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Cited by 333

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

Open access
Chabaud, Martine, Lubberts, Erik, Joosten, Leo, van den Berg, Wim, Miossec, Pierre·2001·Arthritis Research & Therapy
DOI 10.1186/ar294
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Abstract

The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human RA bone explants, IL-17 also increased bone resorption and decreased formation. Addition of IL-1 in these conditions increased the effect of IL-17. Blocking of bone-derived endogenous IL-17 with specific inhibitors resulted in a protective inhibition of bone destruction. Conversely, intra-articular administration of IL-17 into a normal mouse joint induced cartilage degradation. In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA.

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Metadata

Authors
Chabaud, M., Lubberts, E., Joosten, L., van den Berg, W., & Miossec, P.
Venue
Arthritis Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2001-01-26
Volume
3
Issue
3
Pages
168-77
ISSN
  • 1478-6354 (ISSN-L)
  • 1478-6362
DOI
10.1186/ar294
OpenAlex
W1856119395
Cited by
333
References
42
FWCI
11.02
Type
journal article
Language
en
Open access
gold

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