The DOI matches its Crossref record; 497 of the 497 references it cites were found in a registry or an index.
Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
Open accessAbstract
In this review we propose that there are sex differences in how men and women enter onto the path that can lead to addiction. Males are more likely than females to engage in risky behaviors that include experimenting with drugs of abuse, and in susceptible individuals, they are drawn into the spiral that can eventually lead to addiction. Women and girls are more likely to begin taking drugs as self-medication to reduce stress or alleviate depression. For this reason women enter into the downward spiral further along the path to addiction, and so transition to addiction more rapidly. We propose that this sex difference is due, at least in part, to sex differences in the organization of the neural systems responsible for motivation and addiction. Additionally, we suggest that sex differences in these systems and their functioning are accentuated with addiction. In the current review we discuss historical, cultural, social and biological bases for sex differences in addiction with an emphasis on sex differences in the neurotransmitter systems that are implicated.
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1 retracted
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Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
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The Neural Basis of Addiction: A Pathology of Motivation and Choice
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Drug abuse: hedonic homeostatic dysregulation
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Cited by
Liking, wanting, and the incentive-sensitization theory of addiction
Berridge, K. C., & Robinson, T. E. (2016) · American Psychologist · doi:10.1037/amp0000059 · Cited by 1,440
Sex differences in stress-related psychiatric disorders: neurobiological perspectives
Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737
Sex Differences in Animal Models: Focus on Addiction
Becker, J. B., & Koob, G. F. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011163 · Cited by 725
Self-citationSex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513
Hunt, G. E., Large, M. M., Cleary, M., Lai, H. M. X., & Saunders, J. B. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.07.011 · Cited by 482
Metadata
- Authors
- Becker, J. B., Perry, A. N., & Westenbroek, C.
- Venue
- Biology of Sex Differences
- Published
- 2012
- Volume
- 3
- Issue
- 1
- Pages
- 14
- ISSN
- 2042-6410 (ISSN-L)
- OpenAlex
- W2115386734
- Cited by
- 317
- References
- 497
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Becker, J. B., Perry, A. N., & Westenbroek, C. (2012). Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis. Biology of Sex Differences. https://doi.org/10.1186/2042-6410-3-14
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
