The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility

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Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex

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The Importance of Gender-Related Anticancer Research on Mitochondrial Regulator Sodium Dichloroacetate in Preclinical Studies In Vivo

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Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki)

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Anti-Metastatic Effect of Pyruvate Dehydrogenase Kinase 4 Inhibition in Bladder Cancer via the ERK, SRC, and JNK Pathways

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Co-expression network analysis predicts a key role of microRNAs in the adaptation of the porcine skeletal muscle to nutrient supply

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Randomized Trial: D-Glyceric Acid Activates Mitochondrial Metabolism in 50–60-Year-Old Healthy Humans

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Tumor Cytokine-Induced Hepatic Gluconeogenesis Contributes to Cancer Cachexia: Insights from Full Body Single Nuclei SequencingPreprint

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Logical modelling reveals the PDC-PDK interaction as the regulatory switch driving metabolic flexibility at the cellular level

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Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery

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Potentiation of Lipotoxicity in Human EndoC‐βH1 β‐Cells by Glucose is Dependent on the Structure of Free Fatty Acids

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Condensin II protein dysfunction impacts mitochondrial respiration and stress response

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Age-related sarcopenia and the gut microbiome: mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions

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Interaction between Butyrate and Tumor Necrosis Factor α in Primary Rat Colonocytes

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Effects of UBE3A on Cell and Liver Metabolism through the Ubiquitination of PDHA1 and ACAT1

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Perfluorooctanoic acid-induced metabolic disorder via enhancing metabolism of glutamine and fatty acids in human intestinal cells

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Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock

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Dietary Complex and Slow Digestive Carbohydrates Prevent Fat Deposits During Catch-Up Growth in Rats

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Should nutrition therapy be modified to account for mitochondrial dysfunction in critical illness?

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Integrated proteome and phosphoproteome analysis of interscapular brown adipose and subcutaneous white adipose tissues upon high fat diet feeding in mouse

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Kinetic and data-driven modeling of pancreatic β-cell central carbon metabolism and insulin secretion

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Metabolomic changes associated with chronic arsenic exposure in a Bangladeshi population

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Long Non-coding RNAs Involved in Metabolic Alterations in Breast and Prostate Cancers

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Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and senescencePreprint

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Chlamydia Infection Remodels Host Cell Mitochondria to Alter Energy Metabolism and Subvert Apoptosis

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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity

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Characterizing 24-Hour Skeletal Muscle Gene Expression Alongside Metabolic and Endocrine Responses Under Diurnal Conditions

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microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism

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Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia

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Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells

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codY and pdhA Expression Is Induced in Staphylococcus epidermidis Biofilm and Planktonic Populations With Higher Proportions of Viable but Non-Culturable Cells

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Identification and subsequent validation of transcriptomic signature associated with metabolic status in endometrial cancer

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Whole Blood Gene Expression Profiling in Preclinical and Clinical Cattle Infected with Atypical Bovine Spongiform Encephalopathy

Xerxa, E., Barbisin, M., Chieppa, M. N., Krmac, H., Costassa, E. V., Vatta, P., Simmons, M. M., Caramelli, M., Casalone, C., Corona, C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153425 · Cited by 11

The scale-free nature of protein sequence space

Buchholz, P. C. F., Zeil, C., & Pleiss, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200815 · Cited by 13

A Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects Offspring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteins

Salto, R., Manzano, M., Girón, M. D., Cano, A., Castro, A., Vílchez, J. D., Cabrera, E., & López-Pedrosa, J. M. (2019) · Nutrients · doi:10.3390/nu11040844 · Cited by 12

A pH-Dependent Kinetic Model of Dihydrolipoamide Dehydrogenase from Multiple Organisms

Moxley, M. A., Beard, D. A., & Bazil, J. N. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.09.025 · Cited by 11

Targeting PDK4 to mitigate osimertinib-induced cardiotoxicity: Insights into mitochondria-endoplasmic reticulum crosstalk and necroptosis

Deng, J., Wang, D., Jiang, K., Lang, X., Sun, Y., & Li, Y. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.08.017 · Cited by 11

High-fat high-fructose diet and alpha-ketoglutarate affect mouse behavior that is accompanied by changes in oxidative stress response and energy metabolism in the cerebral cortex

Demianchuk, O., Vatashchuk, M., Gospodaryov, D. V., Hurza, V., Ivanochko, M. V., Derkachov, V., Berezovskyi, V., Lushchak, O. V., Storey, K. B., Bayliak, M. M., et al. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130521 · Cited by 10

Thyroid hormone increases fatty acid use in fetal ovine cardiac myocytes

Chattergoon, N. N., Louey, S., Jonker, S. S., & Thornburg, K. L. R. (2023) · Physiological Reports · doi:10.14814/phy2.15865 · Cited by 10

Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation

Griepke, S., Grentzmann, A., Tripodi, G. L., Hansen, J., da Fonseca, M. P., Nilsson, M. D., Tallouzi, Y., Grupe, E., Jensen, P. S., Beck, H. C., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf032 · Cited by 11

Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle

Park, J. M., Josan, S., Hurd, R. E., Graham, J. L., Havel, P. J., Bendahan, D., Mayer, D., Chung, Y., Spielman, D. M., & Jue, T. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02613-3 · Cited by 10

Glucocorticoid Receptor β Overexpression Has Agonist-Independent Insulin-Mimetic Effects on HepG2 Glucose Metabolism

Sepúlveda-Quiñenao, C., Rodriguez, J. M., Díaz‐Castro, F., del Campo, A., Bravo, R., & Troncoso, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105582 · Cited by 10

