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Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)
Open accessAbstract
Andrographis paniculata (Burm. f.) Nees (Acanthaceae) is a medicinal plant used in many countries. Its major constituents are diterpenoids, flavonoids and polyphenols. Among the single compounds extracted from A. paniculata, andrographolide is the major one in terms of bioactive properties and abundance. Among the andrographolide analogues, 14-deoxy-11,12-didehydroandrographolide is immunostimulatory, anti-infective and anti-atherosclerotic; neoandrographolide is anti-inflammatory, anti-infective and anti-hepatotoxic; 14-deoxyandrographolide is immunomodulatory and anti-atherosclerotic. Among the less abundant compounds from A. paniculata, andrograpanin is both anti-inflammatory and anti-infective; 14-deoxy-14,15-dehydroandrographolide is anti-inflammatory; isoandrographolide, 3,19-isopropylideneandrographolide and 14-acetylandrographolide are tumor suppressive; arabinogalactan proteins are anti-hepatotoxic. The four flavonoids from A. paniculata, namely 7-O-methylwogonin, apigenin, onysilin and 3,4-dicaffeoylquinic acid are anti-atherosclerotic.
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O’Keefe, J. H., Gheewala, N. M., & O’Keefe, J. O. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.016 · Cited by 497 · cited 1×
“Effective modulation of the aberrant production of these molecules may reduce inflammation [24,25].”
Cited by
Dai, Y., Chen, S.-R., Chai, L., Zhao, J., Wang, Y., & Wang, Y. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1501657 · Cited by 323
Okhuarobo, A., Ehizogie Falodun, J., Erharuyi, O., Imieje, V., Falodun, A., & Langer, P. (2014) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(14)60509-0 · Cited by 289
Lim, J. C. W., Chan, T. K., Ng, D. S., Sagineedu, S. R., Stanslas, J., & Wong, W. F. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05633.x · Cited by 268
Fitrasyah, S. I., Ariani, A., Rahman, N., Nurulfuadi, N., Aiman, U., Nadila, D., Pradana, F., Rakhman, A., & Hartini, D. A. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.5872 · Cited by 12
Metadata
- Authors
- Chao, W.-W., & Lin, B.-F.
- Venue
- Chinese Medicine
- Published
- 2010
- Volume
- 5
- Issue
- 1
- Pages
- 17
- ISSN
- 1749-8546 (ISSN-L)
- OpenAlex
- W2168763969
- Cited by
- 390
- References
- 1
- FWCI
- 21.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chao, W.-W., & Lin, B.-F. (2010). Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chinese Medicine. https://doi.org/10.1186/1749-8546-5-17
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