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The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia
Open accessAbstract
Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have also noted alterations in central pain processing in osteoarthritis, and some data, including the observation of widespread pain sensitivity, suggest that central pain-processing defects may alter the pain response in rheumatoid arthritis patients. When central pain is identified, different classes of analgesics (for example, serotonin-norepinephrine reuptake inhibitors, α2δ ligands) may be more effective than drugs that treat peripheral or nociceptive pain (for example, nonsteroidal anti-inflammatory drugs and opioids).
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“Poor sleep is related to a disturbance of central painprocessing mechanisms, identified as a”
From Efficacy of Combined Cognitive-Behavioral Therapy for Insomnia and Pain in Patients with Fibromyalgia: A Randomized Controlled Trial (2018) · cites this paper as Lee et al. 2011
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Metadata
- Authors
- Lee, Y. C., Nassikas, N. J., & Clauw, D. J.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Michigan (US)
- Corresponding author
- Lee, Yvonne C
- Venue
- Arthritis Research & Therapy
- Published
- 2011
- Volume
- 13
- Issue
- 2
- Pages
- 211
- ISSN
- 1478-6354 (ISSN-L)
- PMC
- PMC3132050
- OpenAlex
- W2140037651
- Cited by
- 377
- References
- 87
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 21 · 2023: 28 · 2022: 18 · 2021: 38 · 2020: 28 · 2019: 31 · 2018: 30 · 2017: 25 · 2016: 24 · 2015: 24 · 2014: 27 · 2013: 29 · 2012: 23
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Arthritis Research & Therapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 057578, K23AR057578)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- chronic pain, central nervous system, rheumatoid arthritis, osteoarthritis, fibromyalgia, central sensitization, widespread pain, pain processing, serotonin-norepinephrine reuptake inhibitors, gabapentinoids, analgesic efficacy
- MeSH terms
- Animals, Arthritis, Rheumatoid, Central Nervous System, Fibromyalgia, Humans, Osteoarthritis, Chronic Pain
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