Lack of vitamin D signalling shifts skeletal muscles towards oxidative metabolism

Das, A., Jawla, N., Meena, V., Gopinath, S. D., & Arimbasseri, G. A. (2023) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13378 · Cited by 10

Hemorrhagic shock-induced cerebral bioenergetic imbalance is corrected by pharmacologic treatment with EF24 in a rat model

Rao, G., Xie, J., Hedrick, A. F., & Awasthi, V. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.033 · Cited by 10

The physiological and molecular response of Aurelia sp.1 under hypoxia

Wang, G., Zhen, Y., Yu, Z., Shi, Y., Zhao, Q., Wang, J., & Mi, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-01318-x · Cited by 10

Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose

Fuller, S. E., Yu, Y., Allerton, T. D., Mendoza, T. M., Ribnicky, D., & Floyd, Z. E. (2020) · Nutrients · doi:10.3390/nu12082233 · Cited by 9

The Effect of High-intensity Interval Training and L-carnitine on the Expression of Genes Involved in Lipid and Glucose Metabolism in the Liver of Wistar Rats

Shahouzehi, B., Masoumi‐Ardakani, Y., Nazari‐Robati, M., & Aminizadeh, S. (2022) · Brazilian Archives of Biology and Technology · doi:10.1590/1678-4324-2023220100 · Cited by 12

Changes in insulin, glucagon and ER stress precede immune activation in type 1 diabetes

Crookshank, J. A., Serrano, D., Wang, G., Patrick, C., Morgan, B., Paré, M., & Scott, F. W. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0328 · Cited by 9

Postnatal induction of muscle fatty acid oxidation in mice differing in propensity to obesity: a role of pyruvate dehydrogenase

Buresova, J., Janovská, P., Kuda, O., Křížová, J., van der Stelt, I., Keijer, J., Hansíková, H., Rossmeisl, M., & Kopecký, J. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0281-0 · Cited by 9

Transgenerational supplementation with eicosapentaenoic acid reduced the metabolic consequences on the whole body and skeletal muscle in mice receiving an obesogenic diet

Pinel, A., Rigaudière, J., Jouve, C., Montaurier, C., Jousse, C., Lhomme, M., Morio, B., & Capel, F. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02502-6 · Cited by 9

Insights into the Regulation of Spring Migration in Songbirds

Rani, S., Singh, S., Malik, S., & Kumar, V. (2017) · Springer eBooks · doi:10.1007/978-81-322-3688-7_30 · Cited by 9

Inhibition of PPARα target genes during cyclosporine A-induced nephrotoxicity and hepatotoxicity

Lee, E. H., Kim, S., Choi, M., Park, S., Moon, K., Yoon, S., & Oh, J. (2019) · Molecular & Cellular Toxicology · doi:10.1007/s13273-019-0022-z · Cited by 9

A new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutations

Bravo, N. B., Деордиева, Е. А., Doll, L., ElGamacy, M., Dannenmann, B., Azevedo, J., Iannuzzo, A., Delafontaine, S., Lehners, M., Kolodziej, M., et al. (2024) · Blood · doi:10.1182/blood.2023022576 · Cited by 9

Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration

Yu, F., Cong, S., Yap, E. P., Hausenloy, D. J., & Ramachandra, C. J. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210300 · Cited by 8

O304 ameliorates hyperglycemia in mice by dually promoting muscle glucose effectiveness and preserving β-cell function

Norlin, S., Axelsson, J., Ericsson, M., & Edlund, H. (2023) · Communications Biology · doi:10.1038/s42003-023-05255-6 · Cited by 9

Energy metabolism and redox balance: How phytochemicals influence heart failure treatment

Chen, C., Wang, J., Zhu, X., Hu, J., Liu, C., & Liu, L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116136 · Cited by 9

Regulation of the α-ketoglutarate dehydrogenasecomplex during hibernation in a small mammal, the Richardson's ground squirrel (Urocitellus richardsonii)

Green, S. R., & Storey, K. B. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140448 · Cited by 10

Untargeted metabolomics analysis on Cicer arietinium L.-Induced Amelioration in T2D rats by UPLC-Q-TOF-MS/MS

Lin, L., Zhang, S., Lin, Y., Liu, W., Zou, B., Cai, Y., Liu, D., Sun, Y., Zhong, Y., Xiao, D., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113013 · Cited by 8

Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes

Wang, X., Lai, S., Ye, Y., Hu, Y., Pan, D.-Y., Bai, X., & Shen, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.10993 · Cited by 8

Fasting and fasting mimetic supplementation address sirtuin expression, miRNA and microbiota composition

Lilja, S., Bäck, H., Duszka, K., Hippe, B., Suarez, L., Höfinger, I., Debebe, T., König, J. S., & Haslberger, A. G. (2020) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v10i10.752 · Cited by 8

Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases

Jeon, J., Thoudam, T., Choi, E. J., Kim, M., Harris, R. A., & Lee, I. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13345 · Cited by 67

PDK2: An Underappreciated Regulator of Liver Metabolism

Woolbright, B. L., & Harris, R. A. (2021) · Livers · doi:10.3390/livers1020008 · Cited by 4

Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs

Sugden, M. C., & Holness, M. J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00526.2002 · Cited by 428

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers

Jeoung, N. H. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.3.188 · Cited by 159

Therapeutic Potential of the Mammalian Pyruvate Dehydrogenase Kinases in the Prevention of Hyperglycaemia

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