Early life trauma, depression and the glucocorticoid receptor gene—An epigenetic perspective

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · see citing works

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124 · see citing works

Research domain criteria (RDoC): toward a new classification framework for research on mental disorders

Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067 · see citing works

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works

Resilience in the Face of Adversity

Rutter, M. (1985) · British Journal of Psychiatry · doi:10.1192/bjp.147.6.598 · Cited by 3,616 · see citing works

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works

Genetic Epidemiology of Major Depression: Review and Meta-Analysis

Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works

Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress

Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170 · see citing works

DNA methylation: roles in mammalian development

Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045 · see citing works

Perceptions of epigenetics

Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011 · see citing works

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works

Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations

Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · see citing works

The Corticosteroid Receptor Hypothesis of Depression

Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works

DNA Methylation and Gene Function

Razin, A., & Riggs, A. D. (1980) · Science · doi:10.1126/science.6254144 · Cited by 2,076 · see citing works

Grand challenges in global mental health

Collins, P. Y., Patel, V., Joestl, S. S., March, D., Insel, T. R., Daar, A. S., Bordin, I. A., Costello, E. J., Durkin, M., Fairburn, C., et al. (2011) · Nature · doi:10.1038/475027a · Cited by 2,043 · see citing works

The HPA axis in major depression: classical theories and new developments

Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009 · see citing works

DNA Modification Mechanisms and Gene Activity During Development

Holliday, R., & Pugh, J. E. (1975) · Science · doi:10.1126/science.187.4173.226 · Cited by 1,973 · see citing works

Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat

Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965 · see citing works

Stability and flexibility of epigenetic gene regulation in mammalian development

Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963 · see citing works

Defining the role of common variation in the genomic and biological architecture of adult human height

The Electronic Medical Records and Genomics (eMERGE) Consortium, Wood, A. R., The MIGen Consortium, The PAGE Consortium, Study, T. L. C., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.3097 · Cited by 1,853 · see citing works

Personal genomes: The case of the missing heritability

Maher, B. (2008) · Nature · doi:10.1038/456018a · Cited by 1,737 · see citing works

The link between childhood trauma and depression: insights from HPA axis studies in humans

Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704 · see citing works

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

Oberlander, T. F., Weinberg, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008) · Epigenetics · doi:10.4161/epi.3.2.6034 · Cited by 1,432 · see citing works

Association of <emph type="ital">FKBP5</emph> Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362 · see citing works

X inactivation, differentiation, and DNA methylation

Riggs, A. D. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000130315 · Cited by 1,343 · see citing works

Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women: An Epidemiological and Cotwin Control Analysis

Kendler, K. S., Bulik, C. M., Silberg, J., Hettema, J. M., Myers, J., & Prescott, C. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.953 · Cited by 1,259 · see citing works

How Are Alkynes Scrambled?

Bunz, U. H. F. (2005) · Science · doi:10.1126/science.1111098 · Cited by 1,252 · see citing works

Dynamic DNA methylation programs persistent adverse effects of early-life stress

Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works

Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment

Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works

A mega-analysis of genome-wide association studies for major depressive disorder

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works

A Prospective Investigation of Major Depressive Disorder and Comorbidity in Abused and Neglected Children Grown Up

Spatz Widom, C., DuMont, K., & Czaja, S. J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.49 · Cited by 1,059 · see citing works

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977 · see citing works

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

Binder, E. B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.021 · Cited by 968 · see citing works

Early Life Programming and Neurodevelopmental Disorders

Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961 · see citing works

Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome

Meaney, M. J., & Szyf, M. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.2/mmeaney · Cited by 958 · see citing works

The impact of child sexual abuse on health: a systematic review of reviews

Maniglio, R. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.08.003 · Cited by 887 · see citing works

Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60

Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M. (2010) · Developmental Neuroscience · doi:10.1159/000111395 · Cited by 878 · see citing works

Beyond DNA: integrating inclusive inheritance into an extended theory of evolution

Danchin, É., Charmantier, A., Champagne, F. A., Mesoudi, A., Pujol, B., & Blanchet, S. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3028 · Cited by 860 · see citing works

Effects of the social environment and stress on glucocorticoid receptor gene methylation: A systematic review

Turecki, G., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.022 · Cited by 796 · see citing works

A Swedish National Twin Study of Lifetime Major Depression

Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.109 · Cited by 794 · see citing works

THE QUANTITATIVE SEPARATION OF PURINES, PYRIMIDINES, AND NUCLEOSIDES BY PAPER CHROMATOGRAPHY

Hotchkiss, R. D. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57261-6 · Cited by 765 · see citing works

The Genetics of Major Depression

Flint, J., & Kendler, K. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.027 · Cited by 724 · see citing works

Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients

Raadsheer, F. C., Hoogendijk, W. J. G., Stam, F. C., Tilders, F. J. H., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000126778 · Cited by 667 · see citing works

Do early‐life events permanently alter behavioral and hormonal responses to stressors?

