and benzoate derivatives D. CAR (constitutive androstane receptor): androstanes and phenobarbital E. LXR: control of cholesterol metabolism by oxysterols F. FXR: bile acids receptor V. Orphans in Search of a Home A. HNF4: diabetes and possible regulation by acyl-coenzyme A (CoA) thioesters B. FTZ-F1: steroidogenesis and sexual development C. Rev-Erb: singular members of the superfamily D. ROR: neuron development and T cell selection E. TR2: the testis receptors F. TLX: forebrain development G. COUP-TF: neurogenesis, angiogenesis, and heart development H. ERR: placenta development and control of lipid metabolism I. NGFI-B: hyp...

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Metadata

Authors
Giguère, V.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
1999-10-01
Volume
20
Issue
5
Pages
689-725
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv.20.5.0378
OpenAlex
W1969839676
Cited by
855
References
33
FWCI
14.21
Type
journal article
Language
en
Open access
closed

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