Cited by 205Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorGenetic Associations and Epidemiology

The DOI matches its Crossref record; 94 of the 97 references it cites were found in a registry or an index.

The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis

Open access

Oades, Robert D., Lasky-Su, Jessica, Christiansen, Hanna, Faraone, Stephen V., Sonuga-Barke, Edmund J.S., Banaschewski, Tobias, Chen, Wai, Anney, Richard J.L., Buitelaar, Jan K., Ebstein, Richard P., Franke, Barbara, Gill, Michael, Miranda, Ana, Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph A., Steinhausen, Hans-Christoph, Taylor, Eric A., Thompson, Margaret, Asherson, Philip·2008·Behavioral and Brain Functions

DOI 10.1186/1744-9081-4-48PMC PMC2577091

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Low serotonergic (5-HT) activity correlates with increased impulsive-aggressive behavior, while the opposite association may apply to cognitive impulsiveness. Both types of impulsivity are associated with attention-deficit/hyperactivity disorder (ADHD), and genes of functional significance for the 5-HT system are implicated in this disorder. Here we demonstrate the separation of aggressive and cognitive components of impulsivity from symptom ratings and test their association with 5-HT and functionally related genes using a family-based association test (FBAT-PC). METHODS: Our sample consisted of 1180 offspring from 607 families from the International Multicenter ADHD Genetics (IMAGE) study. Impulsive symptoms were assessed using the long forms of the Conners and the Strengths and Difficulties parent and teacher questionnaires. Factor analysis showed that the symptoms aggregated into parent- and teacher-rated behavioral and cognitive impulsivity. We then selected 582 single nucleotide polymorphisms (SNPs) from 14 genes directly or indirectly related to 5-HT function. Associations between these SNPs and the behavioral/cognitive groupings of impulsive symptoms were evaluated using the FBAT-PC approach. RESULTS: In the FBAT-PC analysis for cognitive impulsivity 2 SNPs from the gene encoding phenylethanolamine N-methyltransferase (PNMT, the rate-limiting enzyme for adrenalin synthesis) attained corrected gene-wide significance. Nominal significance was shown for 12 SNPs from BDNF, DRD1, HTR1E, HTR2A, HTR3B, DAT1/SLC6A3, and TPH2 genes replicating reported associations with ADHD. For overt aggressive impulsivity nominal significance was shown for 6 SNPs from BDNF, DRD4, HTR1E, PNMT, and TPH2 genes that have also been reported to be associated with ADHD. Associations for cognitive impulsivity with a SERT/SLC6A4 variant (STin2: 12 repeats) and aggressive behavioral impulsivity with a DRD4 variant (exon 3: 3 repeats) are also described. DISCUSSION: A genetic influence on monoaminergic involvement in impulsivity shown by children with ADHD was found. There were trends for separate and overlapping influences on impulsive-aggressive behavior and cognitive impulsivity, where an association with PNMT (and arousal mechanisms affected by its activity) was more clearly involved in the latter. Serotonergic and dopaminergic mechanisms were implicated in both forms of impulsivity with a wider range of serotonergic mechanisms (each with a small effect) potentially influencing cognitive impulsivity. These preliminary results should be followed up with an examination of environmental influences and associations with performance on tests of impulsivity in the laboratory.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/1744-9081-4-48

Cites

94 of 94 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
The Strengths and Difficulties Questionnaire: A research note
Goodman, R. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01545.x · Cited by 14,908
Psychiatric Aspects of Impulsivity
Moeller, F. G., Barratt, E. S., Dougherty, D. M., Schmitz, J. M., & Swann, A. C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1783 · Cited by 2,747
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357
Self-citation
Varieties of impulsivity
Evenden, J. L. (1999) · Psychopharmacology · doi:10.1007/pl00005481 · Cited by 2,044
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., Clasen, L., Evans, A., Giedd, J., & Rapoport, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707741104 · Cited by 1,819
Temperament and developmental psychopathology
Nigg, J. T. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01612.x · Cited by 971
Attention, self–regulation and consciousness
The American Association for Research into Nervous and Mental Diseases, Posner, M. I., & Rothbart, M. K. (1998) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1998.0344 · Cited by 920
Behavioral models of impulsivity in relation to ADHD: Translation between clinical and preclinical studies
Winstanley, C. A., Eagle, D. M., & Robbins, T. W. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.01.001 · Cited by 893
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 862