Anisman, H., Zaharia, M. D., Meaney, M. J., & Merali, Z. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00025-2 · Cited by 654 · see citing works

The lifetime prevalence of child sexual abuse and sexual assault assessed in late adolescence

Finkelhor, D., Shattuck, A., Turner, H. A., & Hamby, S. L. (2014) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2013.12.026 · Cited by 631 · see citing works

Neurobiological and psychiatric consequences of child abuse and neglect

Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B. (2010) · Developmental Psychobiology · doi:10.1002/dev.20494 · Cited by 613 · see citing works

The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?

Anacker, C., Zunszain, P. A., Carvalho, L. A., & Pariante, C. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.007 · Cited by 592 · see citing works

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome

Daskalakis, N. P., Bagot, R. C., Parker, K. J., Vinkers, C. H., & de Kloet, E. R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.008 · Cited by 579 · see citing works

Variations in maternal care in infancy regulate the development of stress reactivity

Caldji, C., Diorio, J. C., & Meaney, M. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01084-2 · Cited by 574 · see citing works

Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment

Carpenter, L. L., Carvalho, J. P., Tyrka, A. R., Wier, L. M., Mello, A. F., Mello, M. F., Anderson, G. M., Wilkinson, C. W., & Price, L. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.002 · Cited by 564 · see citing works

Measuring child maltreatment in the United Kingdom: A study of the prevalence of child abuse and neglect

May‐Chahal, C., & Cawson, P. (2005) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2004.05.009 · Cited by 531 · see citing works

Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma

Perroud, N., Paoloni-Giacobino, A., Prada, P., Olié, E., Salzmann, A., Nicastro, R., Guillaume, S., Mouthon, D., Stouder, C., Dieben, K., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.60 · Cited by 516 · see citing works

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health

Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513 · see citing works

Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor

Radtke, K. M., Ruf, M., Gunter, H. M., Dohrmann, K., Schauer, M., Meyer, A., & Elbert, T. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.21 · Cited by 511 · see citing works

Epigenetic mechanisms in cognition

Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510 · see citing works

The Transcription Factor Nerve Growth Factor-Inducible Protein A Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes

Weaver, I. C. G., D'Alessio, A. C., Brown, S. E., Hellstrom, I. C., Dymov, S., Sharma, S., Szyf, M., & Meaney, M. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4164-06.2007 · Cited by 508 · see citing works

The Prevalence of Confirmed Maltreatment Among US Children, 2004 to 2011

Wildeman, C., Emanuel, N., Leventhal, J. M., Putnam‐Hornstein, E., Waldfogel, J., & Lee, H. E. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2014.410 · Cited by 488 · see citing works

Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults

Tyrka, A. R., Price, L. H., Marsit, C., Walters, O. C., & Carpenter, L. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030148 · Cited by 486 · see citing works

Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology

Schmidt, H. D., Shelton, R. C., & Duman, R. S. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.151 · Cited by 477 · see citing works

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr416 · Cited by 460 · see citing works

DSM-5 and RDoC: progress in psychiatry research?

Casey, B. J., Craddock, N., Cuthbert, B. N., Hyman, S. E., Lee, F. S., & Ressler, K. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3621 · Cited by 434 · see citing works

Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders

Webster, M. J., Knable, M. B., O'Grady, J., Orthmann, J., & Weickert, C. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001139 · Cited by 420 · see citing works

Epigenetics of the depressed brain: role of histone acetylation and methylation

Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works

The prevalence and impact of child maltreatment and other types of victimization in the UK: Findings from a population survey of caregivers, children and young people and young adults

Radford, L., Corral, S., Bradley, C., & Fisher, H. L. (2013) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2013.02.004 · Cited by 413 · see citing works

Epigenetics across the human lifespan

Kanherkar, R. R., Bhatia-Dey, N., & Csoka, A. B. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00049 · Cited by 407 · see citing works

Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior

Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378 · see citing works

HPA axis and aging in depression: Systematic review and meta-analysis

Belvederi Murri, M., Pariante, C., Mondelli, V., Masotti, M., Atti, A. R., Mellacqua, Z., Antonioli, M., Ghio, L., Menchetti, M., Zanetidou, S., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.12.004 · Cited by 367 · see citing works

Diminished cortisol responses to psychosocial stress associated with lifetime adverse events

Elzinga, B. M., Roelofs, K., Tollenaar, M. S., Bakvis, P., van Pelt, J., & Spinhoven, P. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.11.004 · Cited by 364 · see citing works

Epigenetic programming of stress responses through variations in maternal care

FISH, E. W., SHAHROKH, D., BAGOT, R., CALDJI, C., BREDY, T., SZYF, M., & MEANEY, M. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1330.011 · Cited by 361 · see citing works

Differential Glucocorticoid Receptor Exon 1B, 1C, and 1H Expression and Methylation in Suicide Completers with a History of Childhood Abuse

Labonte, B., Yerko, V., Gross, J., Mechawar, N., Meaney, M. J., Szyf, M., & Turecki, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.034 · Cited by 345 · see citing works

Methylation changes at <i>NR3C1</i> in newborns associate with maternal prenatal stress exposure and newborn birth weight

Mulligan, C., D'Errico, N., Stees, J., & Hughes, D. (2012) · Epigenetics · doi:10.4161/epi.21180 · Cited by 342 · see citing works

Combined Dexamethasone/Corticotropin Releasing Hormone Test Predicts Treatment Response in Major Depression–A Potential Biomarker?

