CoChat
Sign Up
Cited by 30Bone health and osteoporosis researchThyroid Disorders and TreatmentsHIV-related health complications and treatments

Hyperthyroidism Influences Ultrasound Bone Measurement on the Os Calcis

Gómez Acotto, C., Schott, A. M., Hans, D., Niepomniszcze, H., Mautalen, C. A., Meunier, P. J.·1998·Osteoporosis International
DOI 10.1007/s001980050091
Open this paper in CoChat — free account

Abstract

The objective of our study was to compare bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) and quantitative ultrasound (QUS) parameters in women with hyperthyroidism and controls. In this cross-sectional study, QUS parameters and BMD values observed in untreated hyperthyroid patients were compared with data obtained from age-matched controls. Twenty-four women with Graves' disease were studied. Eight patients were postmenopausal. All patients had evidence of thyrotoxicosis as indicated by a raised total serum thyroxine and a suppressed serum thyroid stimulating hormone. BMD of the hip, lumbar spine and whole body, and body composition, were measured by DXA. Ultrasound evaluation on the os calcis was performed with an Achilles device. All measurements were performed before antithyroid therapy. The QUS parameters of BUA, SOS and Stiffness were significantly lower in hyperthyroid patients than in controls. Similar results were observed for the BMD of lumbar spine, femoral neck and total skeleton. Lean tissue and fat mass were also significantly decreased in hyperthyroid patients. In conclusion, these findings suggest that hyperthyroidism affects cortical and trabecular bone equally, as well as bone quality. QUS measurements may be helpful for assessing, using a simple and non-irradiating method, the bone effects of thyrotoxicosis.

Integrity signals

Registry

Crossref · 10.1007/s001980050091

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Iatrogenic hyperthyroidism can decrease bone quality and bone mineral density, leading to a higher risk of fracture.

    “which can decrease bone quality22 and bone mineral density,60 leading to a higher risk of fracture.”

    From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [22]

  • Higher compared with lower doses of levothyroxine replacement are associated with lower bone density and bone quality, as measured by ultrasonography.

    “Studies have found that higher compared with lower doses of levothyroxine replacement18 19 20 and subclinical hyperthyroidism21 are associated with a lower bone density and bone quality, as measured by ultrasonography.22”

    From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [22]

  • Subclinical hyperthyroidism is associated with lower bone density and bone quality, as measured by ultrasonography.

    “Studies have found that higher compared with lower doses of levothyroxine replacement18 19 20 and subclinical hyperthyroidism21 are associated with a lower bone density and bone quality, as measured by ultrasonography.22”

    From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [22]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Gómez Acotto, C., Schott, A. M., Hans, D., Niepomniszcze, H., Mautalen, C. A., & Meunier, P. J.
Affiliations
Hôpital Edouard Herriot (FR)
ORCID
Venue
Osteoporosis International
Publisher
Springer Science and Business Media LLC
Published
1998-08-01
Volume
8
Issue
5
Pages
455-459
ISSN
  • 0937-941X (ISSN-L)
  • 1433-2965
DOI
10.1007/s001980050091
OpenAlex
W1978227261
Cited by
30
References
18
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 2
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Osteoporosis International (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Keywords
hyperthyroidism, Graves' disease, quantitative ultrasound, bone mineral density, calcaneus, Achilles tendon, bone quality, bone stiffness, body composition, postmenopausal women, thyrotoxicosis, cortical and trabecular bone
MeSH terms
Adult, Aged, Aged, 80 and over, Body Composition, Calcaneus, Cross-Sectional Studies, Female, Femur Neck, Graves Disease, Humans, Lumbar Vertebrae, Middle Aged, Osteoporosis, Ultrasonography, Absorptiometry, Photon, Bone Density

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review