Multigenerational epigenetic effects of nicotine on lung function
Open accessAbstract
A recent preclinical study has shown that not only maternal smoking but also grandmaternal smoking is associated with elevated pediatric asthma risk. Using a well-established rat model of in utero nicotine exposure, Rehan et al. have now demonstrated multigenerational effects of nicotine that could explain this 'grandmother effect'. F1 offspring of nicotine-treated pregnant rats exhibited asthma-like changes to lung function and associated epigenetic changes to DNA and histones in both lungs and gonads. These alterations were blocked by co-administration of the peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, implicating downregulation of this receptor in the nicotine effects. F2 offspring of F1 mated animals exhibited similar changes in lung function to that of their parents, even though they had never been exposed to nicotine. Thus epigenetic mechanisms appear to underlie the multigenerational transmission of a nicotine-induced asthma-like phenotype. These findings emphasize the need for more effective smoking cessation strategies during pregnancy, and cast further doubt on the safety of using nicotine replacement therapy to reduce tobacco use in pregnant women.Please see related article: http://www.biomedcentral.com/1741-7015/10/129.
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Fetal nicotine exposure has transgenerational epigenetic effects on lung function.
“Recent evidence has been provided for transgenerational epigenetic effects of fetal nicotine exposure on lung function, suggesting that nicotine can create lasting, multigenerational alterations in the epigenome (Rehan et al. 2012; Leslie, 2013).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Leslie, 2013
The Transgenerational transmission section reports epigenetic changes in F1 rats and altered lung function in F2 rats after prenatal nicotine exposure. It also says F2 germ-cell epigenetic changes were not examined and that lung-function studies in F3 and F4 are needed to establish true transgenerational inheritance. Thus the evidence supports multigenerational lung effects, but not established lasting, transgenerational alterations of the epigenome. (LLM, conf=0.87)
Experimental — accuracy not yet measuredNicotine can create lasting, multigenerational alterations in the epigenome.
“Recent evidence has been provided for transgenerational epigenetic effects of fetal nicotine exposure on lung function, suggesting that nicotine can create lasting, multigenerational alterations in the epigenome (Rehan et al. 2012; Leslie, 2013).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Leslie, 2013
The Transgenerational transmission section reports epigenetic changes in F1 rats and altered lung function in F2 rats. It says F2 germ-cell epigenetic changes were not examined, so the evidence supports multigenerational effects but does not establish lasting, multigenerational alterations in the epigenome. (LLM, conf=0.86)
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- Authors
- Leslie, F. M.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Leslie, Frances M
- ORCID
- Leslie, Frances M
- Venue
- BMC Medicine
- Published
- 2013-02-04
- Volume
- 11
- Issue
- 1
- Pages
- 27-27
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC3585797
- OpenAlex
- W2080331370
- Cited by
- 67
- References
- 15
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 16 · 2015: 10 · 2014: 6 · 2013: 2
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- nicotine, maternal smoking, lung function, asthma, DNA methylation, histone modifications, PPARγ, rosiglitazone, nicotine replacement therapy, smoking cessation during pregnancy, gonads
- MeSH terms
- Animals, Asthma, Female, Fetus, Male, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects
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