Ising, M., Horstmann, S., Kloiber, S., Lucae, S., Binder, E. B., Kern, N., Künzel, H. E., Pfennig, A., Uhr, M., & Holsboer, F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.039 · Cited by 341 · see citing works

Early Sexual Abuse and Clinical Depression in Adult Life

Bifulco, A., Brown, G. W., & Adler, Z. (1991) · British Journal of Psychiatry · doi:10.1192/bjp.159.1.115 · Cited by 335 · see citing works

Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus

Suderman, M., McGowan, P. O., Sasaki, A., Huang, T. C. T., Hallett, M. T., Meaney, M. J., Turecki, G., & Szyf, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121260109 · Cited by 327 · see citing works

Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits

Wong, C. C. Y., Meaburn, E. L., Ronald, A., Price, T. S., Jeffries, A. R., Schalkwyk, L. C., Plomin, R., & Mill, J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.41 · Cited by 327 · see citing works

Use of Epigenetic Drugs in Disease: An Overview

Heerboth, S., LAPINSKA, K., Snyder, N., Leary, M., Rollinson, S., & Sarkar, S. (2014) · Genetics & Epigenetics · doi:10.4137/geg.s12270 · Cited by 325 · see citing works

The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells

Provençal, N., Suderman, M. J., Guillemin, C., Massart, R., Ruggiero, A., Wang, D., Bennett, A. J., Pierre, P. J., Friedman, D. P., Côté, S. M., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1470-12.2012 · Cited by 312 · see citing works

The role of DNA methylation in stress-related psychiatric disorders

Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309 · see citing works

Experience-Dependent Epigenetic Modifications in the Central Nervous System

Sweatt, J. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.002 · Cited by 307 · see citing works

Cortisol and depression: three questions for psychiatry

Herbert, J. (2013) · Psychological Medicine · doi:10.1017/s0033291712000955 · Cited by 301 · see citing works

The roles of DNA methylation of NR3C1 and 11β-HSD2 and exposure to maternal mood disorder in utero on newborn neurobehavior

Conradt, E. D., Lester, B. M., Appleton, A. A., Armstrong, D. A., & Marsit, C. J. (2013) · Epigenetics · doi:10.4161/epi.26634 · Cited by 299 · see citing works

Induction of Epigenetic Alterations by Dietary and Other Environmental Factors

Mathers, J. C., Strathdee, G. R., & Relton, C. L. (2010) · Advances in genetics · doi:10.1016/b978-0-12-380864-6.00001-8 · Cited by 292 · see citing works

Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene (NR3C1) promoter region in cord blood

Hompes, T., Izzi, B., Gellens, E., Morreels, M., Fieuws, S., Pexsters, A., Schops, G., Dom, M., Van Bree, R., Freson, K., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.03.009 · Cited by 262 · see citing works

Structure of the glucocorticoid receptor (NR3C1) gene 5′ untranslated region: identification, and tissue distribution of multiple new human exon 1

Turner, J. D., & Muller, C. P. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01822 · Cited by 256 · see citing works

Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders

Yehuda, R., Boisoneau, D., Mason, J. W., & Giller, E. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90252-9 · Cited by 253 · see citing works

Childhood parental loss and adult hypothalamic-pituitary-adrenal function

Tyrka, A. R., Wier, L., Price, L. H., Ross, N., Anderson, G. M., Wilkinson, C. W., & Carpenter, L. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.011 · Cited by 250 · see citing works

Methylome-Wide Association Study of Schizophrenia: Identifying Blood Biomarker Signatures of Environmental Insults

Aberg, K. A., McClay, J. L., Nerella, S., Clark, S., Kumar, G., Chen, W., Khachane, A. N., Xie, L., Hudson, A., Gao, G., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3730 · Cited by 248 · see citing works

Enhancer Function: Mechanistic and Genome-Wide Insights Come Together

Plank, J. L., & Dean, A. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.015 · Cited by 246 · see citing works

On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”

Tylee, D. S., Kawaguchi, D. M., & Glatt, S. J. (2013) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32150 · Cited by 243 · see citing works

Genome-Wide Association Study of Major Recurrent Depression in the U.K. Population

