Cited by 270Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerBiochemical and Molecular Research

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism

Open access

Ros, Susana, Schulze, Almut·2013·Cancer & Metabolism

DOI 10.1186/2049-3002-1-8PMC PMC4178209

Open this paper in CoChat — free account Open PDF

Abstract

The increased glucose metabolism in cancer cells is required to fulfill their high energetic and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by the activation of oncogenes or loss of tumor suppressors. They can also be part of the metabolic adaptations to the conditions imposed by the tumor microenvironment, such as the hypoxia response. Among the metabolic enzymes that are modulated by these factors are the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases (PFKFBs), a family of bifunctional enzymes that control the levels of fructose 2,6-bisphosphate (Fru-2,6-P2). This metabolite is important for the dynamic regulation of glycolytic flux by allosterically activating the rate-limiting enzyme of glycolysis phosphofructokinase-1 (PFK-1). Therapeutic strategies designed to alter the levels of this metabolite are likely to interfere with the metabolic balance of cancer cells, and could lead to a reduction in cancer cell proliferation, invasiveness and survival. This article will review our current understanding of the role of PFKFB proteins in the control of cancer metabolism and discuss the emerging interest in these enzymes as potential targets for the development of antineoplastic agents.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/2049-3002-1-8

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 PFK-2/FBPase-2 control of glycolysis and gluconeogenic pathways. Overview of glycolysis and gluconeogenesis. Enzymes: phosphofructokinase (PFK-1), fructose 1,6-bisphosphatase (FBPase), 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases (PFK-2/FBPase-2), pyruvate kinase (PK). Fructose 2,6-bisphosphate is an activator of PFK-1 and inhibitor of FBPase. Fructose 1,6-bisphosphate is an activator of PK. The rest of the enzymes and cofactors have been omitted for simplicity.CC BY · PubMed Central

Figure 2 Relative activity of 6-phosphofructo-2-kinase (PFK-2)/fructose 1,6-bisphosphatase (FBPase-2). Properties of the PFK-2/FBPase-2 enzymes. Information on chromosomal location and relative enzymatic activity of the different isoforms has been taken from Okar et al. Trends BiochemSci (2001) [7].CC BY · PubMed Central

Figure 3 Domain organizations and phosphorylation of 6-phosphofructo-2-kinase (PFK-2)/fructose 1,6-bisphosphatase (FBPase-2) isoenzymes. The N-terminal PFK-2 domain is shown in red, the C-terminal FBPase-2 domain is shown in blue and the regulatory domains are shown in green. Phosphorylation sites and the kinases responsible of their phosphorylation are indicated on each main isoforms. The domain structure of human PFK-2/FBPase-2 enzymes is based on Rider et al. Biochem J (2014) [10].CC BY · PubMed Central