Flagged first, then by citations

Show all 97 references

3 of the 97 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 205

Impulsivity and home-cage activity are decreased by lentivirus-mediated silencing of serotonin transporter in the rat hippocampus
Zoratto, F., Tringle, A. L., Bellenchi, G. C., Speranza, L., Travaglini, D., di Porzio, U., Perrone‐Capano, C., Laviola, G., Dreyer, J., & Adriani, W. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.076 · Cited by 17
Serotonin and Aggression
Quadros, I. M., Takahashi, A., & Miczek, K. A. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70106-5 · Cited by 18
Single nucleotide polymorphisms in the BDNF gene and suicide in the Slovenian sample
Ropret, S., Zupanc, T., Komel, R., & Paska, A. V. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.06.027 · Cited by 15
Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms
Ilješ, A. P., Plesničar, B. K., Kastelic, M., Porcelli, S., Serretti, A., & Dolžan, V. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.07.037 · Cited by 15
Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells
Hirono, M., Karube, F., & Yanagawa, Y. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.661899 · Cited by 16
Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands
Karmakar, A., Goswami, R., Saha, T., Maitra, S., Roychowdhury, A., Panda, C. K., Sinha, S., Ray, A., Mohanakumar, K. P., Rajamma, U., et al. (2017) · BMC Medical Genetics · doi:10.1186/s12881-017-0469-5 · Cited by 14
Association of night-waking and inattention/hyperactivity symptoms trajectories in preschool-aged children
Reynaud, È., Forhan, A., Heude, B., Charles, M.-A. A., & Plancoulaine, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33811-2 · Cited by 14
The Pediatric Microbiota–Gut–Brain Axis: Implications for Neuropsychiatric Development and Intervention
Marano, G., Sfratta, G., Marzo, E. M., Cozzo, G., Abate, F., Traversi, G., Mazza, O., Capristo, E., Gaetani, E., & Mazza, M. (2025) · Children · doi:10.3390/children12111561 · Cited by 18
Polymorphisms rs6313 and rs6314 in Serotonin Receptor Gene (HTR2A) and Serotonin Concentration in Autistic Children
Cieślińska, A., Fiedorowicz, E., Jarmołowska, B., Kordulewska, N. K., Kostyra, E., Moszyńska, M., & Savelkoul, H. F. J. (2019) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000547 · Cited by 13
Genetic Variation at the TPH2 Gene Influences Impulsivity in Addition to Eating Disorders
Landt, M., Bartels, M., Middeldorp, C. M., van Beijsterveldt, C. E. M., Slagboom, P. E., Boomsma, D. I., van Furth, E. F., & Meulenbelt, I. (2012) · Behavior Genetics · doi:10.1007/s10519-012-9569-3 · Cited by 14
Elevated levels of serotonin 5-HT2A receptors in the orbitofrontal cortex of antisocial individuals
Braccagni, G., Scheggi, S., & Bortolato, M. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01480-y · Cited by 12
Serotonergic modulation of normal and abnormal brain dynamics: The genetic influence of the TPH2 G-703T genotype and DNA methylation on wavelet variance in children and adolescents with and without ADHD
Akhrif, A., Romanos, M., Peters, K., Furtmann, A.-K., Caspers, J., Lesch, K., Meisenzahl‐Lechner, E., & Neufang, S. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282813 · Cited by 12
Variants in the Dopamine-4-Receptor Gene Promoter Are Not Associated with Sensation Seeking in Skiers
Thomson, C. J., Rajala, A. K., Carlson, S. R., & Rupert, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093521 · Cited by 13
Maoa and Maob polymorphisms and personality traits in suicide attempters and healthy controls: a preliminary study
Balestri, M., Calati, R., Serretti, A., Hartmann, A. M., Konte, B., Friedl, M., Giegling, I., & Rujescu, D. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.01.020 · Cited by 12
Coevolution of Residues Provides Evidence of a Functional Heterodimer of 5-HT2AR and 5-HT2CR Involving Both Intracellular and Extracellular Domains
Fongang, B., Cunningham, K. A., Rowicka, M., & Kudlicki, A. S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.05.013 · Cited by 14