Lewis, C. M., Ng, M., Butler, A. W., Cohen‐Woods, S., Uher, R., Pirlo, K. J., Weale, M. E., Schosser, A., Paredes, U. M., Rivera, M., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091380 · Cited by 237 · see citing works

Cortisol Secretion Rate in Depressive Illness

GIBBONS, J. L. (1964) · Archives of General Psychiatry · doi:10.1001/archpsyc.1964.01720240026004 · Cited by 229 · see citing works

Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities

Melas, P. A., Wei, Y., Wong, C. C. Y., Sjöholm, L. K., Åberg, E., Mill, J., Schalling, M., Forsell, Y., & Lavebratt, C. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000102 · Cited by 220 · see citing works

Epigenetics of posttraumatic stress disorder: current evidence, challenges, and future directions

Zannas, A. S., Provençal, N., & Binder, E. B. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.003 · Cited by 218 · see citing works

Analysis of whole genome biomarker expression in blood and brain

Rollins, B. L., Martin, M. V., Morgan, L. Z., & Vawter, M. P. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31062 · Cited by 217 · see citing works

Epigenetic Regulation in Human Brain—Focus on Histone Lysine Methylation

Akbarian, S., & Huang, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.015 · Cited by 214 · see citing works

Enduring psychobiological effects of childhood adversity

Ehlert, U. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.007 · Cited by 213 · see citing works

The size, burden and cost of disorders of the brain in the UK

Fineberg, N. A., Haddad, P. M., Carpenter, L., Gannon, B., Sharpe, R., Young, A. H., Joyce, E. M., Rowe, J. B., Wellsted, D. M., Nutt, D., et al. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113495118 · Cited by 213 · see citing works

Stability in symptoms of anxiety and depression as a function of genotype and environment: a longitudinal twin study from ages 3 to 63 years

Nivard, M. G., Dolan, C. V., Kendler, K. S., Kan, K.-J., Willemsen, G., van Beijsterveldt, C. E. M., Lindauer, R. J. L., van Beek, J. H. D. A., Geels, L. M., Bartels, M., et al. (2015) · Psychological Medicine · doi:10.1017/s003329171400213x · Cited by 213 · see citing works

The Predictive Capacity of Personal Genome Sequencing

Roberts, N. J., Vogelstein, J. T., Parmigiani, G., Kinzler, K. W., Vogelstein, B., & Velculescu, V. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003380 · Cited by 213 · see citing works

Epigenetics of discordant monozygotic twins: implications for disease

Fernandez, J. C., Spector, T. D., & Bell, J. T. (2014) · Genome Medicine · doi:10.1186/s13073-014-0060-z · Cited by 209 · see citing works

Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA‐mediated down‐regulation of the glucocorticoid receptor

Uchida, S., Nishida, A., Hara, K., Kamemoto, T., Suetsugi, M., Fujimoto, M., Watanuki, T., Wakabayashi, Y., Otsuki, K., McEwen, B. S., et al. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06218.x · Cited by 203 · see citing works

Epigenetics of Early Child Development

Murgatroyd, C., & Spengler, D. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00016 · Cited by 195 · see citing works

The glucocorticoid receptor: part of the solution or part of the problem?

Pariante, C. M. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066063 · Cited by 192 · see citing works

Not fade away: the HPA axis and depression

Cowen, P. J. (2010) · Psychological Medicine · doi:10.1017/s0033291709005558 · Cited by 191 · see citing works

Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed

Alt, S. R., Turner, J. D., Klok, M. D., Meijer, O. C., Lakke, E. A. J. F., DeRijk, R. H., & Muller, C. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.001 · Cited by 184 · see citing works

Risk Factors for Development of Depression and Psychosis

Pariante, C. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04978.x · Cited by 181 · see citing works

Epigenetic Inheritance of Disease and Disease Risk

Bohacek, J., & Mansuy, I. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.110 · Cited by 176 · see citing works

Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines

Ou, J.-N., Torrisani, J., Unterberger, A., Provençal, N., Shikimi, K., Karimi, M., Ekström, T. J., & Moshe Szyf, A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.12.032 · Cited by 172 · see citing works

Epigenetic signaling in psychiatric disorders: stress and depression

Bagot, R. C., Labonté, B., Peña, C. J., & Nestler, E. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/rbagot · Cited by 171 · see citing works

Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene

Murgatroyd, C., Quinn, J. P., Sharp, H. M., Pickles, A. R., & Hill, J. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.140 · Cited by 168 · see citing works

Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression

Massart, R., Mongeau, R., & Lanfumey, L. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0212 · Cited by 167 · see citing works

Mood and neuropsychological function in depression: the role of corticosteroids and serotonin

McAllister-Williams, H., Ferrier, I. N., & Young, A. H. (1998) · Psychological Medicine · doi:10.1017/s0033291798006680 · Cited by 165 · see citing works

Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?

