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Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study

Open access
Sartelli, Massimo, Catena, Fausto, Ansaloni, Luca, Coccolini, Federico, Corbella, Davide, Moore, Ernest E, Malangoni, Mark, Velmahos, George, Coimbra, Raul, Koike, Kaoru, Leppaniemi, Ari, Biffl, Walter, Balogh, Zsolt, Bendinelli, Cino, Gupta, Sanjay, Kluger, Yoram, Agresta, Ferdinando, Saverio, Salomone Di, Tugnoli, Gregorio, Jovine, Elio, Ordonez, Carlos A, Whelan, James F, Fraga, Gustavo P, Gomes, Carlos Augusto, Pereira, Gerson Alves, Yuan, Kuo-Ching, Bala, Miklosh, Peev, Miroslav P, Ben-Ishay, Offir, Cui, Yunfeng, Marwah, Sanjay, Zachariah, Sanoop, Wani, Imtiaz, Rangarajan, Muthukumaran, Sakakushev, Boris, Kong, Victor, Ahmed, Adamu, Abbas, Ashraf, Gonsaga, Ricardo Alessandro Teixeira, Guercioni, Gianluca, Vettoretto, Nereo, Poiasina, Elia, Díaz-Nieto, Rafael, Massalou, Damien, Skrovina, Matej, Gerych, Ihor, Augustin, Goran, Kenig, Jakub, Khokha, Vladimir, Tranà, Cristian, Kok, Kenneth Yuh Yen, Mefire, Alain Chichom, Lee, Jae Gil, Hong, Suk-Kyung, Lohse, Helmut Alfredo Segovia, Ghnnam, Wagih, Verni, Alfredo, Lohsiriwat, Varut, Siribumrungwong, Boonying, El Zalabany, Tamer, Tavares, Alberto, Baiocchi, Gianluca, Das, Koray, Jarry, Julien, Zida, Maurice, Sato, Norio, Murata, Kiyoshi, Shoko, Tomohisa, Irahara, Takayuki, Hamedelneel, Ahmed O, Naidoo, Noel, Adesunkanmi, Abdul Rashid Kayode, Kobe, Yoshiro, Ishii, Wataru, Oka, Kazuyuki, Izawa, Yoshimitsu, Hamid, Hytham, Khan, Iqbal, Attri, AK, Sharma, Rajeev, Sanjuan, Juan, Badiel, Marisol, Barnabé, Rita·2014·World Journal of Emergency Surgery

Abstract

The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).

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Authors
Sartelli, M., Catena, F., Ansaloni, L., Coccolini, F., Corbella, D., Moore, E. E., Malangoni, M., Velmahos, G., Coimbra, R., Koike, K., Leppaniemi, A., Biffl, W., Balogh, Z., Bendinelli, C., Gupta, S., Kluger, Y., Agresta, F., Saverio, S. D., Tugnoli, G., Jovine, E., Ordonez, C. A., Whelan, J. F., Fraga, G. P., Gomes, C. A., Pereira, G. A., Yuan, K.-C., Bala, M., Peev, M. P., Ben-Ishay, O., Cui, Y., Marwah, S., Zachariah, S., Wani, I., Rangarajan, M., Sakakushev, B., Kong, V., Ahmed, A., Abbas, A., Gonsaga, R. A. T., Guercioni, G., Vettoretto, N., Poiasina, E., Díaz-Nieto, R., Massalou, D., Skrovina, M., Gerych, I., Augustin, G., Kenig, J., Khokha, V., Tranà, C., Kok, K. Y. Y., Mefire, A. C., Lee, J. G., Hong, S.-K., Lohse, H. A. S., Ghnnam, W., Verni, A., Lohsiriwat, V., Siribumrungwong, B., El Zalabany, T., Tavares, A., Baiocchi, G., Das, K., Jarry, J., Zida, M., Sato, N., Murata, K., Shoko, T., Irahara, T., Hamedelneel, A. O., Naidoo, N., Adesunkanmi, A. R. K., Kobe, Y., Ishii, W., Oka, K., Izawa, Y., Hamid, H., Khan, I., Attri, A., Sharma, R., Sanjuan, J., Badiel, M., & Barnabé, R.
Venue
World Journal of Emergency Surgery
Published
2014-05-14
Volume
9
Issue
1
Pages
37-37
ISSN
1749-7922 (ISSN-L)
OpenAlex
W2108565421
Cited by
313
References
21
FWCI
17.20
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study. https://app.cochat.ai/papers/10.1186/1749-7922-9-37
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Sartelli, M., Catena, F., Ansaloni, L., Coccolini, F., Corbella, D., Moore, E. E., Malangoni, M., Velmahos, G., Coimbra, R., Koike, K., Leppaniemi, A., Biffl, W., Balogh, Z., Bendinelli, C., Gupta, S., Kluger, Y., Agresta, F., Saverio, S. D., Tugnoli, G., . . . Barnabé, R. (2014). Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study. World Journal of Emergency Surgery. https://doi.org/10.1186/1749-7922-9-37

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