Cited by 127Treatment of Major DepressionStress Responses and CortisolTryptophan and brain disorders

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Depression pathogenesis and treatment: what can we learn from blood mRNA expression?

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Hepgul, Nilay, Cattaneo, Annamaria, Zunszain, Patricia A, Pariante, Carmine M·2013·BMC Medicine

DOI 10.1186/1741-7015-11-28PMC PMC3606439

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Abstract

Alterations in several biological systems, including the neuroendocrine and immune systems, have been consistently demonstrated in patients with major depressive disorder. These alterations have been predominantly studied using easily accessible systems such as blood and saliva. In recent years there has been an increasing body of evidence supporting the use of peripheral blood gene expression to investigate the pathogenesis of depression, and to identify relevant biomarkers. In this paper we review the current literature on gene expression alterations in depression, focusing in particular on three important and interlinked biological domains: inflammation, glucocorticoid receptor functionality and neuroplasticity. We also briefly review the few existing transcriptomics studies. Our review summarizes data showing that patients with major depressive disorder exhibit an altered pattern of expression in several genes belonging to these three biological domains when compared with healthy controls. In particular, we show evidence for a pattern of 'state-related' gene expression changes that are normalized either by remission or by antidepressant treatment. Taken together, these findings highlight the use of peripheral blood gene expression as a clinically relevant biomarker approach.

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Authors: Hepgul, N., Cattaneo, A., Zunszain, P. A., & Pariante, C. M.
Affiliations: King's College London (GB)
Corresponding author: Pariante, Carmine M
ORCID: Hepgul, Nilay
Cattaneo, Annamaria
Zunszain, Patricia A
Pariante, Carmine M
Venue: BMC Medicine
Publisher: Springer Science and Business Media LLC
Published: 2013-02-05
Volume: 11
Issue: 1
Pages: 28-28
ISSN: 1741-7015 (ISSN-L)
DOI: 10.1186/1741-7015-11-28
PMC: PMC3606439
OpenAlex: W2030900581
Cited by: 127
References: 86
Citations by year: 2026: 4 · 2025: 3 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 11 · 2016: 17 · 2015: 12 · 2014: 11 · 2013: 5
FWCI: 1.89
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.springer.com/tdm (unspecified)
Locations: BMC Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion, other-oa)
Funders: South London and Maudsley NHS Foundation Trust (MR/J002739/1)
National Alliance for Research on Schizophrenia and Depression
Psychiatry Research Trust
National Institute for Health and Care Research (MR/J002739/1)
King's College London
Medical Research Council (MR/J002739/1)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, depression pathogenesis, peripheral blood gene expression, biomarkers, inflammation, glucocorticoid receptor, neuroplasticity, transcriptomics, antidepressant response, remission, neuroendocrine system, immune system
MeSH terms: Depression, Humans, Inflammation, Neuronal Plasticity, Receptors, Glucocorticoid, Microarray Analysis, Transcriptome

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