Levinson, D. F., Mostafavi, S., Milaneschi, Y., Rivera, M., Ripke, S., Wray, N. R., & Sullivan, P. F. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.029 · Cited by 159 · see citing works

Serotonergic genes and suicide: A systematic review

Antypa, N., Serretti, A., & Rujescu, D. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.03.013 · Cited by 150 · see citing works

Childhood parental loss and cortisol levels in adult men

Nicolson, N. A. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.09.005 · Cited by 149 · see citing works

Making memories of stressful events: a journey along epigenetic, gene transcription, and signaling pathways

Reul, J. M. H. M. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00005 · Cited by 147 · see citing works

Resolving multiple epigenetic pathways to adolescent depression

Eaves, L. J., Silberg, J. L., & Erkanli, A. (2003) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00185 · Cited by 147 · see citing works

Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more

Turner, J. D., Alt, S. R., Cao, L., Vernocchi, S., Trifonova, S. T., Battello, N., & Muller, C. P. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.037 · Cited by 145 · see citing works

Association between Glucocorticoid Receptor Methylation and Hippocampal Subfields in Major Depressive Disorder

Na, K., Chang, H. S., Won, E., Han, K., Choi, S., Tae, W., Yoon, H., Kim, Y., Joe, S., Jung, I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085425 · Cited by 144 · see citing works

Frequency of Infant Stroking Reported by Mothers Moderates the Effect of Prenatal Depression on Infant Behavioural and Physiological Outcomes

Sharp, H. M., Pickles, A. R., Meaney, M. J., Marshall, K. H., Tibu, F., & Hill, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045446 · Cited by 140 · see citing works

Transgenerational Epigenetic Effects on Brain Functions

Bohacek, J., Gapp, K., Saab, B. J., & Mansuy, I. M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.019 · Cited by 137 · see citing works

Genome-wide Methylomic Analysis of Monozygotic Twins Discordant for Adolescent Depression

Dempster, E. L., Wong, C. C. Y., Lester, K. J., Burrage, J., Gregory, A. M., Mill, J. S., & Eley, T. C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.013 · Cited by 132 · see citing works

Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder

GALLAGHER, P., WATSON, S., SMITH, M., YOUNG, A., & FERRIER, I. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2006.11.020 · Cited by 129 · see citing works

Depression pathogenesis and treatment: what can we learn from blood mRNA expression?

Hepgul, N., Cattaneo, A., Zunszain, P. A., & Pariante, C. M. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-28 · Cited by 127 · see citing works

Nongenetic Transmission of Information

Denenberg, V. H., & Rosenberg, K. M. (1967) · Nature · doi:10.1038/216549a0 · Cited by 127 · see citing works

Childhood trauma and suicide risk in a sample of young individuals aged 14–35 years in southern Brazil

Barbosa, L. P., Quevedo, L. D. Á., da Silva, G. D. G., Jansen, K., Pinheiro, R. T., Branco, J. C., Lara, D. R., Oses, J. P., & da Silva, R. A. (2014) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2014.02.008 · Cited by 125 · see citing works

Statistical methods for detecting differentially methylated loci and regions

Robinson, M. D., Kahraman, A., Law, C. W., Lindsay, H. A., Nowicka, M., Weber, L. M., & Zhou, X. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00324 · Cited by 124 · see citing works

Quantifying Missing Heritability at Known GWAS Loci

Gusev, A., Bhatia, G., Zaitlen, N., Vilhjálmsson, B. J., Diogo, D., Stahl, E. A., Gregersen, P. K., Worthington, J., Klareskog, L., Raychaudhuri, S., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003993 · Cited by 123 · see citing works

Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder

Medina, A., Seasholtz, A. F., Sharma, V., Burke, S., Bunney, W. E., Myers, R., Schatzberg, A. F., Akil, H., & Watson, S. J. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.11.002 · Cited by 120 · see citing works

Maternal separation alters nerve growth factor and corticosterone levels but not the DNA methylation status of the exon 17 glucocorticoid receptor promoter region

Daniels, W. M. U., Fairbairn, L., van Tilburg, G., McEvoy, C. R. E., Zigmond, M. J., Russell, V. A., & Stein, D. J. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-009-9163-4 · Cited by 118 · see citing works

Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress–diathesis model of depression

Booij, L., Wang, D., Lévesque, M. L., Tremblay, R. E., & Moshe Szyf, A. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0251 · Cited by 114 · see citing works

Epigenetic epidemiology: Promises for public health research

Bakulski, K. M., & Fallin, M. D. (2014) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21850 · Cited by 112 · see citing works

Cortisol in Mood Disorders

Young, A. H. (2004) · Stress · doi:10.1080/10253890500069189 · Cited by 111 · see citing works

Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: Systematic review of contributing factors

Daskalakis, N. P., & Yehuda, R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00369 · Cited by 108 · see citing works

DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human.

