The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
HIV-1 nef suppression by virally encoded microRNA
Open accessAbstract
Background: MicroRNAs (miRNAs) are 21~25-nucleotides (nt) long and interact with mRNAs to trigger either translational repression or RNA cleavage through RNA interference (RNAi), depending on the degree of complementarity with the target mRNAs. Our recent study has shown that HIV-1 nef dsRNA from AIDS patients who are long-term non-progressors (LTNPs) inhibited the transcription of HIV-1. Results: Here, we show the possibility that nef-derived miRNAs are produced in HIV-1 persistently infected cells. Furthermore, nef short hairpin RNA (shRNA) that corresponded to a predicted nef miRNA (~25 nt, miR-N367) can block HIV-1 Nef expression in vitro and the suppression by shRNA/miR-N367 would be related with low viremia in an LTNP (15-2-2). In the 15-2-2 model mice, the weight loss, which may be rendered by nef was also inhibited by shRNA/miR-N367 corresponding to suppression of nef expression in vivo. Conclusions: These data suggest that nef/U3 miRNAs produced in HIV-1-infected cells may suppress both Nef function and HIV-1 virulence through the RNAi pathway.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
Fragile X-related protein and VIG associate with the RNA interference machinery
Caudy, A. A., Myers, M., Hannon, G. J., & Hammond, S. M. (2002) · Genes & Development · doi:10.1101/gad.1025202 · Cited by 655
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
Ishizuka, A., Siomi, M. C., & Siomi, H. (2002) · Genes & Development · doi:10.1101/gad.1022002 · Cited by 581
Cited by
Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA
Narayanan, A., Iordanskiy, S., Das, R., Van Duyne, R., Santos, S., Jaworski, E., Guendel, I., Sampey, G., Dalby, E., Iglesias-Ussel, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438895 · Cited by 316
Yeung, M. L., Bennasser, Y., Watashi, K., Le, S.-Y., Houzet, L., & Jeang, K.-T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp707 · Cited by 244
Role of microRNAs in HTLV-1 infection and transformation
Ruggero, K., Corradin, A., Zanovello, P., Amadori, A., Bronte, V., Ciminale, V., & D’Agostino, D. M. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.05.001 · Cited by 41
Exploiting the Therapeutic Potential of MicroRNAs in Viral Diseases: Expectations and Limitations
Hemida, M. G., Ye, X., Thair, S., & Yang, D. (2010) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256383 · Cited by 32
van der Velden, Y. U., Kleibeuker, W., Harwig, A., Klaver, B., Siteur-van Rijnstra, E., Frankin, E., Berkhout, B., & Das, A. T. (2016) · Virology · doi:10.1016/j.virol.2015.11.004 · Cited by 3
Metadata
- Authors
- Omoto, S., Ito, M., Tsutsumi, Y., Ichikawa, Y., Okuyama, H., Brisibe, E. A., Saksena, N. K., & Fujii, Y. R.
- Venue
- Retrovirology
- Published
- 2004-12-15
- Volume
- 1
- Issue
- 1
- Pages
- 44-44
- ISSN
- 1742-4690 (ISSN-L)
- OpenAlex
- W1593416572
- Cited by
- 255
- References
- 4
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Omoto, S., Ito, M., Tsutsumi, Y., Ichikawa, Y., Okuyama, H., Brisibe, E. A., Saksena, N. K., & Fujii, Y. R. (2004). HIV-1 nef suppression by virally encoded microRNA. Retrovirology. https://doi.org/10.1186/1742-4690-1-44
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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