Increased expression of interleukin 17 in inflammatory bowel disease
Open accessAbstract
Background and aim: Interleukin (IL) 17 is a cytokine which exerts strong proinflammatory activities. In this study we evaluated changes in IL-17 expression in the inflamed mucosa and in the serum of patients with inflammatory bowel disease (IBD). Methods: Tissue samples were obtained endoscopically or surgically from patients with ulcerative colitis (UC) (n=20), Crohn’s disease (CD) (n=20), infectious colitis (n=5), ischaemic colitis (n=8), and normal colorectal tissues (n=15). IL-17 expression was evaluated by a standard immunohistochemical procedure. Serum IL-17 levels were determined by ELISA. IL-17 mRNA expression was analysed by reverse transcriptase-polymerase chain reaction. Results: IL-17 expression was not detected in samples from normal colonic mucosa, infectious colitis, or ischaemic colitis. In the inflamed mucosa of active UC and CD patients, IL-17 expression was clearly detectable in CD3 + T cells or CD68 + monocytes/macrophages. The average number of IL-17 + cells was significantly increased in active UC and CD patients compared with inactive patients. IL-17 mRNA expression was not detected in normal mucosa but was detectable in the mucosa from active UC and CD patients. IL-17 was not detected in the sera from normal individuals, infectious colitis, or ischaemic colitis patients but IL-17 levels were significantly elevated in IBD patients. Conclusions: IL-17 expression in the mucosa and serum was increased in IBD patients. It is likely that IL-17 expression in IBD may be associated with altered immune and inflammatory responses in the intestinal mucosa.
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In experimental models of psoriasis, Th17 cells are considered the main pathogenic T cell population driving disease.
“In experimental models of psoriasis, Th17 cells are thought to be the main pathogenic T cell population driving disease.”
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- Authors
- Fujino, S., Andoh, A., Bamba, S., Ogawa, A., Hata, K., Araki, Y., Bamba, T., & Fujiyama, Y.
- Affiliations
- Shiga University of Medical Science (JP)
- Corresponding author
- Andoh, A
- ORCID
- Bamba, S
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2003-01
- Volume
- 52
- Issue
- 1
- Pages
- 65-70
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1773503
- OpenAlex
- W2126874760
- Cited by
- 1,713
- References
- 49
- Citations by year
- 2026: 26 · 2025: 61 · 2024: 57 · 2023: 61 · 2022: 75 · 2021: 74 · 2020: 71 · 2019: 72 · 2018: 78 · 2017: 82 · 2016: 90 · 2015: 79 · 2014: 105 · 2013: 124 · 2012: 110
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (13470119, 12470121)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- IL-17, inflammatory bowel disease, ulcerative colitis, Crohn's disease, intestinal mucosa inflammation, CD3+ T cells, CD68+ macrophages, infectious colitis, ischemic colitis, inflammatory cytokines
- MeSH terms
- Acute Disease, Colitis, Colitis, Ulcerative, Crohn Disease, Humans, Immunohistochemistry, Intestinal Mucosa, Macrophages, Monocytes, RNA, Messenger, T-Lymphocytes, Inflammatory Bowel Diseases, Case-Control Studies, Colitis, Ischemic, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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