The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome
Open accessAbstract
Glucocorticoids are stress hormones that modulate a large number of physiological actions involved in metabolic, inflammatory, cardiovascular and behavioral processes. The molecular mechanisms and the physiological effects of glucocorticoids have been extensively studied. However, the involvement of glucocorticoid action in the etiology of the Metabolic Syndrome has not been well appreciated. Recently, accumulating clinical evidence and animal genetics studies have attracted growing interest in the role of glucocorticoid action in obesity and insulin resistance. This review will discuss the metabolic effects in the context of glucocorticoid metabolism and establish the association of glucocorticoid action with the features of the Metabolic Syndrome, especially obesity and insulin resistance. Special discussions will be focused on corticosteroid-binding globulin and 11β-hydroxysteroid dehydrogenase type 1, two proteins that mediate glucocorticoid action and have been implicated in the Metabolic Syndrome. Due to the complexities of the glucocorticoid biology and the Metabolic Syndrome and limited space, this review is only intended to provide a general link between the two areas with broad rather than in-depth discussions of clinical, pharmacological and genetic findings.
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“Stress-induced elevations in glucocorticoids are associated with profound metabolic abnormalities including insulin resistance, glucose intolerance, dyslipidemia, increased central adiposity, and hypertension suggesting that chronic stress may in part contribute to the development of the MetS [66].”
BackgroundCircadian rhythm of adrenal glucocorticoid: its regulation and clinical implications
Chung, S., Son, G. H., & Kim, K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.003 · Cited by 305
Metadata
- Authors
- Wang, M.
- Venue
- Nutrition & Metabolism
- Published
- 2005-02-02
- Volume
- 2
- Issue
- 1
- Pages
- 3-3
- ISSN
- 1743-7075 (ISSN-L)
- OpenAlex
- W1610975395
- Cited by
- 277
- References
- 174
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
