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Cited by 17Thyroid Disorders and TreatmentsBone health and osteoporosis researchBone Metabolism and Diseases

Negative correlation between bone mineral density and TSH receptor antibodies in long-term euthyroid postmenopausal women with treated Graves’ disease

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Ercolano, Monica A, Drnovsek, Monica L, Croome, Maria C Silva, Moos, Monica, Fuentes, Ana M, Viale, Fanny, Feldt-Rasmussen, Ulla, Gauna, Alicia T·2013·Thyroid Research
DOI 10.1186/1756-6614-6-11PMC PMC3847206
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Abstract

BACKGROUND: Thyrotoxicosis is a cause of secondary osteoporosis. High concentrations of triiodotironine (T3) in Graves' disease stimulate bone turnover, but it is unclear if euthyroidism will always normalize bone metabolism. Thyrotropin (TSH) is known to affect directly the bone metabolism through the TSH receptor and TSH receptor antibodies (TRAb) may have an important role in bone turn-over.The aim of our study was to determine, in pre and postmenopausal euthyroidism patients with previous overt hyperthyroidism due to Graves' disease the bone mineral density (BMD) as well as factors that could affect BMD in each group, including TRAb. METHODS: Cross-sectional, non-interventional study. Fifty-seven patients with previous hyperthyroidism due to Graves' disease (premenopausal: 30, postmenopausal: 27) that remained euthyroid for at least 6 months prior to study were included and compared with fifty- two matched respective controls. Thyrotoxine (T4), TSH, TRAb and BMD were measured. RESULTS: Only euthyroid postmenopausal patients with a history of hyperthyroidism due to Graves' disease showed lower whole body BMD than matched controls. The BMD expressed as Z-score was less in whole body and lumbar spine in postmenopausal in relation to premenopausal women with previous overt hyperthyroidism due to Graves' disease.In the postmenopausal patients, the Z-score of lumbar spine BMD correlated negatively with TRAb (r = -0,53, p < 0.008), positively with the time of evolution of the disease (r = +0.42, p < 0.032) and positively with the time of euthyroidism (r = + 0.50, p < 0.008), but neither with serum T4 nor TSH. In a multiple regression analysis TRAb was the only significant independent variable in relation to lumbar spine BMD (F = 3. 90, p < 0.01). CONCLUSIONS: In euthyroid women with a history of Graves' hyperthyroidism, BMD was only affected in the postmenopausal group. The negative correlation of Z-score of lumbar spine BMD with TRAb suggests that this antibody may affect the bone metabolism.

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  • In euthyroid women with a history of Graves' hyperthyroidism, lumbar spine bone density is negatively associated with TSH receptor antibodies in postmenopausal but not premenopausal women.

    “in euthyroid women with a history of Graves’ hyperthyroidism lumbar spine bone density was negatively associated with TSH receptor antibodies in post- but not premenopausal women (102).”

    From Levothyroxine therapy in elderly patients with hypothyroidism (2021) · cites this paper as [102]

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Authors
Ercolano, M. A., Drnovsek, M. L., Croome, M. C. S., Moos, M., Fuentes, A. M., Viale, F., Feldt-Rasmussen, U., & Gauna, A. T.
Affiliations
Hospital Ramos Mejía (AR)
ORCID
Gauna, Alicia T
Venue
Thyroid Research
Publisher
Springer Science and Business Media LLC
Published
2013
Volume
6
Issue
1
Pages
11
ISSN
1756-6614 (ISSN-L)
DOI
10.1186/1756-6614-6-11
PMC
PMC3847206
OpenAlex
W2130828493
Cited by
17
References
49
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 1
FWCI
0.79
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Thyroid Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
bone mineral density, TSH receptor antibodies, Graves' disease, postmenopausal women, secondary osteoporosis, bone metabolism, lumbar spine, euthyroidism, hyperthyroidism, TSH receptor, bone turnover

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