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Cited by 228Cardiac Health and Mental HealthCardiovascular and exercise physiologyCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

A Meta-analysis of the effects of Exercise Training on Left Ventricular Remodeling Following Myocardial Infarction: Start early and go longer for greatest exercise benefits on remodeling

Open access
Haykowsky, Mark, Scott, Jessica, Esch, Ben, Schopflocher, Don, Myers, Jonathan, Paterson, Ian, Warburton, Darren, Jones, Lee, Clark, Alexander M·2011·Trials
DOI 10.1186/1745-6215-12-92PMC PMC3083361
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Abstract

BACKGROUND: The effects of variations in exercise training on left ventricular (LV) remodeling in patients shortly after myocardial infarction (MI) are important but poorly understood. METHODS: Systematic review incorporating meta-analysis using meta-regression. Studies were identified via systematic searches of: OVID MEDLINE (1950 to 2009), Cochrane Central Register of Controlled Trials (1991 to 2009), AMED (1985 to 2009), EMBASE (1988 to 2009), PUBMED (1966 to 2009), SPORT DISCUS (1975 to 2009), SCOPUS (1950 to 2009) and WEB OF SCIENCE (1950 to 2009) using the medical subject headings: myocardial infarction, post myocardial infarction, post infarction, heart attack, ventricular remodeling, ventricular volumes, ejection fraction, left ventricular function, exercise, exercise therapy, kinesiotherapy, exercise training. Reference lists of all identified studies were also manually searched for further relevant studies. Studies selected were randomized controlled trials of exercise training interventions reporting ejection fraction (EF) and/or ventricular volumes in patients following recent MI (≤ 3 months) post-MI patients involving control groups. Studies were excluded if they were not randomized, did not have a 'usual-care' control (involving no exercise), evaluated a non-exercise intervention, or did not involve human subjects. Non-English studies were also excluded. RESULTS: After screening of 1029 trials, trials were identified that reported EF (12 trials, n = 647), End Systolic Volumes (ESV) (9 trials, n = 475) and End Diastolic Volumes (EDV) (10 trials, n = 512). Meta-regression identified that changes in EF effect size difference decreased as the time between MI and initiation of the exercise program lengthened, and increased as the duration of the program increased (Q = 25.48, df = 2, p < 0.01, R2 = 0.76). Greater reductions in ESV and EDV (as indicated by effect size decreases) occurred with earlier initiation of exercise training and with longer training durations (ESV: Q = 23.89, df = 2, p < 0.05, R2 = 0.79; EDV: Q = 27.42, df = 2, p < 0.01, R2 = 0.83). Differences remained following sensitivity analysis. Each week that exercise was delayed required an additional month of training to achieve the same level of benefit on LV remodeling. CONCLUSIONS: Exercise training has beneficial effects on LV remodeling in clinically stable post-MI patients with greatest benefits occurring when training starts earlier following MI (from one week) and lasts longer than 3 months.

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Crossref · 10.1186/1745-6215-12-92

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Figure 1 Flow of trials through the selection process.
Figure 1 Flow of trials through the selection process.CC BY · PubMed Central
Figure 2 EF effect size difference for individual trials categorized by time to exercise training and duration of training program.
Figure 2 EF effect size difference for individual trials categorized by time to exercise training and duration of training program.CC BY · PubMed Central
Figure 3 ESV effect size difference for individual trials categorized by time to exercise training and duration of training program.
Figure 3 ESV effect size difference for individual trials categorized by time to exercise training and duration of training program.CC BY · PubMed Central
Figure 4 EDV effect size difference for individual trials categorized by time to exercise training and duration of training program.
Figure 4 EDV effect size difference for individual trials categorized by time to exercise training and duration of training program.CC BY · PubMed Central

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Research works printed but not linked: 2

  1. Parker k, Hauer T, Arena R, Lundberg D, Aggarwal S, Goodhart D, D. T: Attendance in an early discharge clinic with symptom limited maximal exercise testing is safe and improves cardiac rehabilitation participation among low-risk stemi patients. Eur J Cardiovasc Prev Rehabil. 2009, 16:
  2. Clark AM, Hartling L, Vandermeer B, McAlister FA: Secondary prevention program for patients with coronary artery disease: A meta-analysis of randomized control trials. Ann Int Med. 2005, 143: 659-672. · DOI · Paper page

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Metadata

Authors
Haykowsky, M., Scott, J., Esch, B., Schopflocher, D., Myers, J., Paterson, I., Warburton, D., Jones, L., & Clark, A. M.
Affiliations
  • University of Alberta (CA)
  • University of British Columbia (CA)
  • VA Palo Alto Health Care System (US)
  • Duke Medical Center (US)
Corresponding author
Haykowsky, Mark
ORCID
Venue
Trials
Publisher
Springer Science and Business Media LLC
Published
2011-04-04
Volume
12
Issue
1
Pages
92-92
ISSN
1745-6215 (ISSN-L)
DOI
10.1186/1745-6215-12-92
PMC
PMC3083361
OpenAlex
W2132363115
Cited by
228
References
40
Citations by year
2026: 7 · 2025: 10 · 2024: 23 · 2023: 17 · 2022: 18 · 2021: 22 · 2020: 17 · 2019: 18 · 2018: 15 · 2017: 13 · 2016: 19 · 2015: 12 · 2014: 13 · 2013: 8 · 2012: 14
FWCI
1.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Trials (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion)
  • cIRcle (University of British Columbia) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • U.S. Department of Veterans Affairs (IK6 RX002477)
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
exercise training, left ventricular remodeling, myocardial infarction, ejection fraction, end-systolic volume, end-diastolic volume, training duration, cardiac rehabilitation, left ventricular function, ventricular volume
MeSH terms
Exercise Therapy, Humans, Myocardial Infarction, Stroke Volume, Time Factors, Ventricular Function, Left, Treatment Outcome, Evidence-Based Medicine, Ventricular Remodeling

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