Simar, D., Versteyhe, S., Donkin, I., Liu, J., Hesson, L., Nylander, V., Fossum, A., & Barrès, R. (2014) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2014.05.014 · Cited by 108 · see citing works

Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients

Wang, Q., Verweij, E. W. E., Krugers, H. J., Joëls, M., Swaab, D. F., & Lucassen, P. J. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0589-4 · Cited by 107 · see citing works

Antidepressant drug action in a transgenic mouse model of the endocrine changes seen in depression

Pepin, M. C., Pothier, F., & Barden, N. (1992) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09284-3 · Cited by 105 · see citing works

Glucocorticoid Sensitivity in Mood Disorders

Spijker, A. T., & van Rossum, E. F. C. (2011) · Neuroendocrinology · doi:10.1159/000329846 · Cited by 102 · see citing works

Effects of early life social stress on maternal behavior and neuroendocrinology

Murgatroyd, C., & Nephew, B. C. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.020 · Cited by 100 · see citing works

FKBP5 polymorphism is associated with major depression but not with bipolar disorder

Szczepankiewicz, A., Leszczyńska-Rodziewicz, A., Pawlak, J., Narozna, B., Rajewska-Rager, A., Wilkosc, M., Zaremba, D., Maciukiewicz, M., & Twarowska-Hauser, J. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.002 · Cited by 100 · see citing works

Biology, Genes, and Resilience

Bowes, L., & Jaffee, S. R. (2013) · Trauma Violence & Abuse · doi:10.1177/1524838013487807 · Cited by 99 · see citing works

Tissue specific glucocorticoid receptor expression, a role for alternative first exon usage?

Turner, J. D., Schote, A. B., Macedo, J. A., Pelascini, L. P. L., & Muller, C. P. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.005 · Cited by 99 · see citing works

Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment

Calfa, G. D., Kademian, S., Ceschin, D. G., Vega, G., Rabinovich, G. A., & Volosin, M. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00051-3 · Cited by 97 · see citing works

Glucocorticoid receptor polymorphisms and haplotypes and their expression in health and disease

Koper, J. W., van Rossum, E. F. C., & van den Akker, E. L. T. (2014) · Steroids · doi:10.1016/j.steroids.2014.07.015 · Cited by 97 · see citing works

Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and Depression

Hornung, O., & Heim, C. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00014 · Cited by 86 · see citing works

Gene–environment interactions in common mental disorders: an update and strategy for a genome-wide search

Uher, R. (2013) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-013-0801-0 · Cited by 83 · see citing works

The current state of play on the molecular genetics of depression

Cohen-Woods, S., Craig, I. W., & McGuffin, P. (2013) · Psychological Medicine · doi:10.1017/s0033291712001286 · Cited by 82 · see citing works

Hypothalamic-Pituitary-Adrenocortical Axis Changes in a Transgenic Mouse with Impaired Glucocorticoid Receptor Function

Karanth, S., Linthorst, A. C. E., Stalla, G. K., Barden, N., Holsboer, F., & Reul, J. M. H. M. (1997) · Endocrinology · doi:10.1210/endo.138.8.5331 · Cited by 79 · see citing works

The glucocorticoid receptor gene is in 5q–q32

Francke, U., & Foellmer, B. E. (1989) · Genomics · doi:10.1016/0888-7543(89)90287-5 · Cited by 77 · see citing works

Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum

Engineer, N., Darwin, L., Deole, N., Kandala, N., Smith, S. C., & Grammatopoulos, D. K. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.003 · Cited by 73 · see citing works

The DEX/CRH neuroendocrine test and the prediction of depressive relapse in remitted depressed outpatients

Aubry, J., Gervasoni, N., Osiek, C., Perret, G., Rossier, M. F., Bertschy, G., & Bondolfi, G. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.007 · Cited by 69 · see citing works

Epigenetic and genetic factors predict women’s salivary cortisol following a threat to the social self

Edelman, S., Shalev, I., Uzefovsky, F., Israel, S., Knafo, A., Kremer, I., Mankuta, D., Kaitz, M., & Ebstein, R. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048597 · Cited by 64 · see citing works

Volume of the adrenal and pituitary glands in depression

Kessing, L. V., Willer, I. S., & Knorr, U. B. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.05.007 · Cited by 63 · see citing works

A 35-Year Longitudinal Assessment of Cognition and Midlife Depression Symptoms: The Vietnam Era Twin Study of Aging

Franz, C. E., Lyons, M. J., O'Brien, R., Panizzon, M. S., Kim, K., Bhat, R., Grant, M. D., Toomey, R., Eisen, S., Xian, H., et al. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181ef79f1 · Cited by 62 · see citing works

Revisiting telegony: offspring inherit an acquired characteristic of their mother's previous mate

Crean, A. J., Kopps, A. M., & Russell Bonduriansky, A. (2014) · Ecology Letters · doi:10.1111/ele.12373 · Cited by 62 · see citing works

