Cited by 377Pain Mechanisms and TreatmentsMusculoskeletal pain and rehabilitationFibromyalgia and Chronic Fatigue Syndrome Research

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Open access

Lee, Yvonne C, Nassikas, Nicholas J, Clauw, Daniel J·2011·Arthritis Research & Therapy

DOI 10.1186/ar3306PMC PMC3132050

Open this paper in CoChat — free account

Abstract

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have also noted alterations in central pain processing in osteoarthritis, and some data, including the observation of widespread pain sensitivity, suggest that central pain-processing defects may alter the pain response in rheumatoid arthritis patients. When central pain is identified, different classes of analgesics (for example, serotonin-norepinephrine reuptake inhibitors, α2δ ligands) may be more effective than drugs that treat peripheral or nociceptive pain (for example, nonsteroidal anti-inflammatory drugs and opioids).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/ar3306

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II
Lawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H. K., Deyo, R. A., Gabriel, S. E., Hirsch, R., Hochberg, M. C., Hunder, G. G., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23176 · Cited by 5,599
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929
Descending control of pain
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gracely, R. H., Petzke, F., Wolf, J. M., & Clauw, D. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10225 · Cited by 1,263
Self-citation
Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management
Woolf, C. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-8-200404200-00010 · Cited by 1,134
Sensitization in patients with painful knee osteoarthritis
Arendt‐Nielsen, L., Nie, H., Laursen, M. B., Laursen, B. S., Madeleine, P., Simonsen, O. H., & Graven‐Nielsen, T. (2010) · Pain · doi:10.1016/j.pain.2010.04.003 · Cited by 992
The discordance between clinical and radiographic knee osteoarthritis: A systematic search and summary of the literature
Bedson, J., & Croft, P. R. (2008) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-9-116 · Cited by 951
Evidence of augmented central pain processing in idiopathic chronic low back pain
Giesecke, T., Gracely, R. H., Grant, M. A. B., NACHEMSON, A. L., Petzke, F. W., Williams, D. A., & Clauw, D. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20063 · Cited by 818
Self-citation
Pregabalin for acute and chronic pain in adults
Moore, R. A., Straube, S., Wiffen, P. J., Derry, S., & McQuay, H. J. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007076.pub2 · Cited by 786
Pregabalin for the treatment of fibromyalgia syndrome: Results of a randomized, double‐blind, placebo‐controlled trial
Crofford, L. J., Rowbotham, M. C., Mease, P. J., Russell, I. J., Dworkin, R. H., Corbin, A. E., Young, J. P., LaMoreaux, L., Martin, S. A., Sharma, U., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20983 · Cited by 652
Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity
Napadow, V., LaCount, L., Park, K., As‐Sanie, S., Clauw, D. J., & Harris, R. E. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27497 · Cited by 645
Self-citation
Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition
Julien, N., Goffaux, P., Arsenault, P., & Marchand, S. (2005) · Pain · doi:10.1016/j.pain.2004.12.032 · Cited by 634
A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder
Arnold, L. M., Lu, Y., Crofford, L. J., Wohlreich, M., Detke, M. J., Iyengar, S., & Goldstein, D. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20485 · Cited by 624
Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis
Russell, I. J., Værøy, H., Javors, M. A., & Nyberg, F. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350509 · Cited by 546
Possible Deficiencies of Pain Modulation in Fibromyalgia
Lautenbacher, S., & Rollman, G. B. (1997) · Clinical Journal of Pain · doi:10.1097/00002508-199709000-00003 · Cited by 546
The effects of sleep deprivation on pain inhibition and spontaneous pain in women
Smith, M. T., Edwards, R. R., McCann, U. D., & Haythornthwaite, J. A. (2007) · Sleep · doi:10.1093/sleep/30.4.494 · Cited by 539
Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects
Kosek, E., & Hansson, P. T. (1997) · Pain · doi:10.1016/s0304-3959(96)03295-2 · Cited by 539
Decreased Central μ-Opioid Receptor Availability in Fibromyalgia
Harris, R. E., Clauw, D. J., Scott, D., McLean, S. A., Gracely, R. H., & Zubieta, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2849-07.2007 · Cited by 525
Self-citation
Mechanisms of Pain in Arthritis
Schaible, H., Ebersberger, A., & von Banchet, G. S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04234.x · Cited by 515
Descending control of persistent pain: inhibitory or facilitatory?
Vanegas, H., & Schaible, H. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.004 · Cited by 510
Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief
Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476
A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder
Arnold, L. M., Rosen, A., Pritchett, Y. L., D'Souza, D. N., Goldstein, D. J., Iyengar, S., & Wernicke, J. F. (2005) · Pain · doi:10.1016/j.pain.2005.06.031 · Cited by 471
The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans
Pud, D., Granovsky, Y., & Yarnitsky, D. (2009) · Pain · doi:10.1016/j.pain.2009.02.015 · Cited by 465
Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies
Neogi, T., Felson, D. T., Niu, J., Nevitt, M. C., Lewis, C. E., Aliabadi, P., Sack, B., Torner, J. C., Bradley, L. A., & Zhang, Y. (2009) · BMJ · doi:10.1136/bmj.b2844 · Cited by 460
Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients
Gwilym, S. E., Keltner, J. R., Warnaby, C. E., Carr, A. J., Chizh, B. A., Chessell, I. P., & Tracey, I. (2009) · Arthritis Care & Research · doi:10.1002/art.24837 · Cited by 431
Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
Graven‐Nielsen, T., Kendall, S. A., Henriksson, K. G., Bengtsson, M., Sörensen, J., Johnson, A. F., Gerdle, B. U. C., & Arendt‐Nielsen, L. (2000) · Pain · doi:10.1016/s0304-3959(99)00308-5 · Cited by 417
Functional imaging of pain in patients with primary fibromyalgia.
Cook, D. B., Lange, G., Ciccone, D. S., Liu, W., Steffener, J., & Natelson, B. H. (2004) · PubMed · Cited by 393
Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome
Staud, R. M., Cannon, R. L., Mauderli, A. P., Robinson, M. E., Price, D. D., & Vierck, C. J. (2003) · Pain · doi:10.1016/s0304-3959(02)00344-5 · Cited by 379
Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients
Price, D. D., Staud, R. M., Robinson, M. E., Mauderli, A. P., Cannon, R. L., & Vierck, C. J. (2002) · Pain · doi:10.1016/s0304-3959(02)00053-2 · Cited by 374
Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial ☆
Russell, J. I., Mease, P. J., Smith, T. R., Kajdasz, D. K., Wohlreich, M. M., Detke, M. J., Walker, D. J., Chappell, A. S., & Arnold, L. M. (2008) · Pain · doi:10.1016/j.pain.2008.02.024 · Cited by 367
Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain
Jensen, K. B., Kosek, E., Petzke, F., Carville, S., Fransson, P., Marcus, H., Williams, S. C. R., Choy, E., Giesecke, T., Mainguy, Y., et al. (2009) · Pain · doi:10.1016/j.pain.2009.03.018 · Cited by 358
Elevated insular glutamate in fibromyalgia is associated with experimental pain
Harris, R. E., Sundgren, P. C., Craig, A. D., Kirshenbaum, E., Sen, A., Napadow, V., & Clauw, D. J. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24849 · Cited by 328
Self-citation
Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis
Imamura, M., Imamura, S. T., Kaziyama, H. H. S., Targino, R. A., Hsing, W. T., de Souza, L. P. M., Cutait, M. M., Fregni, F., & Camanho, G. L. (2008) · Arthritis Care & Research · doi:10.1002/art.24120 · Cited by 327
Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study
Bajaj, P., Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Pain · doi:10.1016/s0304-3959(01)00300-1 · Cited by 317
Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: A 13-week, randomized, placebo-controlled trial
Chappell, A. S., Ossanna, M. J., Liu‐Seifert, H., Iyengar, S., Skljarevski, V., LI, L. C., Bennett, R. M., & Collins, H. (2009) · Pain · doi:10.1016/j.pain.2009.06.024 · Cited by 295
Milnacipran for the treatment of fibromyalgia in adults: A 15-week, multicenter, randomized, double-blind, placebo-controlled, multiple-dose clinical trial
Clauw, D. J., Mease, P. J., Palmer, R. H., Gendreau, R. M., & Wang, Y. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.11.009 · Cited by 254
Self-citation
The Efficacy and Safety of Milnacipran for Treatment of Fibromyalgia. A Randomized, Double-blind, Placebo-controlled Trial
Mease, P. J., Clauw, D. J., Gendreau, R. M., Rao, S. G., Kranzler, J., CHEN, W., & Palmer, R. H. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.080734 · Cited by 248
Self-citation
Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): A 6-month, double-blind, placebo-controlled trial with pregabalin
Crofford, L. J., Mease, P. J., Simpson, S. L., Young, J. P., Martin, S. A., Haig, G. M., & Sharma, U. (2008) · Pain · doi:10.1016/j.pain.2008.02.027 · Cited by 236
Efficacy of milnacipran in patients with fibromyalgia.
Gendreau, R. M., Thorn, M. D., Gendreau, J., Kranzler, J., Ribeiro, S. C. M., Gracely, R. H., Williams, D. A., Mease, P. J., McLean, S. A., & Clauw, D. J. (2005) · PubMed · Cited by 234
Self-citation
Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizing
Geisser, M. E., Casey, K. L., Brucksch, C. B., Ribbens-Grimm, C., Appleton, B. E., & Crofford, L. J. (2003) · Pain · doi:10.1016/s0304-3959(02)00417-7 · Cited by 233
Arthritic pain is processed in brain areas concerned with emotions and fear
Kulkarni, B., Bentley, D. E., Elliott, R., Julyan, P. J., Boger, E. J., Watson, A., Boyle, Y., El‐Deredy, W., & Jones, A. K. P. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22460 · Cited by 218
A Psychophysical Study of Auditory and Pressure Sensitivity in Patients With Fibromyalgia and Healthy Controls
Geisser, M. E., Glass, J. M., Rajcevska, L. D., Clauw, D. J., Williams, D. A., Kileny, P. R., & Gracely, R. H. (2008) · Journal of Pain · doi:10.1016/j.jpain.2007.12.006 · Cited by 217
Self-citation
Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: A randomized, double-blind, placebo-controlled study
Staud, R. M., Nagel, S., Robinson, M. E., & Price, D. D. (2009) · Pain · doi:10.1016/j.pain.2009.05.020 · Cited by 202
Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia
Harris, R. E., Sundgren, P. C., Pang, Y., Hsu, M. C., Petrou, M., Kim, S., McLean, S. A., Gracely, R. H., & Clauw, D. J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23223 · Cited by 199
Self-citation
Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines
Schaible, H., Ebersberger, A., & Natura, G. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3305 · Cited by 198
Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis
Leffler, A., Kosek, E., Lerndal, T., Nordmark, B., & Hansson, P. T. (2002) · European Journal of Pain · doi:10.1053/eujp.2001.0313 · Cited by 195
The T102C Polymorphism of the 5-HT2A-Receptor Gene in Fibromyalgia
Bondy, B., Spaeth, M., Offenbächer, M., Glatzeder, K., Stratz, T., Schwarz, M., de Jonge, S., Krüger, M., Engel, R. R., Färber, L., et al. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0262 · Cited by 192
Patient Safety Is Not Enough: Targeting Quality Improvements To Optimize the Health of the Population
Woolf, S. H. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-1-200401060-00009 · Cited by 185
Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
Vargas‐Alarcón, G., Fragoso, J. M., Cruz‐Robles, D., Vargas, A., Vargas, A., Lao-Villadóniga, J. I., Garcia-Fructuoso, F. J., Ramos-Kuri, M., Hernández, F., Springall, R., et al. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2316 · Cited by 171
Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain
Baraniuk, J. N., Whalen, G., Cunningham, J., & Clauw, D. J. (2004) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-5-48 · Cited by 167
Self-citation
Assessment of pain in rheumatoid arthritis: minimal clinically significant difference, predictors, and the effect of anti-tumor necrosis factor therapy.
Wolfe, F., & Michaud, K. D. (2007) · PubMed · Cited by 165
Investigation into the neural correlates of emotional augmentation of clinical pain
Schweinhardt, P., Kalk, N. J., Wartolowska, K. A., Chessell, I. P., Wordsworth, B. P., & Tracey, I. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.016 · Cited by 160
Sleep continuity and architecture: Associations with pain‐inhibitory processes in patients with temporomandibular joint disorder
Edwards, R. R., Grace, E., Peterson, S., Klick, B., Haythornthwaite, J. A., & Smith, M. T. (2009) · European Journal of Pain · doi:10.1016/j.ejpain.2008.12.007 · Cited by 158
Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome.
Buskila, D., & Sarzi‐Puttini, P. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2005 · Cited by 157
CHANGES IN CENTRAL OPIOID RECEPTOR BINDING IN RELATION TO INFLAMMATION AND PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS
Jones, A. K. P., Cunningham, V. J., Ha-Kawa, S., FUJIWARA, T., Luthra, S. K., SILVA, S., Derbyshire, S. W. G., & Jones, T. (1994) · Lara D. Veeken · doi:10.1093/rheumatology/33.10.909 · Cited by 156
Contribution of the local and referred pain from active myofascial trigger points in fibromyalgia syndrome
Ge, H., Nie, H., Madeleine, P., Danneskiold‐Samsøe, B., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2009) · Pain · doi:10.1016/j.pain.2009.09.019 · Cited by 152
Effects of treatment of peripheral pain generators in fibromyalgia patients
Affaitati, G., Costantini, R., Fabrizio, A., Lapenna, D., Tafuri, E., & Giamberardino, M. A. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.09.002 · Cited by 151
Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain
Arendt‐Nielsen, L., Nielsen, J., Petersen‐Felix, S., Schnider, T. W., & Zbinden, A. M. (1996) · British Journal of Anaesthesia · doi:10.1093/bja/77.5.625 · Cited by 147
The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study
Lee, Y., Chibnik, L. B., Lü, B., Wasan, A. D., Edwards, R. R., Fossel, A. H., Helfgott, S. M., Solomon, D. H., Clauw, D. J., & Karlson, E. W. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2842 · Cited by 146
Self-citation
Descending Serotonergic Facilitation and the Antinociceptive Effects of Pregabalin in a Rat Model of Osteoarthritic Pain
Rahman, W., Bauer, C. S., Bannister, K., Vonsy, J. L., DOLPHIN, A. C., & Dickenson, A. H. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-45 · Cited by 137
Comorbid Somatic Symptoms and Functional Status in Patients With Fibromyalgia and Chronic Fatigue Syndrome: Sensory Amplification as a Common Mechanism
Geisser, M. E., Donnell, C. S., Petzke, F. W., Gracely, R. H., Clauw, D. J., & Williams, D. A. (2008) · Psychosomatics · doi:10.1176/appi.psy.49.3.235 · Cited by 111
Self-citation
Measurement of pain threshold in patients with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and healthy controls
Gerecz-Simon, E. M., Tunks, E., Heale, J. A., Kean, W. F., & Buchanan, W. W. (1989) · Clinical Rheumatology · doi:10.1007/bf02032098 · Cited by 108
Reduced cortical responses to noxious heat in patients with rheumatoid arthritis
Jones, A. K. P., & Derbyshire, S. W. G. (1997) · Annals of the Rheumatic Diseases · doi:10.1136/ard.56.10.601 · Cited by 106
Antidepressant analgesia in rheumatoid arthritis.
Frank, R. G., Kashani, J. H., Parker, J. C., Beck, N. C., Brownlee-Duffeck, M., Elliott, T. R., Haut, A. E., Atwood, C., Smith, E., & Kay, D. R. (1988) · PubMed · Cited by 105
Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis
Morris, V. H., Cruwys, S., & Kidd, B. L. (1997) · Pain · doi:10.1016/s0304-3959(97)03361-7 · Cited by 103
The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia.
Cohen, H., Neumann, L., Glazer, Y., Ebstein, R. P., & Buskila, D. (2009) · PubMed · Cited by 97
Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy
Nishishinya, B., Urrútia, G., Walitt, B. T., Rodríguez, A., Bonfill, X., Alegre, C., & Darko, G. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken317 · Cited by 96
The Reliability and Vatidity of Pain Threshold Measurements in Osteoarthritis of the Knee
Wessel, J. (1995) · Scandinavian Journal of Rheumatology · doi:10.3109/03009749509100881 · Cited by 93
