Cited by 203Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversionBiochemical and biochemical processes

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Zymomonas mobilis: a novel platform for future biorefineries

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He, Ming, Wu, Bo, Qin, Han, Ruan, Zhi, Tan, Fu, Wang, Jing, Shui, Zong, Dai, Li, Zhu, Qi, Pan, Ke, Tang, Xiao, Wang, Wen, Hu, Qi·2014·Biotechnology for Biofuels

DOI 10.1186/1754-6834-7-101PMC PMC4094786

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Abstract

Biosynthesis of liquid fuels and biomass-based building block chemicals from microorganisms have been regarded as a competitive alternative route to traditional. Zymomonas mobilis possesses a number of desirable characteristics for its special Entner-Doudoroff pathway, which makes it an ideal platform for both metabolic engineering and commercial-scale production of desirable bio-products as the same as Escherichia coli and Saccharomyces cerevisiae based on consideration of future biomass biorefinery. Z. mobilis has been studied extensively on both fundamental and applied level, which will provide a basis for industrial biotechnology in the future. Furthermore, metabolic engineering of Z. mobilis for enhancing bio-ethanol production from biomass resources has been significantly promoted by different methods (i.e. mutagenesis, adaptive laboratory evolution, specific gene knock-out, and metabolic engineering). In addition, the feasibility of representative metabolites, i.e. sorbitol, bionic acid, levan, succinic acid, isobutanol, and isobutanol produced by Z. mobilis and the strategies for strain improvements are also discussed or highlighted in this paper. Moreover, this review will present some guidelines for future developments in the bio-based chemical production using Z. mobilis as a novel industrial platform for future biofineries.

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Figure 1 Selected milestones in Z. mobilis research.CC BY · PubMed Central

Figure 2 Research history of recombinant Z. mobilis for ethanol production.CC BY · PubMed Central

Figure 3 Reaction scheme for the production of bionic acid and sorbitol via glucose-fructose oxidoreductase (GFOR) and glucono-σ-lactonase(GL) of Z. mobilis.CC BY · PubMed Central

Figure 4 Metabolic pathways for the production of the high-value products by using Z. mobilis as platform. The solid lines indicate Z. mobilis native pathways and the dotted lines refer to the recombinant pathway obtained by metabolic engineering strategies. gfor, glucose-fructose oxidoreductase; ldhA, lactate dehydrogenase; pdc, pyruvate decarboxylase; gnl, glucono-σ-gluconase; adc, acetoacetate dehydrogenase; adh, secondary alcohol dehydrogenase; adhB, alcohol dehydrogenase; adhE, acetaldehyde/alcohol dehydrogenase; adhE2, secondary alcohol dehydrogenase; atoAD, acetyl-CoA:acetoacetyl-CoA transferase; atoB, acetyl-CoA acyltransferase; bcd, butyryl-CoA dehydrogenase; crt, crotonase; ctfAB, acetoacetyl-CoA transferase; etfBA, electrotransfer flavor protein; hbd, β-hydroxy butyryl-CoA dehydrogenase; thl, acetyl-CoA acyltransferase; kivd, ketoisovalerate decarboxylase.CC BY · PubMed Central

Figure 5 General process of fuel or chemical production by Z. mobilis .CC BY · PubMed Central

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Authors: He, M., Wu, B., Qin, H., Ruan, Z., Tan, F., Wang, J., Shui, Z., Dai, L., Zhu, Q., Pan, K., Tang, X., Wang, W., & Hu, Q.
Affiliations: Biogas Institute of Ministry of Agriculture (CN)
Institute of Agricultural Resources and Regional Planning (CN)
ORCID: Wu, Bo
Wang, Jing
Zhu, Qi
Wang, Wen
Venue: Biotechnology for Biofuels
Publisher: Springer Science and Business Media LLC
Published: 2014
Volume: 7
Issue: 1
Pages: 101
ISSN: 1754-6834 (ISSN-L)
DOI: 10.1186/1754-6834-7-101
PMC: PMC4094786
OpenAlex: W2172228379
Cited by: 203
References: 178
Citations by year: 2026: 4 · 2025: 8 · 2024: 12 · 2023: 23 · 2022: 16 · 2021: 35 · 2020: 18 · 2019: 17 · 2018: 20 · 2017: 16 · 2016: 19 · 2015: 12 · 2014: 3
FWCI: 1.57
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Biotechnology for Biofuels (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Shandong University
National Natural Science Foundation of China (201403019, 31000028)
Chinese Academy of Agricultural Sciences (201403019)
Tarim University
Special Fund for Agro-scientific Research in the Public Interest (201403019)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Biochemical and biochemical processes
Keywords: Zymomonas mobilis, Entner-Doudoroff pathway, metabolic engineering, bioethanol production, bio-based chemicals, sorbitol, levan, succinic acid, isobutanol, adaptive laboratory evolution, gene knockout, industrial biotechnology

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Zymomonas mobilis: a novel platform for future biorefineries

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