The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Does weight loss improve semen quality and reproductive hormones? results from a cohort of severely obese men
Open accessAbstract
BACKGROUND: A high body mass index (BMI) has been associated with reduced semen quality and male subfecundity, but no studies following obese men losing weight have yet been published. We examined semen quality and reproductive hormones among morbidly obese men and studied if weight loss improved the reproductive indicators. METHODS: In this pilot cohort study, 43 men with BMI > 33 kg/m² were followed through a 14 week residential weight loss program. The participants provided semen samples and had blood samples drawn, filled in questionnaires, and had clinical examinations before and after the intervention. Conventional semen characteristics as well as sperm DNA integrity, analysed by the sperm chromatin structure assay (SCSA) were obtained. Serum levels of testosterone, estradiol, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH) and inhibin B (Inh-B) were measured. RESULTS: Participants were from 20 to 59 years of age (median = 32) with BMI ranging from 33 to 61 kg/m². At baseline, after adjustment for potential confounders, BMI was inversely associated with sperm concentration (p = 0.02), total sperm count (p = 0.02), sperm morphology (p = 0.04), and motile sperm (p = 0.005) as well as testosterone (p = 0.04) and Inh-B (p = 0.04) and positively associated to estradiol (p < 0.005). The median (range) percentage weight loss after the intervention was 15% (3.5-25.4). Weight loss was associated with an increase in total sperm count (p = 0.02), semen volume (p = 0.04), testosterone (p = 0.02), SHBG (p = 0.03) and AMH (p = 0.02). The group with the largest weight loss had a statistically significant increase in total sperm count [193 millions (95% CI: 45; 341)] and normal sperm morphology [4% (95% CI: 1; 7)]. CONCLUSION: This study found obesity to be associated with poor semen quality and altered reproductive hormonal profile. Weight loss may potentially lead to improvement in semen quality. Whether the improvement is a result of the reduction in body weight per se or improved lifestyles remains unknown.
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Cites
EVENSON, D. P., LARSON, K. L., & JOST, L. K. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02599.x · Cited by 1,072 · cited 1×
“The details of this analysis have previously been described in detail [46,47].”
MethodThe evaluation of morphological characteristics of human spermatozoa according to stricter criteria
Menkveld, R., Stander, F. S. H., Kotze, T. J. V., Kruger, T. F., & Zyl, J. A. V. (1990) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137150 · Cited by 677
Obesity and androgens: facts and perspectives
Pasquali, R. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.054 · Cited by 469
Niskanen, L., Laaksonen, D. E., Punnonen, K., Mustajoki, P., Kaukua, J., & Rissanen, A. (2004) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00335.x · Cited by 275
The Effect of Weight Loss on Reproductive Hormones in Obese Men*
STANIK, S., DORNFELD, L. P., MAXWELL, M. H., VIOSCA, S. P., & KORENMAN, S. G. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-4-828 · Cited by 156
Effect of Massive Weight Loss on Hypothalamic Pituitary-Gonadal Function in Obese Men*
STRAIN, G. W., ZUMOFF, B., MILLER, L. K., ROSNER, W., LEVIT, C., KALIN, M., HERSHCOPF, R. J., & ROSENFELD, R. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-5-1019 · Cited by 103
Cited by
Impact of obesity on male fertility, sperm function and molecular composition
Palmer, N. O., Bakos, H. W., Fullston, T., & Lane, M. (2012) · Spermatogenesis · doi:10.4161/spmg.21362 · Cited by 403
Campbell, J. M., Lane, M., Owens, J. A., & Bakos, H. W. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.07.012 · Cited by 332
The relationship between male BMI and waist circumference on semen quality: data from the LIFE study
Eisenberg, M. L., Kim, S., Chen, Z., Sundaram, R., Schisterman, E. F., & Buck Louis, G. M. (2014) · Human Reproduction · doi:10.1093/humrep/det428 · Cited by 339
Obesity and male infertility: Mechanisms and management
Leisegang, K., Sengupta, P., Agarwal, A., & Henkel, R. (2021) · Andrologia · doi:10.1111/and.13617 · Cited by 308
European Academy of Andrology guideline Management of oligo‐astheno‐teratozoospermia
Colpi, G. M., Francavilla, S., Haidl, G., Link, K., Behre, H. M., Goulis, D. G., Krausz, C., & Giwercman, A. (2018) · Andrology · doi:10.1111/andr.12502 · Cited by 267
Metadata
- Authors
- Håkonsen, L. B., Thulstrup, A. M., Aggerholm, A. S., Olsen, J., Bonde, J. P., Andersen, C. Y., Bungum, M., Ernst, E. H., Hansen, M. L., Ernst, E. H., & Ramlau-Hansen, C. H.
- Venue
- Reproductive Health
- Published
- 2011-08-17
- Volume
- 8
- Issue
- 1
- Pages
- 24-24
- ISSN
- 1742-4755 (ISSN-L)
- OpenAlex
- W2128338905
- Cited by
- 332
- References
- 6
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Håkonsen, L. B., Thulstrup, A. M., Aggerholm, A. S., Olsen, J., Bonde, J. P., Andersen, C. Y., Bungum, M., Ernst, E. H., Hansen, M. L., Ernst, E. H., & Ramlau-Hansen, C. H. (2011). Does weight loss improve semen quality and reproductive hormones? results from a cohort of severely obese men. Reproductive Health. https://doi.org/10.1186/1742-4755-8-24
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