The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis
Open accessAbstract
Bone destruction is a frequent and clinically serious event in patients with rheumatoid arthritis (RA). Local joint destruction can cause joint instability and often necessitates reconstructive or replacement surgery. Moreover, inflammation-induced systemic bone loss is associated with an increased fracture risk. Bone resorption is a well-controlled process that is dependent on the differentiation of monocytes to bone-resorbing osteoclasts. Infiltrating as well as resident synovial cells, such as T cells, monocytes and synovial fibroblasts, have been identified as sources of osteoclast differentiation signals in RA patients. Pro-inflammatory cytokines are amongst the most important mechanisms driving this process. In particular, macrophage colony-stimulating factor, RANKL, TNF, IL-1 and IL-17 may play dominant roles in the pathogenesis of arthritis-associated bone loss. These cytokines activate different intracellular pathways to initiate osteoclast differentiation. Thus, over the past years several promising targets for the treatment of arthritic bone destruction have been defined.
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BackgroundInterleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
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Cited by
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss
Harre, U., Lang, S. C., Pfeifle, R., Rombouts, Y., Frühbeißer, S., Amara, K., Bang, H., Lux, A., Koeleman, C. A., Baum, W., et al. (2015) · Nature Communications · doi:10.1038/ncomms7651 · Cited by 261
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation
Xiu, Y., Xu, H., Zhao, C., Li, J., Morita, Y., Yao, Z., Xing, L., & Boyce, B. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66947 · Cited by 164
Zhao, B., & Ivashkiv, L. B. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3379 · Cited by 144
Bone and the Innate Immune System
Charles, J. F., & Nakamura, M. C. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0195-2 · Cited by 58
Ledesma-Colunga, M. G., Adán, N., Ortiz, G., Solís-Gutiérrez, M., López-Barrera, F., Martínez de la Escalera, G., & Clapp, C. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1290-4 · Cited by 40
Metadata
- Authors
- Braun, T., & Zwerina, J.
- Venue
- Arthritis Research & Therapy
- Published
- 2011
- Volume
- 13
- Issue
- 4
- Pages
- 235
- ISSN
- 1478-6354 (ISSN-L)
- OpenAlex
- W2127141752
- Cited by
- 201
- References
- 19
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