The effect of chronic fluoxetine treatment on brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats

Yau, J. L. W., Hibberd, C. J., Noble, J., & Seckl, J. R. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00418-7 · Cited by 56 · see citing works

Epigenetic Modulation of Mood Disorders

Archer, T. (2013) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000120 · Cited by 51 · see citing works

The glucocorticoid receptor gene exon 1-F promoter is not methylated at the NGFI-A binding site in human hippocampus

Moser, D., Molitor, A. M., Kumsta, R., Tatschner, T., Riederer, P. F., & Meyer, J. (2007) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701429862 · Cited by 50 · see citing works

Social stress during lactation, depressed maternal care, and neuropeptidergic gene expression

Murgatroyd, C., Taliefar, M., Bradburn, S., Carini, L. M., Babb, J. A., & Nephew, B. C. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000147 · Cited by 50 · see citing works

Single nucleotide polymorphisms of NR3C1 gene and recurrent depressive disorder in population of Poland

Gałecka, E., Szemraj, J., Bieńkiewicz, M., Majsterek, I., Przybyłowska-Sygut, K., Gałecki, P., & Lewiñski, A. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2220-9 · Cited by 47 · see citing works

FUNCTIONAL POLYMORPHISM IN THE BRAIN-DERIVED NEUROTROPHIC FACTOR GENE INTERACTS WITH STRESSFUL LIFE EVENTS BUT NOT CHILDHOOD MALTREATMENT IN THE ETIOLOGY OF DEPRESSION

Brown, G. W., Craig, T., Harris, T., Herbert, J., Hodgson, K., Tansey, K. E., & Uher, R. (2013) · Depression and Anxiety · doi:10.1002/da.22221 · Cited by 44 · see citing works

Homing in on Depression Genes

McGuffin, P., Cohen‐Woods, S., & Knight, J. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.2.195 · Cited by 44 · see citing works

Family history, early adversity and the hypothalamic-pituitary-adrenal (HPA) axis: Mediation of the vulnerability to mood disorders

Watson, S., Owen, B. M., Gallagher, P., Hearn, A. J., Young, A. H., & Ferrier, I. N. (2007) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a939 · Cited by 42 · see citing works

Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals

Glossop, J. R., Nixon, N. B., Emes, R. D., Haworth, K. E., Packham, J., Dawes, P. T., Fryer, A. A., Mattey, D. L., & Farrell, W. E. (2013) · Epigenetics · doi:10.4161/epi.26265 · Cited by 42 · see citing works

Pituitary-adrenal cortical axis measures as predictors of sustained remission in major depression

O’Toole, S. M., Sekula, L. K., & Rubín, R. T. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00293-4 · Cited by 40 · see citing works

Differential Regulation and Function of 5′-Untranslated GR-Exon 1 Transcripts

Bockmühl, Y., Murgatroyd, C., Kuczynska, A., Adcock, I. M., Almeida, O. F. X., & Spengler, D. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0436 · Cited by 39 · see citing works

Role of the 5′-untranslated regions in post-transcriptional regulation of the human glucocorticoid receptor

Turner, J. D., Vernocchi, S., Schmitz, S., & Muller, C. P. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.08.010 · Cited by 38 · see citing works

No Associations Between Single Nucleotide Polymorphisms in Corticoid Receptor Genes and Heart Rate and Cortisol Responses to a Standardized Social Stress Test in Adolescents: The TRAILS Study

Bouma, E., Riese, H., Nolte, I. M., Oosterom, E., Verhulst, F. C., Ormel, J., & Oldehinkel, A. J. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9385-6 · Cited by 33 · see citing works

Genetic Variants in the Genes of the Stress Hormone Signalling Pathway and Depressive Symptoms during and after Pregnancy

Schneider, M. O., Engel, A., Fasching, P. A., Häberle, L., Binder, E. B., Voigt, F., Grimm, J., Faschingbauer, F., Eichler, A., Dammer, U., et al. (2014) · BioMed Research International · doi:10.1155/2014/469278 · Cited by 29 · see citing works

Epigenetic modifications associated with suicide and common mood and anxiety disorders: a systematic review of the literature

El‐Sayed, A. M., Haloossim, M., Galea, S., & Koenen, K. C. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-10 · Cited by 29 · see citing works

Dysregulation of the Epigenome in Human Breast Cancer

Sandhu, R., Roll, J. D., Rivenbark, A. G., & Coleman, W. B. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.12.003 · Cited by 25 · see citing works

Epigenomics starts to make its mark

Callaway, E. (2014) · Nature · doi:10.1038/508022a · Cited by 25 · see citing works

Genome‐wide polygenic scoring for a 14‐year long‐term average depression phenotype