A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder
Chatterjee, M., Saha, S., Sinha, S., & Mukhopadhyay, K. (2022) · World Journal of Pediatrics · doi:10.1007/s12519-022-00614-5 · Cited by 10
Faecal microbiota composition and impulsivity in a cohort of older adults with metabolic syndrome
Konstanti, P., Martínez, C. G., Muralidharan, J., Vioqué, J., Corella, D., Fitó, M., Vidal, J., Tinahones, F. J., Collado, L. T., Coltell, Ó., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-78527-8 · Cited by 11
A narrative review of research advances in gut microbiota and microecological agents in children with attention deficit hyperactivity disorder (ADHD)
Liu, Y., Zhang, P., & Sun, H. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1588135 · Cited by 14
Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-023-00727-1 · Cited by 10
Diagnostic et comorbidités des troubles du rythme veille-sommeil
Ruppert, É., & Kilic-Huck, Ü. (2018) · La Presse Médicale · doi:10.1016/j.lpm.2018.10.016 · Cited by 11
Serotonin and aggression—an update
Quadros, I. M., Takahashi, A., & Miczek, K. A. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00037-2 · Cited by 9
Beyond main effects of gene‐sets: harsh parenting moderates the association between a dopamine gene‐set and child externalizing behavior
Windhorst, D. A., Mileva‐Seitz, V. R., Rippe, R. C. A., Tiemeier, H. W., Jaddoe, V. W. V., Verhulst, F. C., van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2016) · Brain and Behavior · doi:10.1002/brb3.498 · Cited by 10
Modelling ADHD-Like Phenotypes in Zebrafish
Fontana, B. D., Norton, W., & Parker, M. O. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_343 · Cited by 9
Polymorphisms in dopaminergic genes predict proactive processes of response inhibition
Beu, N., Burns, N. R., & Baetu, I. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14323 · Cited by 11
A Systematic Review and Meta-Analysis Investigating the Relationship between Exposures to Chemical and Non-Chemical Stressors during Prenatal Development and Childhood Externalizing Behaviors
Nilsen, F. M., Frank, J. J., & Tulve, N. S. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072361 · Cited by 11
Unraveling the Contribution of Serotonergic Polymorphisms, Prefrontal Alpha Asymmetry, and Individual Alpha Peak Frequency to the Emotion-Related Impulsivity Endophenotype
Javelle, F., Löw, A., Bloch, W., Hosang, T. J., Jacobsen, T., Johnson, S. L., Schenk, A., & Zimmer, P. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02957-6 · Cited by 8
Molecular signature of excessive female aggression: study of stressed mice with genetic inactivation of neuronal serotonin synthesis
Strekalova, T. V., Moskvin, O. V., Jain, A. Y., Gorbunov, N., Вячеславовна, Г. А., Sadovnik, D. V., Umriukhin, A., Cespuglio, R., Yu, W. S., Tse, A. C.-K., et al. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02677-8 · Cited by 8
Heritability of Time Preference: Evidence from German Twin Data
Huebler, P. (2018) · Kyklos · doi:10.1111/kykl.12176 · Cited by 8
No causal role for the G482T and G689T polymorphisms in translation regulation of serotonin transporter (SLC6A4) or association with attention-deficit-hyperactivity disorder (ADHD)
Banerjee, E., Sinha, S., Chatterjee, A., & Nandagopal, K. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.032 · Cited by 7
Should we Keep on? Looking into Pharmacogenomics of ADHD in Adulthood from a Different Perspectives
Rovaris, D. L., Mota, N. R., da Silva, B. S., Girardi, P., Victor, M. M., Grevet, E. H., Bau, C. H. D., & Contini, V. (2014) · Pharmacogenomics · doi:10.2217/pgs.14.95 · Cited by 7
[An interaction between a polymorphism of the serotonin transporter (5HTT) gene and the clinical picture of adolescents with combined type ofADHD (hyperkinetic disorder) and youth drinking].
Gorzkowska, I., Gorzkowski, G., Samochowiec, A., Suchanecka, A., & Samochowiec, J. (2014) · PubMed · Cited by 7
REVERSE phenotyping—Can the phenotype following constitutive Tph2 gene inactivation in mice be transferred to children and adolescents with and without adhd?
Akhrif, A., Roy, A., Peters, K., Lesch, K., Romanos, M., Schmitt-Böhrer, A. G., & Neufang, S. (2021) · Brain and Behavior · doi:10.1002/brb3.2054 · Cited by 6
Pharmacogenomics of Neuropsychiatric Disorders: Analysis of Genetic Variability in 162 Identified Neuroreceptors using 1000 Genomes Project Data
Kaur, H., Jajodia, A., Grover, S., Agarwal, N., Baghel, R., & Kukreti, R. (2014) · Pharmacogenomics · doi:10.2217/pgs.14.113 · Cited by 5
MAOA Influences the Trajectory of Attentional Development
Lundwall, R. A., & Rasmussen, C. G. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00424 · Cited by 5
SLC6A3 Is Associated With Relational Aggression in Children
Lundwall, R. A., Sgro, J., & Wade, T. (2017) · Journal of Individual Differences · doi:10.1027/1614-0001/a000239 · Cited by 5
ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes
Brinksma, D. M., Hoekstra, P. J., de Bildt, A. A., Buitelaar, J. K., van den Hoofdakker, B. J., Hartman, C. A., & Dietrich, A. (2017) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-017-0377-3 · Cited by 5
Self-citation
Community matters: GxE interactions predicting childhood aggression and violent behavior
Sattler, L. J., Thomas, K. A., Vaughn, M. G., Almeida, J., White, L. A., & Waldman, M. R. (2019) · Journal of Criminal Justice · doi:10.1016/j.jcrimjus.2019.03.002 · Cited by 5
A Systems Biology Perspective on Childhood ADHD : Neurochemical Dysregulation, Brain‐Behavior Interactions, and Emerging Therapeutics
Alsoqih, N. S., Elmorsy, E. A., Abu‐Khudir, R., Saber, S., Keshk, N., Elnaghy, F., Hamad, R. S., El-kott, A. F., Negm, S., AlShehri, M. A., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202501829rr · Cited by 5
A preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disorders
Şener, E. F., Şahin, M. Ç., Taheri, S., Bayram, K. K., Maraşlı, M. K., Zararsız, G., Canpolat, M., Şahın, N., & Öztop, D. B. (2017) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2017.1293248 · Cited by 4
The Consequences of Neglect in Children: Neurocognitive Comparisons Among Conduct Disordered and Non-Conduct Disordered Youth Residing in Foster-Care with That of Children from Intact Families
Compton, D. M. (2013) · Psychology and Behavioral Sciences · doi:10.11648/j.pbs.20130203.13 · Cited by 4
Psychomotor agitation and mood instability in patients with autism spectrum disorders: A possible effect of SLC6A4 gene?
Schuch, J. B., Müller, D., Endres, R. G., Bosa, C. A., Longo, D., Schüler‐Faccini, L., Ranzan, J., Becker, M. M., Riesgo, R. D. S., & Roman, T. (2016) · Research in Autism · doi:10.1016/j.rasd.2016.03.001 · Cited by 6
Association between BDNF and Antidepressant Effects of Exercise in Youth: A Preliminary Study
Lim, Y. B., Kim, J. W., Hong, S., & Kim, J. (2016) · Journal of korean Academy of Child and Adolescent Psychiatry · doi:10.5765/jkacap.2016.27.1.72 · Cited by 5
The Implications of Maternal Obesity on Offspring Physiology and Behavior in the Nonhuman Primate
Sullivan, E. L., & Kievit, P. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6386-7_10 · Cited by 4
Specific dopaminergic genetic variants influence impulsivity, cognitive deficit, and disease severity of Indian ADHD probands
Maitra, S., Chatterjee, M., Roychowdhury, A., Panda, C. K., Sinha, S., & Mukhopadhyay, K. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07521-y · Cited by 4
Genetic factors and the brain in ADHD
Bralten, J. (2015) · Radboud Repository (Radboud University) · Cited by 3
The Role of Serotonin in Brain Development: From Molecular Pathways to Neurodevelopmental Risk
Chan, W. K., Rasmusson, S., Shiadeh, S. M. J., Wilhelmsson, R., Johansson, M. E., Elfving, B., Müller, H. K., Mallard, C. E., & Ardalan, M. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01746-2 · Cited by 2
Antisocialbehavior: gene–environment interplay
