The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease
Open accessAbstract
Introduction: T cell abnormalities have been associated with the pathogenesis of systemic sclerosis (SSc). Recently, besides T helper (Th)17 cells, the Th22 subset has been identified in humans. Our purpose was to investigate the pattern of cytokines produced and chemokine-receptors expressed by peripheral blood (PB) Th cells in SSc and healthy donors (HD) focusing on cells producing interleukin (IL)-17 and IL-22 and to identify specific clinical associations. Methods: Clinical data and peripheral blood were collected in 33 SSc individuals and 29 HD. IL-17A, IL-22, interferon gamma (IFN-γ), IL-4 production, the chemokine receptors CCR4, CCR6, CCR10, CXCR3 expression and the CD161 Th17 cell marker were assessed by multiparametric flow cytometry in PB CD4+ T cells. Intracellular cytokine accumulation was further investigated in CD4+ T cells expanded in vitro for seven days. Results: The frequency of Th22, Th17, Th2, but not Th1 cells, was significantly increased in SSc individuals compared to HD. The percentage of CD161+CD4+ T cells was increased in SSc and correlated with the percentage of IL-17A producing cells. Moreover, the expression of the skin- and lung-homing chemokine receptor CCR6 correlated with the frequency of IL-22 and IL-17A-producing cells in SSc but not in HD. Finally, SSc interstitial lung disease (ILD) was strongly associated with higher numbers of IL-22 and, to a lesser extent, IL-17A-producing cells. Conclusions: IL-22 and IL-17A-producing T cells with skin- and lung-homing capabilities are characteristically increased in SSc. These findings support the hypothesis that Th22, in addition to Th17 cells, may be involved in pathological processes leading to SSc. While the association between IL-22 producing cells and ILD needs to be assessed in larger cohorts of patients, the increased frequency of Th22 cells appears to be a useful novel biomarker in SSc.
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Cites
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1×
“IL-17A has been reported to induce IL-6 and IL-8 production and intercellular adhesion molecule 1 (ICAM-1) expression in human fibroblasts [42].”
BackgroundProduction of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1767 · Cited by 1,079 · cited 16×
“CCR6 expression correlates with the frequency of IL-17 and IL-22-producing cells in SSc but not in HD We then investigated whether SSc individuals had a skewed pattern of lymphocytes expressing chemokinereceptors involved in skin- (CCR6, CCR4 and CCR10) [10,12] and lung-homing (CCR6) [11,13,36].”
BackgroundInfluentialTrifari, S., Kaplan, C. D., Tran, E. H., Crellin, N. K., & Spits, H. (2009) · Nature Immunology · doi:10.1038/ni.1770 · Cited by 1,021
Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent
Wilson, M. S., Madala, S. K., Ramalingam, T. R., Gochuico, B. R., Rosas, I. O., Cheever, A. W., & Wynn, T. A. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20092121 · Cited by 730
Nograles, K. E., Zaba, L. C., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Kikuchi, T., Ramon, M., Bergman, R., Krueger, J. G., & Guttman-Yassky, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.041 · Cited by 627 · cited 1×
“For instance, the frequency of IL-22+ T cells in skin derived T-cell lines from psoriasis, atopic eczema and allergic contact dermatitis was significantly higher than in the peripheral blood [17,37-39].”
BackgroundPostlethwaite, A. E., Holness, M. A., Katai, H., & Raghow, R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116015 · Cited by 504
Heterogeneity of human effector CD4+ T cells
Annunziato, F., & Romagnani, S. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2843 · Cited by 194
Cited by
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,014
Combinatorial labeling of single cells for gene expression cytometry
Fan, H. C., Fu, G. K., & Fodor, S. P. A. (2015) · Science · doi:10.1126/science.1258367 · Cited by 455
Varga, J., Trojanowska, M., & Kuwana, M. (2017) · Journal of Scleroderma and Related Disorders · doi:10.5301/jsrd.5000249 · Cited by 323
Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis
MacDonald, K. G., Dawson, N. A. J., Huang, Q., Dunne, J. V., Levings, M. K., & Broady, R. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1932 · Cited by 170
IL-22 promotes fibroblast-mediated wound repair in the skin
McGee, H. M., Schmidt, B. A., Booth, C. J., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S., Flavell, R. A., & Horsley, V. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.463 · Cited by 161
Metadata
- Authors
- Truchetet, M.-E., Brembilla, N. C., Montanari, E., Allanore, Y., & Chizzolini, C.
- Venue
- Arthritis Research & Therapy
- Published
- 2011-10-13
- Volume
- 13
- Issue
- 5
- Pages
- R166-R166
- ISSN
- 1478-6354 (ISSN-L)
- OpenAlex
- W2169236770
- Cited by
- 173
- References
- 7
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- Truchetet, M.-E., Brembilla, N. C., Montanari, E., Allanore, Y., & Chizzolini, C. (2011). Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease. Arthritis Research & Therapy. https://doi.org/10.1186/ar3486
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