The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cooperation and virulence in acute Pseudomonas aeruginosainfections
Open accessAbstract
BACKGROUND: Efficient host exploitation by parasites is frequently likely to depend on cooperative behaviour. Under these conditions, mixed-strain infections are predicted to show lower virulence (host mortality) than are single-clone infections, due to competition favouring non-contributing social 'cheats' whose presence will reduce within-host growth. We tested this hypothesis using the cooperative production of iron-scavenging siderophores by the pathogenic bacterium Pseudomonas aeruginosa in an insect host. RESULTS: We found that infection by siderophore-producing bacteria (cooperators) results in more rapid host death than does infection by non-producers (cheats), and that mixtures of both result in intermediate levels of virulence. Within-host bacterial growth rates exhibited the same pattern. Crucially, cheats were more successful in mixed infections compared with single-clone infections, while the opposite was true of cooperators. CONCLUSION: These data demonstrate that mixed clone infections can favour the evolution of social cheats, and thus decrease virulence when parasite growth is dependent on cooperative behaviours.
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Cites
The genetical evolution of social behaviour. I
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Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Iron Metabolism in Pathogenic Bacteria
Ratledge, C., & Dover, L. G. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.881 · Cited by 1,539
Cooperation and competition in pathogenic bacteria
Griffin, A. S., West, S. A., & Buckling, A. (2004) · Nature · doi:10.1038/nature02744 · Cited by 1,104
Self-citationGuerinot, M. L. (1994) · Annual Review of Microbiology · doi:10.1146/annurev.mi.48.100194.003523 · Cited by 664
Cited by
Bacterial siderophores in community and host interactions
Kramer, J., Özkaya, Ö., & Kümmerli, R. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0284-4 · Cited by 998
Targeting virulence: can we make evolution-proof drugs?
Allen, R. C., Popat, R., Diggle, S. P., & Brown, S. P. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3232 · Cited by 532
Parasite adaptations to within-host competition
Mideo, N. (2009) · Trends in Parasitology · doi:10.1016/j.pt.2009.03.001 · Cited by 266
Ryall, B., Eydallin, G., & Ferenci, T. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05028-11 · Cited by 160
Gallium-mediated siderophore quenching as an evolutionarily robust antibacterial treatment
Ross-Gillespie, A., Weigert, M., Brown, S. P., & Kümmerli, R. (2014) · Evolution, Medicine, and Public Health · doi:10.1093/emph/eou003 · Cited by 104
Metadata
- Authors
- Harrison, F., Browning, L. E., Vos, M., & Buckling, A.
- Venue
- BMC Biology
- Published
- 2006-07-07
- Volume
- 4
- Issue
- 1
- Pages
- 21-21
- ISSN
- 1741-7007 (ISSN-L)
- OpenAlex
- W2122962619
- Cited by
- 196
- References
- 5
- FWCI
- 39.19
- Type
- journal article
- Language
- en
- Open access
- gold
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