Baker, L. A., Tuvblad, C., Bezdjian, S., & Raine, A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139025997.014 · Cited by 2
Uncovering Disease-Related Polymorphisms through Correlations between SNP Frequencies, Population and Epidemiological Data
dos Reis, S. M., Bugs, C. A., Chies, J. A. B., & Cañedo, A. D. (2023) · BioMedInformatics · doi:10.3390/biomedinformatics3020032 · Cited by 2
Genetic Influence on Slope Variability in a Childhood Reflexive Attention Task
Lundwall, R. A., & Watkins, J. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130668 · Cited by 3
Impulsivity in anxiety disorders
Carlo, A. D., Benvenuti, M., Dima, F., Cesari, D., Rizzato, S., Casalini, F., Dell’Osso, L., & Perugi, G. (2012) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000423334.62343.80 · Cited by 2
Shared risk factors for intermittent explosive disorder, attention deficit hyperactivity disorder and conduct disorder: A systematic reviewPreprint
Liu, F., & Yin, X. (2025) · Research Square · doi:10.21203/rs.3.rs-6178867/v1 · Cited by 2
Republication de : Diagnostic et comorbidités des troubles du rythme veille-sommeil
Ruppert, É., & Kilic-Huck, Ü. (2019) · Médecine du Sommeil · doi:10.1016/j.msom.2018.12.002 · Cited by 1
Sex-specific effects of chronic caffeine on impulsive choice and serotonergic markers in an ADHD rat model
Almeida, A. S., Marques, D. M., MARTINS, B. C. B., Masschmann, H., Alves, C. B., de Lara, M. V. S., & Porciúncula, L. O. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07050-7 · Cited by 1
Comorbidity in ADHD: A Neuropsychological Perspective
Lázaro, J. C. F., & Soruco, M. A. S. (2012) · InTech eBooks · doi:10.5772/30697 · Cited by 3
A decade of contributions to understanding and ameliorating attention deficit-hyperactivity disorder
Killeen, P. R. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0097-9 · Cited by 1
Functional Neuroimaging Evidence Supporting Neurofeedback in ADHD
Lévesque, J., & Beauregard, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-382235-2.00013-5 · Cited by 1
Thinking about thinking in paediatric critical care
Mehta, H., & Plunkett, A. (2021) · Paediatrics and Child Health · doi:10.1016/j.paed.2021.03.003 · Cited by 1
The influence of maternal high-fat diet consumption on neurobehavioral development
Mitchell, A. J., Selby, M., & Sullivan, E. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817986-4.00051-1 · Cited by 1
Neurobiologiczne i psychospołeczne uwarunkowania racjonalności zachowań przestępczych – przegląd badań
Piotrowski, P. (2011) · The Repository of University in Bialystok (University in Bialystok) · Cited by 1
Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genesPreprint
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.23.541950 · Cited by 1
Efeitos da intoxicação progressiva e aguda de chumbo sobre parâmetros comportamentais do Betta Splends: escototaxia e display agressivo
dos Santos, B. R. (2009) · Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences
Oppositional Defiant Disorder to Biological Research
王, 长. (2012) · International Journal of Psychiatry and Neurology · doi:10.12677/ijpn.2012.14009
Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward
Oscar‐Berman, M., Blum, K., & Gold, M. S. (2012)
Oppositional Defiant Disorder to Biological Research
Wang, C., Ning, Q.-F., Liu, M., Wang, D., Li, Y., & Yang, J. (2012)
A Developmental Perspective on Attention-Defity Disorder (ADHD)
Campbell, S. B. G., Halperin, J. M., & Sonuga-Barke, E. J. S. (2014)
Self-citation
Komorbide Störungen bei der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung unter Berücksichtigung des Einflusses von Expressed Emotion
Christiansen, H. (2009) · Publikationsserver (Universitat Marburg) · doi:10.17192/z2009.0162
Self-citation
The Effects of Childhood Irritability on Adolescent Outcomes and Treatment Response in Children with Attention-Deficit/Hyperactivity Disorder
Heber, E. (2017) · CUNY Academic Works (City University of New York)
Exploring the Role of BDNF and NTRK2 Genetic Polymorphisms on Eating Behaviours in Young Children
