Cited by 377Pain Mechanisms and TreatmentsMusculoskeletal pain and rehabilitationFibromyalgia and Chronic Fatigue Syndrome Research

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The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

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Lee, Yvonne C, Nassikas, Nicholas J, Clauw, Daniel J·2011·Arthritis Research & Therapy

DOI 10.1186/ar3306PMC PMC3132050

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Abstract

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of central nervous system pain mechanisms (for example, loss of descending analgesic activity and central sensitization) is well documented. A few studies have also noted alterations in central pain processing in osteoarthritis, and some data, including the observation of widespread pain sensitivity, suggest that central pain-processing defects may alter the pain response in rheumatoid arthritis patients. When central pain is identified, different classes of analgesics (for example, serotonin-norepinephrine reuptake inhibitors, α2δ ligands) may be more effective than drugs that treat peripheral or nociceptive pain (for example, nonsteroidal anti-inflammatory drugs and opioids).

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Authors: Lee, Y. C., Nassikas, N. J., & Clauw, D. J.
Affiliations: Brigham and Women's Hospital (US)
University of Michigan (US)
Corresponding author: Lee, Yvonne C
ORCID: Lee, Yvonne C
Nassikas, Nicholas J
Clauw, Daniel J
Venue: Arthritis Research & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2011
Volume: 13
Issue: 2
Pages: 211
ISSN: 1478-6354 (ISSN-L)
DOI: 10.1186/ar3306
PMC: PMC3132050
OpenAlex: W2140037651
Cited by: 377
References: 87
Citations by year: 2026: 11 · 2025: 17 · 2024: 21 · 2023: 28 · 2022: 18 · 2021: 38 · 2020: 28 · 2019: 31 · 2018: 30 · 2017: 25 · 2016: 24 · 2015: 24 · 2014: 27 · 2013: 29 · 2012: 23
FWCI: 2.82
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Arthritis Research & Therapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 057578, K23AR057578)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords: chronic pain, central nervous system, rheumatoid arthritis, osteoarthritis, fibromyalgia, central sensitization, widespread pain, pain processing, serotonin-norepinephrine reuptake inhibitors, gabapentinoids, analgesic efficacy
MeSH terms: Animals, Arthritis, Rheumatoid, Central Nervous System, Fibromyalgia, Humans, Osteoarthritis, Chronic Pain

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The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

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