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Cited by 205

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial

Open access
Tresserra-Rimbau, Anna, Rimm, Eric B, Medina-Remón, Alexander, Martínez-González, Miguel A, López-Sabater, M Carmen, Covas, María I, Corella, Dolores, Salas-Salvadó, Jordi, Gómez-Gracia, Enrique, Lapetra, José, Arós, Fernando, Fiol, Miquel, Ros, Emili, Serra-Majem, Lluis, Pintó, Xavier, Muñoz, Miguel A, Gea, Alfredo, Ruiz-Gutiérrez, Valentina, Estruch, Ramón, Lamuela-Raventós, Rosa M·2014·BMC Medicine
DOI 10.1186/1741-7015-12-77
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Abstract

BACKGROUND: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk. METHODS: We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter, controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated using time-dependent Cox proportional hazard models. RESULTS: Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses, stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent in the rest (flavonoids or phenolic acids). CONCLUSIONS: Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause mortality. CLINICAL TRIAL REGISTRATION: ISRCTN35739639.

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Research works printed but not linked: 31

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Metadata

Authors
Tresserra-Rimbau, A., Rimm, E. B., Medina-Remón, A., Martínez-González, M. A., López-Sabater, M. C., Covas, M. I., Corella, D., Salas-Salvadó, J., Gómez-Gracia, E., Lapetra, J., Arós, F., Fiol, M., Ros, E., Serra-Majem, L., Pintó, X., Muñoz, M. A., Gea, A., Ruiz-Gutiérrez, V., Estruch, R., & Lamuela-Raventós, R. M.
Venue
BMC Medicine
Publisher
Springer Science and Business Media LLC
Published
2014-05-13
Volume
12
Issue
1
Pages
77-77
ISSN
1741-7015 (ISSN-L)
DOI
10.1186/1741-7015-12-77
OpenAlex
W2104082616
Cited by
205
References
11
FWCI
19.00
Type
journal article
Language
en
Open access
gold
Licence

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CoChat. (2026). Citation check: Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial. https://app.cochat.ai/papers/10.1186/1741-7015-12-77
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Tresserra-Rimbau, A., Rimm, E. B., Medina-Remón, A., Martínez-González, M. A., López-Sabater, M. C., Covas, M. I., Corella, D., Salas-Salvadó, J., Gómez-Gracia, E., Lapetra, J., Arós, F., Fiol, M., Ros, E., Serra-Majem, L., Pintó, X., Muñoz, M. A., Gea, A., Ruiz-Gutiérrez, V., Estruch, R., & Lamuela-Raventós, R. M. (2014). Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial. BMC Medicine. https://doi.org/10.1186/1741-7015-12-77

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