Lee, Y. K. M. (2017) · TSpace (University of Toronto)
Genetics of impulsivity, anger, and aggression as risk factors for suicidal behavior
Rujescu, D., & Giegling, I. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780198793014.003.0023
The Cognitive Processes Involved in Diagnosis
Ohta, M. (2021) · Japanese Journal of Oral Diagnosis / Oral Medicine · doi:10.15214/jsodom.34.1
In silico, in vitro, in vivo and in populo: Regulatory genetics of single nucleotide polymorphisms in the phenylethanolamine N-methyltransferase promoter
Flores, R., & Lorenzo, J. C. (2009)
Decision Making and Pediatric Bipolar Disorder Assessment/Diagnosis: A Phenomenographic Study
Davies, K. (2015) · ScholarWorks (Walden University)
Caracterização de rearranjos cromossômicos citogeneticamente equilibrados associados a quadros clínicos
Fonseca, A. C. D. S. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2016.tde-05052016-112830
Maternal Obesity and ADHD: An Original Review of Evidence and Potential Mechanisms
Boueri, M. G., Fakhouri, M., Aoun, C., & Matar, M. (2023) · The Journal of Pediatric Academy · doi:10.4274/jpea.2023.256
Medication affecting the correlation of aggression development and Attention-Deficit/Hyperactivity Disorder (ADHD)
Wang, T. (2024) · Theoretical and Natural Science · doi:10.54254/2753-8818/44/20240858
Neurochemical Mechanisms of Addiction
Nemets, V. V., Grinevich, V. P., & Gainetdinov, R. R. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700394
Animal models of attention-deficit/hyperactivity disorder: Diversity and validity
Nehme, S. B. S., Sánchez‐Sarasúa, S., Medrano, M., Bouchatta, O., Bitar, T., Alameddine, A., Galineau, L., Brunault, P., Kerekes, N., Sánchez‐Pérez, A. M., et al. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100108
Additional file 2 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.24934631
Additional file 15 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658787
Additional file 1 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.24934423
Additional file 6 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658760
Additional file 5 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658757
Additional file 4 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658751
Additional file 17 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658796
Additional file 16 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658793
Additional file 3 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658748
Additional file 7 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658763
Additional file 19 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658802
Additional file 12 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658778
Additional file 13 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658781
Additional file 20 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658805
Additional file 14 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658784
Additional file 10 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658772
Additional file 11 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658775
Additional file 21 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658808
Additional file 18 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658799
Additional file 8 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658766
Additional file 9 of Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes
Fisher, J. L., Clark, A. D., Jones, E. F., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26658769
A systematic review and a meta-analysis of genetic studies linking dopaminergic alleles to aggression: Where are we now?
Palumbo, S., Grassi, G., Mariotti, V., & Pellegrini, S. (2025) · Aggression and Violent Behavior · doi:10.1016/j.avb.2025.102096
Aniracetam restores the excitation-inhibition balance of neurotransmitters in the prefrontal cortex of mice with ADHD
Cui, J., Sun, X.-L., Shi, S., Bai, H., Zhang, W., & Bai, W. (2026) · Scientific Reports · doi:10.1038/s41598-026-38725-y