Chang, S., Glymour, M. M., Walter, S., Liang, L., Koenen, K. C., Tchetgen, E. J. T., Cornelis, M. C., Kawachi, I. I., Rimm, E. B., & Kubzansky, L. D. (2014) · Brain and Behavior · doi:10.1002/brb3.205 · Cited by 22 · see citing works

A recessive genetic model and runs of homozygosity in major depressive disorder

Power, R. A., Keller, M. C., Ripke, S., Abdellaoui, A., Wray, N. R., Sullivan, P. F., MDD PGC Working Group, & Breen, G. D. (2014) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32217 · Cited by 22 · see citing works

Population transcriptomics with single‐cell resolution: A new field made possible by microfluidics

Plessy, C., Simon-Desbois, L., Fujii, T., & Carninci, P. (2012) · BioEssays · doi:10.1002/bies.201200093 · Cited by 21 · see citing works

Glucocorticoid receptor gene haplotype predicts increased risk of hospital admission for depressive disorders in the Helsinki birth cohort study

Lahti, J. M. T., Räikkönen, K., Bruce, S., Heinonen, K., Pesonen, A., Rautanen, A., Wahlbeck, K., Kere, J., Kajantie, E., & Eriksson, J. G. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.008 · Cited by 17 · see citing works

Maternal Depression and Child and Adolescent Depression Symptoms: An Exploratory Test for Moderation by CRHR1, FKBP5 and NR3C1 Gene Variants

Lewis, G., Collishaw, S., Harold, G. T., Rice, F. J., & Thapar, A. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9482-1 · Cited by 14 · see citing works

Child maltreatment in Puerto Rico: findings from the 2010 National Child Abuse and Neglect Data System.

Ishida, K., Klevens, J., Rivera-García, B., & Mirabal, B. (2013) · PubMed · Cited by 11 · see citing works

Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia

Sulistyoningrum, D. C., Singh, R., & Devlin, A. M. (2012) · Epigenetics · doi:10.4161/epi.19836 · Cited by 10 · see citing works

Encode and a new landscape for psychiatric genetics

Nair, A., & Howard, R. J. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.127191 · Cited by 6 · see citing works

Journal retracts article that said childhood trauma could lead to genetic changes

Dyer, O. (2014) · BMJ · doi:10.1136/bmj.g5543 · Cited by 1 · see citing works

What is mood? A computational perspective

Clark, J. E., Watson, S., & Friston, K. J. (2018) · Psychological Medicine · doi:10.1017/s0033291718000430 · Cited by 204 · see citing works

DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse

Farrell, C., Doolin, K., O’ Leary, N., Jairaj, C., Roddy, D., Tozzi, L., Morris, D., Harkin, A., Frodl, T., Nemoda, Z., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.064 · Cited by 144 · see citing works

Childhood trauma, DNA methylation of stress-related genes, and depression: findings from two monozygotic twin studies

Peng, H., Zhu, Y., Strachan, E., Fowler, E., Bacus, T., Roy-Byrne, P., Goldberg, J., Vaccarino, V., & Zhao, J. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000604 · Cited by 99 · see citing works

An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders

Kuan, P.-F., Waszczuk, M. A., Kotov, R., Marsit, C. J., Guffanti, G., Gonzalez, A., Yang, X., Koenen, K., Bromet, E., & Luft, B. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.130 · Cited by 103 · see citing works

Epigenetic programming by early-life stress

Alyamani, R. A. S., & Murgatroyd, C. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2018.01.004 · Cited by 76 · see citing works

Biological alterations affecting risk of adult psychopathology following childhood trauma: a review of sex differences

Tiwari, A., & Gonzalez, A. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.01.006 · Cited by 71 · see citing works

Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases.

Shchaslyvyi, A. Y., Antonenko, S. V., & Telegeev, G. D. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081077 · Cited by 73 · see citing works

Stress impairs response to antidepressants via HPA axis and immune system activation

Menke, A., Nitschke, F., Hellmuth, A., Helmel, J., Wurst, C., Stonawski, S., Blickle, M., Weiß, C., Weber, H., Hommers, L., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.12.033 · Cited by 40 · see citing works

Maternal care, the epigenome and phenotypic differences in behavior

Moshe Szyf, A., Weaver, I. C. G., & Meaney, M. J. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.001 · Cited by 263 · see citing works

The Ability of Nutrition to Mitigate Epigenetic Drift: A Novel Look at Regulating Gene Expression

Palmer, R. D., Papa, V., & Vaccarezza, M. (2021) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.67.359 · Cited by 2 · see citing works

Nutrition, epigenetics and health through life

Malcomson, F. C., & Mathers, J. C. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12281 · Cited by 13 · see citing works

Nutrition and the Epigenome

Haggarty, P. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398397-8.00016-2 · Cited by 31 · see citing works

Cause and effect in epigenetics – where lies the truth, and how can experiments reveal it?

Klutstein, M. (2020) · BioEssays · doi:10.1002/bies.202000262 · Cited by 4 · see citing works