The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential
Open accessAbstract
BACKGROUND: Several studies demonstrate the role of adipose mesenchymal stem cells (ASCs) in angiogenesis. The angiogenic mechanism has been ascribed to paracrine factors since these cells secrete a plenty of signal molecules and growth factors. Recently it has been suggested that besides soluble factors, extracellular vesicles (EVs) that include exosomes and microvesicles may play a major role in cell-to-cell communication. It has been shown that EVs are implicated in the angiogenic process. RESULTS: Herein we studied whether EVs released by ASCs may mediate the angiogenic activity of these cells. Our results demonstrated that ASC-derived EVs induced in vitro vessel-like structure formation by human microvascular endothelial cells (HMEC). EV-stimulated HMEC when injected subcutaneously within Matrigel in SCID mice formed vessels. Treatment of ASCs with platelet-derived growth factor (PDGF) stimulated the secretion of EVs, changed their protein composition and enhanced the angiogenic potential. At variance of EVs released in basal conditions, PDGF-EVs carried c-kit and SCF that played a role in angiogenesis as specific blocking antibodies inhibited in vitro vessel-like structure formation. The enhanced content of matrix metalloproteinases in PDGF-EVs may also account for their angiogenic activity. CONCLUSIONS: Our findings indicate that EVs released by ASCs may contribute to the ASC-induced angiogenesis and suggest that PDGF may trigger the release of EVs with an enhanced angiogenic potential.
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Cites
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Cited by
Korniluk, A., Koper-Lenkiewicz, O. M., Kamińska, J., Kemona, H., & Dymicka-Piekarska, V. (2019) · Mediators of Inflammation · doi:10.1155/2019/9213074 · Cited by 577
Busatto, S., Vilanilam, G., Ticer, T., Lin, W.-L., Dickson, D. W., Shapiro, S., Bergese, P., & Wolfram, J. (2018) · Cells · doi:10.3390/cells7120273 · Cited by 532
Guo, S.-C., Tao, S.-C., Yin, W.-J., Qi, X., Yuan, T., & Zhang, C.-Q. (2017) · Theranostics · doi:10.7150/thno.16803 · Cited by 513
Brennan, M. Á., Layrolle, P., & Mooney, D. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909125 · Cited by 396
Extracellular Vesicles: Potential Roles in Regenerative Medicine
De Jong, O. G., Van Balkom, B. W. M., Schiffelers, R. M., Bouten, C. V. C., & Verhaar, M. C. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00608 · Cited by 351
Metadata
- Authors
- Lopatina, T., Bruno, S., Tetta, C., Kalinina, N., Porta, M., & Camussi, G.
- Venue
- Cell Communication and Signaling
- Published
- 2014-04-11
- Volume
- 12
- Issue
- 1
- Pages
- 26-26
- ISSN
- 1478-811X (ISSN-L)
- OpenAlex
- W2168092468
- Cited by
- 309
- References
- 56
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lopatina, T., Bruno, S., Tetta, C., Kalinina, N., Porta, M., & Camussi, G. (2014). Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential. Cell Communication and Signaling. https://doi.org/10.1186/1478-811x-12-26
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