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Cited by 401

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Developments in the scientific understanding of osteoarthritis

Open access
Abramson, Steven B, Attur, Mukundan·2009·Arthritis Research & Therapy
DOI 10.1186/ar2655
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Abstract

Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a variety of risk factors--such as advancing age, obesity, and trauma--that conspire to incite a cascade of pathophysiologic events within joint tissues. An important emerging theme in osteoarthritis is a broadening of focus from a disease of cartilage to one of the 'whole joint'. The synovium, bone, and cartilage are each involved in pathologic processes that lead to progressive joint degeneration. Additional themes that have emerged over the past decade are novel mechanisms of cartilage degradation and repair, the relationship between biomechanics and biochemical pathways, the importance of inflammation, and the role played by genetics. In this review we summarize current scientific understanding of osteoarthritis and examine the pathobiologic mechanisms that contribute to progressive disease.

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Metadata

Authors
Abramson, S. B., & Attur, M.
Venue
Arthritis Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2009
Volume
11
Issue
3
Pages
227
ISSN
1478-6354 (ISSN-L)
DOI
10.1186/ar2655
OpenAlex
W2129531706
Cited by
401
References
72
FWCI
20.93
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.