Figure 4 Role of 6-phosphofructo-2-kinase (PFK-2)/fructose 1,6-bisphosphatase (FBPase)-2 in the balance between glycolytic flux and redox regulation. Glucose-6-phosphate fulfills glycolysis, glycogen synthesis and pentose phosphate pathways. The scheme shows how the PFK-2 or the FBPase-2 activity could be crucial in controlling the balance between glycolytic flux and redox regulation by the pentose phosphate pathway for nicotinamide adenine dinucleotide phosphate (NADPH) production. Enzymes: phosphofructokinase (PFK-1), phosphofructokinase 2/fructose 2,6-bisphosphatase (PFK-2/FBPase-2), TIGAR (FBPase-2 activity). Fructose 2,6-bisphosphate is an activator of PFK-1 and inhibitor of FBPase.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · cited 1×
“Adaptation to hypoxic conditions is largely mediated by HIF, a transcription factor that regulates a distinct transcriptional program [40].”
Background
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019
Cancer's Molecular Sweet Tooth and the Warburg Effect
Kim, J., & Dang, C. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1501 · Cited by 1,233
Oncogenic alterations of metabolism
Dang, C. V., & Semenza, G. L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01344-9 · Cited by 1,106
Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc
Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Wonsey, D. R., Lee, L. A., & Dang, C. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000023200 · Cited by 876
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
Marsin, A.-S., Bertrand, L., Rider, M. H., Deprez, J., Beauloye, C., Vincent, M. F., den Berghe, G. V., Carling, D., & Hue, L. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00742-9 · Cited by 853
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
Jiang, P., Du, W., Wang, X., Mancuso, A., Gao, X., Wu, M., & Yang, X. (2011) · Nature Cell Biology · doi:10.1038/ncb2172 · Cited by 834
Elevated Levels of Glucose Transport and Transporter Messenger RNA Are Induced by ras or src Oncogenes
Flier, J. S., Mueckler, M., Usher, P., & Lodish, H. F. (1987) · Science · doi:10.1126/science.3103217 · Cited by 783
Glucose utilization of cerebral gliomas measured by [ 18 F] fluorodeoxyglucose and positron emission tomography
Chiro, G. D., DeLaPaz, R. L., Brooks, R. A., Sokoloff, L., Kornblith, P. L., Smith, B. H., Patronas, N. J., Kufta, C. V., KESSLER, R. M., Johnston, G. S., et al. (1982) · Neurology · doi:10.1212/wnl.32.12.1323 · Cited by 746
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
Massie, C. E., Lynch, A., Ramos‐Montoya, A., Boren, J., Stark, R., Fazli, L., Warren, A., Scott, H., Madhu, B., Sharma, N., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.158 · Cited by 624
Metabolic profiles of human brain tumors using quantitative in vivo 1 H magnetic resonance spectroscopy
Howe, F. A., Barton, S. J., Cudlip, S., Stubbs, M., Saunders, D. E., Murphy, M., Wilkins, P. R., Opstad, K. S., Doyle, V. L., McLean, M. A., et al. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10367 · Cited by 535
Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades
Deprez, J., Vertommen, D., Alessi, D. R., Hue, L., & Rider, M. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17269 · Cited by 462
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis
Rider, M. H., Bertrand, L., Vertommen, D., Michels, P. A. M., Rousseau, G. G., & Hue, L. (2004) · Biochemical Journal · doi:10.1042/bj20040752 · Cited by 435
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
Clem, B. F., Telang, S., Clem, A. L., Yalçın, A., Meier, J. B., Simmons, A. J., Rasku, M. A., Arumugam, S., Dean, W. L., Eaton, J. W., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0482 · Cited by 430
Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer
Yalçın, A., Telang, S., Clem, B. F., & Chesney, J. A. (2009) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2009.01.003 · Cited by 407
Biological consequences of tumor hypoxia
ckel, M. H., & Vaupel, P. W. (2001) · Seminars in Oncology · doi:10.1016/s0093-7754(01)90211-8 · Cited by 384
Systemic elevation of PTEN induces a tumor-suppressive metabolic state
Garcia-Cao, I., Song, M. S., Hobbs, R. M., Laurent, G., Giorgi, C., de Boer, V. C. J., Anastasiou, D., Ito, K., Sasaki, A. T., Rameh, L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.030 · Cited by 377
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
García-Higuera, I., Manchado, E., Dubus, P. R., Cañamero, M., Méndez, J., Moreno, S., & Malumbres, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1742 · Cited by 357
PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate
Okar, D. A., Lange, A. J., Manzano, À., Navarro‐Sabaté, À., Riera, L., & Bartrons, R. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01699-6 · Cited by 356
Fructose 2,6‐Bisphosphate
SCHAFTINGEN, E. V. (1987) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470123058.ch7 · Cited by 333
High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.
Atsumi, T., Chesney, J. A., Metz, C. N., Leng, L., Donnelly, S. C., Makita, Z., Mitchell, R., & Bucala, R. (2002) · PubMed · Cited by 322
An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: Role in tumor cell glycolysis and the Warburg effect
Chesney, J. A., Mitchell, R., Benigni, F., Bacher, M., Spiegel, L. A., Al‐Abed, Y., Han, J. H., Metz, C. N., & Bucala, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3047 · Cited by 284
6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE: A METABOLIC SIGNALING ENZYME
Pilkis, S. J., Claus, T. H., Kurland, I. J., & Lange, A. J. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.004055 · Cited by 278
6-Phosphofructo-2-kinase (pfkfb3) Gene Promoter Contains Hypoxia-inducible Factor-1 Binding Sites Necessary for Transactivation in Response to Hypoxia
Obach, M., Navarro‐Sabaté, À., Caro, J., Kong, X., Duran, J., Gómez, M., Perales, J. C., Ventura, F., Rosa, J. L., & Bartrons, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406096200 · Cited by 274
SnapShot: Reactive Oxygen Intermediates (ROI)
Nathan, C., & Ding, A. H. (2010) · Cell · doi:10.1016/j.cell.2010.03.008 · Cited by 248
Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (pfkfb-1-4) expression in vivo
Minchenko, O., Opentanova, I., & Caro, J. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01179-7 · Cited by 236
Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer
Bando, H., Atsumi, T., Nishio, T., Niwa, H., Mishima, S., Shimizu, C., Yoshioka, N., Bucala, R., & Koike, T. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0149 · Cited by 208
Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival
R�os, S., Santos, C. R., Moco, S., Baenke, F., Kelly, G. P., Howell, M. T., Zamboni, N., & Schulze, A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0234 · Cited by 201
Self-citation
The effect of natural and synthetic D-fructose 2,6-bisphosphate on the regulatory kinetic properties of liver and muscle phosphofructokinases.
Uyeda, K., Furuya, E., & Luby, L. J. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68856-3 · Cited by 195
Fructose‐2,6‐bisphosphate and control of carbohydrate metabolism in eukaryotes
Okar, D. A., & Lange, A. J. (1999) · BioFactors · doi:10.1002/biof.5520100101 · Cited by 178
Ras transformation requires metabolic control by 6-phosphofructo-2-kinase
Telang, S., Yalçın, A., Clem, A. L., Bucala, R., Lane, A. N., Eaton, J. W., & Chesney, J. A. (2006) · Oncogene · doi:10.1038/sj.onc.1209709 · Cited by 166
E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation
Almeida, A., Bolaños, J. P., & Moncada, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913668107 · Cited by 166
Mechanisms of control of heart glycolysis
Depré, C., Rider, M. H., & Hue, L. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2580277.x · Cited by 164
RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival
Goidts, V., Bageritz, J., Puccio, L., Nakata, S., Zapatka, M., Barbus, S., Toedt, G., Campos, B., Korshunov, A., Momma, S., et al. (2011) · Oncogene · doi:10.1038/onc.2011.490 · Cited by 150
Fructose‐2,6‐bisphosphatase from Rat Liver
SCHAFTINGEN, E. V., Davies, D. R., & Hers, H. G. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb05917.x · Cited by 146
Hormonal control of fructose 2,6-bisphosphate concentration in isolated rat hepatocytes
Bartrons, R., Hue, L., SCHAFTINGEN, E. V., & Hers, H. G. (1983) · Biochemical Journal · doi:10.1042/bj2140829 · Cited by 146
Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells
Moon, J.-S., Jin, W.-J., Kwak, J.-H., Kim, H.-J., Yun, M.-J., KIM, J.-W., Park, S. W., & Kim, K.-S. (2011) · Biochemical Journal · doi:10.1042/bj20101104 · Cited by 125
PFKFB3 gene silencing decreases glycolysis, induces cell‐cycle delay and inhibits anchorage‐independent growth in HeLa cells
Calvo, M., Bartrons, R., Castaño, E., Perales, J. C., Navarro‐Sabaté, À., & Manzano, À. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.093 · Cited by 124
Hypoxia induces transcription of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase‐4 gene via hypoxia‐inducible factor‐1α activation
Minchenko, О. H., Opentanova, I. L., Minchenko, D. O., Ogura, T., & Esumi, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.053 · Cited by 121
Molecular cloning of the DNA and expression and characterization of rat testes fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
Sakata, J., Abe, Y., & Uyeda, K. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98475-9 · Cited by 104
Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors
Minchenko, О. H., Ochiai, A., Opentanova, I., Ogura, T., Minchenko, D. O., Caro, J., Комісаренко, С. В., & Esumi, H. (2005) · Biochimie · doi:10.1016/j.biochi.2005.04.007 · Cited by 102
Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.
Bobarykina, A. Y., Minchenko, D. O., Opentanova, I. L., Moenner, M., Caro, J., Esumi, H., & Minchenko, О. H. (2006) · Acta Biochimica Polonica · doi:10.18388/abp.2006_3308 · Cited by 96
Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: Beyond its allosteric effects on glycolytic and gluconeogenic enzymes
Wu, C., Khan, S. A., Peng, L.-J., & Lange, A. J. (2006) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2006.01.010 · Cited by 82
Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect
Seo, M., Kim, J., Neau, D. B., Sehgal, I., & Lee, Y. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024179 · Cited by 80
Heart 6-Phosphofructo-2-kinase Activation by Insulin Results from Ser-466 and Ser-483 Phosphorylation and Requires 3-Phosphoinositide-dependent Kinase-1, but Not Protein Kinase B
Bertrand, L., Alessi, D. R., Deprez, J., Deák, M., Viaene, E., Rider, M. H., & Hue, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30927 · Cited by 72
Phosphorylation of myocardial fructose-6-phosphate,2-kinase: fructose-2,6-bisphosphatase by cAMP-dependent protein kinase and protein kinase C. Activation by phosphorylation and amino acid sequences of the phosphorylation sites.
Kitamura, K., Kangawa, K., Matsuo, H., & Uyeda, K. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37461-1 · Cited by 68
Cloning of cDNA Encoding for a Novel Isozyme of Fructose 6-Phosphate,2-Kinase/Fructose 2,6-Bisphosphatase from Human Placenta
Sakai, A., Kato, M., Fukasawa, M., Ishiguro, M., Furuya, E., & Sakakibara, R. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021270 · Cited by 61
Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain
Keßler, R., & Eschrich, K. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00014-6 · Cited by 53
Overexpression of murine fizzy-related (fzr) increases natural killer cell–mediated cell death and suppresses tumor growth
Wang, C.-X., Fisk, B. C., Wadehra, M., Su, H. C., & Braun, J. G. (2000) · Blood · doi:10.1182/blood.v96.1.259 · Cited by 51
Characterization of a hepatoma mRNA transcribed from a third promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-encoding gene and controlled by ets oncogene-related products.
Dupriez, V. J., Darville, M. I., Antoine, I. V., Gégonne, A., Ghysdael, J., & Rousseau, G. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8224 · Cited by 49
The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure
Navarro‐Sabaté, À., Manzano, À., Riera, L., Rosa, J. L., Ventura, F., & Bartrons, R. (2001) · Gene · doi:10.1016/s0378-1119(00)00591-6 · Cited by 42
Fructose 2,6-bisphosphate metabolism in Ehrlich ascites tumour cells
Nissler, K., Petermann, H., Wenz, I., & Brox, D. H. (1995) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01213320 · Cited by 41
Sequence and structure of the human 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase heart isoform gene (PFKFB2)
Heine‐Suñer, D., Díaz‐Guillén, M. A., Lange, A. J., & de Córdoba, S. R. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2540103.x · Cited by 41
A Common Phosphorylation Site for Cyclic AMP-dependent Protein Kinase and Protein Kinase C in Human Placental 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase
Okamura, N., & Sakakibara, R. (1998) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.62.2039 · Cited by 38
Effect of glutamine on fructose 2,6-bisphosphate and on glucose metabolism in HeLa cells and in chick-embryo fibroblasts
Mojena, M., Boscá, L., & Hue, L. (1985) · Biochemical Journal · doi:10.1042/bj2320521 · Cited by 36
Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.
Minchenko, O. H., Opentanova, I. L., Ogura, T., Minchenko, D. O., Комісаренко, С. В., Caro, J., & Esumi, H. (2005) · Acta Biochimica Polonica · doi:10.18388/abp.2005_3402 · Cited by 34
Evidence for new phosphorylation sites for protein kinase C and cyclic AMP‐dependent protein kinase in bovine heart 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase
Rider, M. H., Damme, J. V., Vertommen, D., Michel, A., Vandekerckhove, J. S., & Hue, L. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81315-d · Cited by 30
Reactive Oxygen Species-independent Oxidation of Thioredoxin in Hypoxia
Muniyappa, H., Song, S., Mathews, C. K., & Das, K. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008557 · Cited by 28
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family overexpression in human lung tumor.
Minchenko, О. H., Ogura, T., Opentanova, I., Minchenko, D. O., Ochiai, A., Caro, J., Комісаренко, С. В., & Esumi, H. (2005) · PubMed · Cited by 28
Cloning and Expression of a Catalytic Core Bovine Brain 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase
Ventura, F., Ambrosio, S., Bartrons, R., El‐Maghrabi, M. R., Lange, A., & Pilkis, S. J. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1616 · Cited by 27
The impairment of respiration by glycolysis in the Lewis lung carcinoma
Miralpeix, M., Azcón‐Bieto, J., Bartrons, R., & Argilés, J. M. A. (1990) · Cancer Letters · doi:10.1016/0304-3835(90)90261-u · Cited by 23
Characterization of an enhancer upstream from the muscle-type promoter of a gene encoding 6–phosphofructo–2–kinase/fructose–2, 6–bisphosphatase
Darville, M. I., Antoine, I. V., & Rousseau, G. G. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.14.3575 · Cited by 23
LOH on 10p14‐p15 targets the PFKFB3 gene locus in human glioblastomas
Fleischer, M., Keßler, R., Klammer, A., Warnke, J., & Eschrich, K. (2011) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20914 · Cited by 20
Inhibition of Tumor Cell Growth by A Specific 6-Phosphofructo-2-kinase Inhibitor,N-Bromoacetylethanolamine Phosphate, and Its Analogues
HIRATA, T., Watanabe, M., MIURA, S., Ijichi, K., Fukasawa, M., & Sakakibara, R. (2000) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.64.2047 · Cited by 20
Rat gene coding for heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: characterization of an unusual promoter region and identification of four mRNAs
Chikri, M., & Rousseau, G. (1995) · Biochemistry · doi:10.1021/bi00027a040 · Cited by 13
Control of the fructose 6-phosphate/fructose 2,6-bisphosphate cycle by sn-glycerol 3-phosphate.
Frenzel, J., Schellenberger, W., Eschrich, K., & Hofmann, E. (1988) · PubMed · Cited by 9
Alternative splice variants of rat 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase-4 mRNA.
Minchenko, D. O., Mykhalchenko, V. G., Tsuchihara, K., Kanehara, S., Yavorovsky, O. P., Zavgorodny, I. V., Paustovskyi, Y. O., Комісаренко, С. В., Esumi, H., & Minchenko, О. H. (2008) · PubMed · Cited by 5

Sorted by citations

Metformin—mode of action and clinical implications for diabetes and cancer
Pernicova, I., & Korbonits, M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.256 · Cited by 1,393
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
Hay, N. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.77 · Cited by 1,152
Tumor glycolysis, an essential sweet tooth of tumor cells
Paul, S., Ghosh, S., & Kumar, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.09.007 · Cited by 449
Four Key Steps Control Glycolytic Flux in Mammalian Cells
Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E., & Rabinowitz, J. D. (2018) · Cell Systems · doi:10.1016/j.cels.2018.06.003 · Cited by 383
Endothelial PFKFB3 Plays a Critical Role in Angiogenesis
Xu, Y., An, X., Guo, X., Habtetsion, T. G., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.303041 · Cited by 256

See all 270

Authors: Ros, S., & Schulze, A.
Affiliations: Cancer Research UK (GB)
Corresponding author: Schulze, Almut
ORCID: Schulze, Almut
Venue: Cancer & Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2013-02-04
Volume: 1
Issue: 1
Pages: 8-8
ISSN: 2049-3002 (ISSN-L)
DOI: 10.1186/2049-3002-1-8
PMC: PMC4178209
OpenAlex: W2106223802
Cited by: 269
References: 69
Citations by year: 2026: 9 · 2025: 21 · 2024: 29 · 2023: 32 · 2022: 31 · 2021: 26 · 2020: 15 · 2019: 20 · 2018: 17 · 2017: 17 · 2016: 19 · 2015: 20 · 2014: 11 · 2013: 2
FWCI: 6.22
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/2.0 (tdm)
Locations: Cancer & Metabolism (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Apollo (University of Cambridge) (submittedVersion, cc-by)
Apollo (cc-by)
Funders: Cancer Research UK
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, fructose-2,6-bisphosphate, glycolytic flux, tumor microenvironment, hypoxia response, oncogene activation, tumor suppressor loss

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks