The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Obesity and male infertility: Mechanisms and management
Abstract
Obesity is considered a global health problem affecting more than a third of the population. Complications of obesity include cardiovascular diseases, type 2 diabetes mellitus, malignancy (including prostatic cancer), neurodegeneration and accelerated ageing. In males, these further include erectile dysfunction, poor semen quality and subclinical prostatitis. Although poorly understood, important mediators of obesity that may influence the male reproductive system include hyperinsulinemia, hyperleptinemia, chronic inflammation and oxidative stress. Obesity is known to disrupt male fertility and the reproduction potential, particularly through alteration in the hypothalamic-pituitary-gonadal axis, disruption of testicular steroidogenesis and metabolic dysregulation, including insulin, cytokines and adipokines. Importantly, obesity and its underlying mediators result in a negative impact on semen parameters, including sperm concentration, motility, viability and normal morphology. Moreover, obesity inhibits chromatin condensation, DNA fragmentation, increases apoptosis and epigenetic changes that can be transferred to the offspring. This review discusses the impact of obesity on the male reproductive system and fertility, including associated mechanisms. Furthermore, weight management strategies, lifestyle changes, prescription medication, and complementary and alternative medicine in the management of obesity-induced subfertility is discussed.
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Cited by
The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis
Boitrelle, F., Shah, R., Saleh, R., Henkel, R., Kandil, H., Chung, E., Vogiatzi, P., Zini, A., Arafa, M., & Agarwal, A. (2021) · Life · doi:10.3390/life11121368 · Cited by 271
“Due to the production of excessive amounts of ROS in numerous medical conditions, including varicocele [43], leukocytospermia [44], diabetes mellitus [45], and obesity [46], seminal OS develops.”
BackgroundSelf-citationChen, Y.-K., Liu, T.-T., Teia, F. K. F., & Xie, M.-Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1218880 · Cited by 74
Falvo, S., Minucci, S., Santillo, A., Senese, R., Chieffi Baccari, G., & Venditti, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1274035 · Cited by 30
Metadata
- Authors
- Leisegang, K., Sengupta, P., Agarwal, A., & Henkel, R.
- Venue
- Andrologia
- Publisher
- Wiley
- Published
- 2020-05-12
- Volume
- 53
- Issue
- 1
- Pages
- e13617-e13617
- ISSN
- 0303-4569 (ISSN-L)
- 1439-0272
- OpenAlex
- W3025509556
- Cited by
- 308
- References
- 117
- FWCI
- 26.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Leisegang, K., Sengupta, P., Agarwal, A., & Henkel, R. (2021). Obesity and male infertility: Mechanisms and management. Andrologia. https://doi.org/10.1111/and.13617
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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