Authors: Oades, R. D., Lasky-Su, J., Christiansen, H., Faraone, S. V., Sonuga-Barke, E. J. S., Banaschewski, T., Chen, W., Anney, R. J. L., Buitelaar, J. K., Ebstein, R. P., Franke, B., Gill, M., Miranda, A., Roeyers, H., Rothenberger, A., Sergeant, J. A., Steinhausen, H.-C., Taylor, E. A., Thompson, M., & Asherson, P.
Affiliations: University of Duisburg-Essen (DE)
Brigham and Women's Hospital (US)
SUNY Upstate Medical University (US)
Ghent University (BE)
Central Institute of Mental Health (DE)
University of Southampton (GB)
St. James's Hospital (IE)
Radboud University Nijmegen (NL)
Herzog Hospital (IL)
Universitat de València (ES)
University of Göttingen (DE)
Vrije Universiteit Amsterdam (NL)
University of Zurich (CH)
Corresponding author: Oades, Robert D.
ORCID: Lasky-Su, Jessica
Christiansen, Hanna
Faraone, Stephen V.
Sonuga-Barke, Edmund J.S.
Banaschewski, Tobias
Chen, Wai
Anney, Richard J.L.
Buitelaar, Jan K.
Ebstein, Richard P.
Franke, Barbara
Gill, Michael
Miranda, Ana
Roeyers, Herbert
Rothenberger, Aribert
Sergeant, Joseph A.
Steinhausen, Hans-Christoph
Taylor, Eric A.
Thompson, Margaret
Asherson, Philip
Venue: Behavioral and Brain Functions
Publisher: Springer Science and Business Media LLC
Published: 2008
Volume: 4
Issue: 1
Pages: 48
ISSN: 1744-9081 (ISSN-L)
DOI: 10.1186/1744-9081-4-48
PMC: PMC2577091
OpenAlex: W2126107189
Cited by: 200
References: 97
Citations by year: 2026: 6 · 2025: 8 · 2024: 20 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 6 · 2017: 12 · 2016: 13 · 2015: 16 · 2014: 11 · 2013: 9 · 2012: 21
FWCI: 10.07
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Behavioral and Brain Functions (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
UWA Profiles and Research Repository (UWA) (submittedVersion, other-oa)
National University of Singapore (submittedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
DuEPublico (University of Duisburg-Essen) (submittedVersion, cc-by)
ePrints Soton (University of Southampton) (submittedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
GRO (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: University of Southampton
Radboud Universiteit
National Institutes of Health
Medical Research Council
Economic and Social Research Council
National Institute of Mental Health (R01MH062873)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: impulsivity, cognitive impulsivity, serotonin, phenylethanolamine N-methyltransferase, brain-derived neurotrophic factor, dopamine receptor genes, HTR2A, HTR3B, tryptophan hydroxylase 2, monoaminergic systems, single nucleotide polymorphisms, genetic association

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks