Herpes simplex encephalitis in Iceland 1987–2011
Open accessAbstract
Herpes simplex encephalitis (HSE) is a serious disease with 10-20% mortality and high rate of neuropsychiatric sequelae. This study is a long-term, nationwide study in a single country, Iceland. Clinical data were obtained from patient records and from DNA PCR and antibody assays of CSF. Diagnosis of HSE was classified as definite, possible or rejected based on symptoms, as well as virological, laboratory and brain imaging criteria. A total of 30 definite cases of HSE were identified during the 25 year period 1987-2011 corresponding to incidence of 4.3 cases/106 inhabitants/year. Males were 57% of all patients, median age 50 years (range, 0-85). Fever (97%), cognitive deficits (79%), impaired consciousness (79% with GCS < 13), headache (55%) and seizures (55%) were the most common symptoms. Brain lesions were found in 24 patients (80%) by MRI or CT. All patients received intravenous acyclovir for a mean duration of 20 days. Three patients (10%) died within one year and 21/28 pts (75%) had a Karnofsky performance score of <70% with memory loss (59%), dysphasia (44%), frontal symptoms (44%) and seizures (30%) as the most frequent sequelae. Mean delay from onset of symptoms to treatment was 6 days; this was associated with adverse outcome. In conclusion, the incidence of `HSE is higher than recently reported in a national registry study from Sweden. Despite advances in rapid diagnosis and availability of treatment of HSE, approximately three of every four patients die or are left with serious neurological impairment.
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ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS
Teasdale, G., & Jennett, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91639-0 · Cited by 13,215 · see citing works
Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis
Li, J. S., Sexton, D. J., Mick, N., Nettles, R., Fowler, V. G., Ryan, T., Bashore, T., & Corey, G. R. (2000) · Clinical Infectious Diseases · doi:10.1086/313753 · Cited by 4,027 · see citing works
Karnofsky, D. A., Abelmann, W. H., Craver, L. F., & Burchenal, J. H. (1948) · Cancer · doi:10.1002/1097-0142(194811)1:4 · Cited by 2,249 · see citing works
Granerod, J., Ambrose, H. E., Davies, N. W., Clewley, J. P., Walsh, A. L., Morgan, D., Cunningham, R., Zuckerman, M., Mutton, K. J., Solomon, T., et al. (2010) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(10)70222-x · Cited by 1,358 · see citing works
Vidarabine versus Acyclovir Therapy in Herpes Simplex Encephalitis
Whitley, R. J., Alford, C. A., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J., Soong, S.-J., & The NIAID Collaborative Antiviral Study Group* (1986) · New England Journal of Medicine · doi:10.1056/nejm198601163140303 · Cited by 896 · see citing works
Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis
Whitley, R. J., Soong, S., Dolin, R., Galasso, G. J., Chʼien, L. T., Alford, C. A., & the Collaborative Study Group (1977) · New England Journal of Medicine · doi:10.1056/nejm197708112970601 · Cited by 713 · see citing works
Lakeman, F. D., & Whitley, R. J. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.4.857 · Cited by 662 · see citing works
ACYCLOVIR VERSUS VIDARABINE IN HERPES SIMPLEX ENCEPHALITIS
Sköldenberg, B., Alestig, K., Burman, L., Forkman, A., Lövgren, K., Norrby, R., Stiernstedt, G., Forsgren, M., Bergström, T., Dahlqvist, E., et al. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92623-0 · Cited by 610 · see citing works
Aurelius, E., Johansson, B., Staland, Å., Forsgren, M., Aurelius, E., & Sköldenberg, B. (1991) · The Lancet · doi:10.1016/0140-6736(91)92155-u · Cited by 545 · see citing works
Raschilas, F., Wolff, M., Delatour, F., Chaffaut, C., de Broucker, T., Chevret, S., Lebon, P., Canton, P., & Rozenberg, F. (2002) · Clinical Infectious Diseases · doi:10.1086/341405 · Cited by 524 · see citing works
Glaser, C. A., Gilliam, S., Schnurr, D. P., Forghani, B., Honarmand, S., Khetsuriani, N., Fischer, M., Cossen, C. K., & Anderson, L. J. (2003) · Clinical Infectious Diseases · doi:10.1086/367841 · Cited by 431 · see citing works
Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome
Mcgrath, N., Anderson, N. E., Croxson, M., & Powell, K. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.3.321 · Cited by 425 · see citing works
Herpes Simplex Encephalitis: Clinical Assessment
Whitley, R. J., Soong, S., Linneman, C., Liu, C., Pazin, G., & Alford, C. A. (1982) · JAMA · doi:10.1001/jama.1982.03320280037026 · Cited by 337 · see citing works
Herpes simplex encephalitis in Sweden, 1990-2001: incidence, morbidity, and mortality.
Hjalmarsson, A., Blomqvist, P., & Sköldenberg, B. (2007) · Clinical Infectious Diseases · doi:10.1086/521262 · Cited by 267 · see citing works
Weil, A. A., Glaser, C. A., Amad, Z., & Forghani, B. (2002) · Clinical Infectious Diseases · doi:10.1086/339550 · Cited by 254 · see citing works
Aurelius, E., Johansson, B., Sköldenberg, B., & Forsgren, M. (1993) · Journal of Medical Virology · doi:10.1002/jmv.1890390302 · Cited by 249 · see citing works
Cinque, P. M., Vago, L., Dahl, H., et al. (1996) · AIDS · doi:10.1097/00002030-199610090-00004 · Cited by 200 · see citing works
Mailles, A., De Broucker, T., Costanzo, P., Martinez-Almoyna, L., Vaillant, V., Stahl, J.-P., & on behalf of the Steering Committee and Investigators Group (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis226 · Cited by 161 · see citing works
Domingues, R. B., Fink, M. C. D., Tsanaclis, A. M. C., et al. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00069-0 · Cited by 143 · see citing works
Herpes simplex encephalitis and management of acyclovir in encephalitis patients in France
Stahl, J. ‐., Mailles, A., & de Broucker, T. (2011) · Epidemiology and Infection · doi:10.1017/s0950268811000483 · Cited by 95 · see citing works
Advantage of magnetic resonance imaging in the diagnosis of cerebral infections
Schroth, G., Kretzschmar, K., Gawehn, J., et al. (1987) · Neuroradiology · doi:10.1007/bf00327535 · Cited by 95 · see citing works
Puchhammer‐Stöckl, E., Presterl, E., Croÿ, C., Aberle, S. W., Popow‐Kraupp, T., Kundi, M., Hofmann, H., Wenninger, U., & Gödl, I. (2001) · Journal of Medical Virology · doi:10.1002/jmv.1082 · Cited by 81 · see citing works
Polymerase chain reaction for diagnosis of genital herpes in a genitourinary medicine clinic
Scoular, A. (2002) · Sexually Transmitted Infections · doi:10.1136/sti.78.1.21 · Cited by 80 · see citing works
Jacobi, C., Lange, P., & Reiber, H. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.04.002 · Cited by 80 · see citing works
Trend of hospital utilization for encephalitis
Barbadoro, P., Marigliano, A. L., Ricciardi, A., et al. (2011) · Epidemiology and Infection · doi:10.1017/s0950268811001002 · Cited by 38 · see citing works
Banatvala, J. E. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70012-3 · Cited by 21 · see citing works
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Ramakrishna, C., Kujawski, M., Chu, H., Li, L., Mazmanian, S. K., & Cantin, E. M. (2019) · Nature Communications · doi:10.1038/s41467-019-09884-6 · Cited by 284 · see citing works
Damiano, R. F., Guedes, B. F., de Rocca, C. C., de Pádua Serafim, A., Castro, L. H. M., Munhoz, C. D., Nitrini, R., Filho, G. B., Miguel, E. C., Lucchetti, G., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01286-4 · Cited by 98 · see citing works
Erdem, H., Cag, Y., Ozturk-Engin, D., Defres, S., Kaya, S., Larsen, L., Poljak, M., Barsic, B., Argemi, X., Sørensen, S. M., et al. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05016-14 · Cited by 74 · see citing works
Hansen, A.-B. E., Vestergaard, H., Dessau, R. B., Bodilsen, J., Andersen, N. S., Omland, L. H., Christiansen, C. B., Ellermann-Eriksen, S., Nielsen, L., Benfield, T., et al. (2020) · Clinical Epidemiology · doi:10.2147/clep.s256838 · Cited by 27 · see citing works
- Authors
- Dagsdóttir, H. M., Sigurðardóttir, B., Gottfreðsson, M., Kristjánsson, M., Löve, A., Baldvinsdóttir, G. E., & Guðmundsson, S.
- Affiliations
- University of Iceland (IS)
- National University Hospital of Iceland (IS)
- Venue
- SpringerPlus
- Published
- 2014-09-13
- Volume
- 3
- Issue
- 1
- Pages
- 524-524
- ISSN
- 2193-1801 (ISSN-L)
- PMC
- PMC4174550
- OpenAlex
- W2125469424
- Cited by
- 35
- References
- 26
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 3
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- SpringerPlus (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Keywords
- herpes simplex encephalitis, incidence, clinical features, neuropsychiatric sequelae, mortality, acyclovir therapy, diagnostic criteria, cerebrospinal fluid PCR, Karnofsky performance status, treatment delay, Iceland
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