Pain and hyperalgesia in osteoarthritis of the hands.
Farrell, M. J., Gibson, S., McMeeken, J. M., & Helme, R. D. (2000) · PubMed · Cited by 90
Report of the American College of Rheumatology Pain Management Task Force
American College of Rheumatology Pain Management Task Force (2010) · Arthritis Care & Research · doi:10.1002/acr.20005 · Cited by 90
Absence of Association of the Serotonin Transporter Gene Polymorphism with the Mentally Healthy Subset of Fibromyalgia Patients
Gürsoy, S. (2002) · Clinical Rheumatology · doi:10.1007/s10067-002-8284-5 · Cited by 83
Developments in the scientific and clinical understanding of fibromyalgia
Buskila, D. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2720 · Cited by 81
No relationship between the ins del polymorphism of the serotonin transporter promoter and pain perception in fibromyalgia patients and healthy controls
Potvin, S., Larouche, A., Normand, E., de Souza, J. B., Gaumond, I., Marchand, S., & Grignon, S. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2009.12.004 · Cited by 71
Pain Threshold and Arthritis
HUSKISSON, E. C., & Hart, F. D. (1972) · BMJ · doi:10.1136/bmj.4.5834.193 · Cited by 69
A clinical trial of Tofranil in rheumatic pain in general practice.
Gringras, M. (1976) · PubMed · Cited by 67
Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility
Tander, B., Gunes, S. O., Böke, Ö., Alaylı, G., Kara, N., Bağcı, H., & Cantürk, F. (2008) · Rheumatology International · doi:10.1007/s00296-008-0525-8 · Cited by 66
The effects of dothiepin on subjects with rheumatoid arthritis and depression
Ash, G., Dickens, C. M., Creed, F. H., Jayson, M. I. V., & Tomenson, B. (1999) · Rheumatology · doi:10.1093/rheumatology/38.10.959 · Cited by 66
A Comparison of Dothiepin versus Placebo in the Treatment of Pain in Rheumatoid Arthritis and the Association of Pain with Depression
Puttini, P. S., Cazzola, M., Boccassini, L., Ciniselli, G., Santandrea, S., Caruso, I., & Benvenuti, C. (1988) · Journal of International Medical Research · doi:10.1177/030006058801600502 · Cited by 46
Trimipramine in rheumatoid arthritis: a randomized double-blind trial in relieving pain and joint tenderness
Macfarlane, J., Jalali, S., & Grace, E. M. (1986) · Current Medical Research and Opinion · doi:10.1185/03007998609110424 · Cited by 44
Patients with rheumatoid arthritis adapt differently to repetitive painful stimuli compared to healthy controls
Wendler, J., Hummel, T. R., Reissinger, M., Manger, B., Pauli, E., Kalden, J. R., & Kobal, G. (2001) · Journal of Clinical Neuroscience · doi:10.1054/jocn.1999.0775 · Cited by 39
Pain Threshold Analysis in Patients with Osteoarthrosis of Hip
O'Driscoll, S. L., & Jayson, M. I. V. (1974) · BMJ · doi:10.1136/bmj.3.5933.714 · Cited by 35
The relation of extraarticular tenderness to inflammatory joint disease and personality in patients with rheumatoid arthritis.
Konttinen, Y. T., Honkanen, V., Grönblad, M., Keinonen, M., Santavirta, N., & Santavirta, S. S. (1992) · PubMed · Cited by 30
Course of patient-reported health outcomes in rheumatoid arthritis: comparison of longitudinal and cross-sectional approaches.
Rupp, I., Boshuizen, H. C., Roorda, L. D., Dinant, H. J., Jacobi, C. E., & van den Bos, G. A. M. (2006) · PubMed · Cited by 22
Corrigendum to “Investigation into the neural correlates of emotional augmentation of clinical pain” [Neuroimage 40/2 (2008) 759–766]
Schweinhardt, P., Kalk, N. J., Wartolowska, K. A., Chessell, I. P., Wordsworth, B. P., & Tracey, I. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.047 · Cited by 8
The effects of dothiepin on subjects with rheumatoid arthritis and depression
Chuck, A. (2000) · British journal of rheumatology · doi:10.1093/rheumatology/39.12.1425 · Cited by 5
Corrigendum to "Investigation into the neural correlates of emotional augmentation of clinical pain" [Neuroimage 40/2 (2008) 759-766] (DOI:10.1016/j.neuroimage.2007.12.016)
Schweinhardt, P., Kalk, N. J., Wartolowska, K., et al. (2011) · NeuroImage · Cited by 4
Reply
Griffiths, D. J., & Venables, P. J. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199911)42:11 · Cited by 1

Flagged first, then by citations

Sorted by citations

Fibromyalgia: A Clinical Review
Clauw, D. J. (2014) · JAMA · doi:10.1001/jama.2014.3266 · Cited by 1,674
Self-citation
The association of sleep and pain: an update and a path forward
Finan, P. H., Goodin, B. R., & Smith, M. T. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.08.007 · Cited by 1,620
Assessment and manifestation of central sensitisation across different chronic pain conditions
Arendt‐Nielsen, L., Morlion, B., Perrot, S., Dahan, A., Dickenson, A., Kress, H. G., Wells, C., Bouhassira, D., & Drewes, A. M. (2018) · European Journal of Pain · doi:10.1002/ejp.1140 · Cited by 695
Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications
Haack, M., Simpson, N. S., Sethna, N. F., Kaur, S., & Mullington, J. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0439-z · Cited by 696
Discordance between pain and radiographic severity in knee osteoarthritis: Findings from quantitative sensory testing of central sensitization
Finan, P. H., Buenaver, L. F., Bounds, S. C., Hussain, S., Park, R. J., Haque, U. J., Campbell, C. M., Haythornthwaite, J. A., Edwards, R. R., & Smith, M. T. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34646 · Cited by 473

See all 377

Authors: Lee, Y. C., Nassikas, N. J., & Clauw, D. J.
Affiliations: Brigham and Women's Hospital (US)
University of Michigan (US)
Corresponding author: Lee, Yvonne C
ORCID: Lee, Yvonne C
Nassikas, Nicholas J
Clauw, Daniel J
Venue: Arthritis Research & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2011
Volume: 13
Issue: 2
Pages: 211
ISSN: 1478-6354 (ISSN-L)
DOI: 10.1186/ar3306
PMC: PMC3132050
OpenAlex: W2140037651
Cited by: 377
References: 87
Citations by year: 2026: 11 · 2025: 17 · 2024: 21 · 2023: 28 · 2022: 18 · 2021: 38 · 2020: 28 · 2019: 31 · 2018: 30 · 2017: 25 · 2016: 24 · 2015: 24 · 2014: 27 · 2013: 29 · 2012: 23
FWCI: 2.82
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Arthritis Research & Therapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 057578, K23AR057578)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords: chronic pain, central nervous system, rheumatoid arthritis, osteoarthritis, fibromyalgia, central sensitization, widespread pain, pain processing, serotonin-norepinephrine reuptake inhibitors, gabapentinoids, analgesic efficacy
MeSH terms: Animals, Arthritis, Rheumatoid, Central Nervous System, Fibromyalgia, Humans, Osteoarthritis, Chronic Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks