Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells
Open accessAbstract
Scleroderma (systemic sclerosis; SSc) is characterised by fibrosis of the skin and internal organs in the context of autoimmunity and vascular perturbation. Overproduction of extracellular matrix components and loss of specialised epithelial structures are analogous to the process of scar formation after tissue injury. Fibroblasts are the resident cells of connective tissue that become activated at sites of damage and are likely to be important effector cells in SSc. Differentiation into myofibroblasts is a hallmark process, although the mechanisms and cellular origins of this important fibroblastic cell are still unclear. This article reviews fibroblast biology in the context of SSc and highlights the potentially important place of fibroblast effector cells in fibrosis. Moreover, the heterogeneity of fibroblast properties, multiplicity of regulatory pathways and diversity of origin for myofibroblasts may underpin clinical diversity in SSc, and provide novel avenues for targeted therapy.
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Organs such as kidney, intestine and myocard can also be affected by myofibroblast-driven fibrosis in SSc.
“In addtion, organs such as kidney, intestine and myocard can also be affected by myofibroblast-driven fibrosis in SSc (18).”
From Unraveling SSc Pathophysiology; The Myofibroblast (2018) · cites this paper as [18]
Myofibroblasts have long been associated with SSc pathophysiology.
“Myofibroblasts have long been associated with SSc pathophysiology (18).”
From Unraveling SSc Pathophysiology; The Myofibroblast (2018) · cites this paper as [18]
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Mutations affecting segment number and polarity in Drosophila
Nüsslein‐Volhard, C., & Wieschaus, E. F. (1980) · Nature · doi:10.1038/287795a0 · Cited by 4,370 · see citing works
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · see citing works
TGF-β signaling and the fibrotic response
Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319 · see citing works
Hinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068 · see citing works
Klinge, U., Park, J.-K., & Klosterhalfen, B. (2013) · Pathobiology · doi:10.1159/000348446 · Cited by 1,791 · see citing works
Loeys, B., Chen, J., Neptune, E., Judge, D. P., Podowski, M., Holm, T. M., Meyers, J. L., Leitch, C. C., Katsanis, N., Sharifi, N., et al. (2005) · Nature Genetics · doi:10.1038/ng1511 · Cited by 1,786 · see citing works
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Dráb, M., Verkade, P., Elger, M., Kasper, M. E., Löhn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F. C., et al. (2001) · Science · doi:10.1126/science.1062688 · Cited by 1,555 · see citing works
Gabrielli, A., Avvedimento, E. V., & Krieg, T. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0806188 · Cited by 1,388 · see citing works
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
Bucala, R., Spiegel, L. A., Chesney, J. A., Hogan, M. M., & Cerami, A. (1994) · Molecular Medicine · doi:10.1007/bf03403533 · Cited by 1,307 · see citing works
Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities
Razani, B., Engelman, J. A., Wang, X., Schubert, W., Zhang, X. L., Marks, C. B., Macaluso, F., Russell, R. G., Li, M., Pestell, R. G., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105408200 · Cited by 1,163 · see citing works
Diversity, topographic differentiation, and positional memory in human fibroblasts
Chang, H. Y., Chi, J., Dudoit, S., Bondre, C., van de Rijn, M., Botstein, D., & Brown, P. O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162488599 · Cited by 1,151 · see citing works
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, R. J., Burdick, M. D., Hong, K. M., Lutz, M., Murray, L. A., Xue, Y., Belperio, J. A., Keane, M. P., & Strieter, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20997 · Cited by 1,071 · see citing works
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease
Willis, B. C., & Borok, Z. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00163.2007 · Cited by 1,044 · see citing works
EMT: When epithelial cells decide to become mesenchymal-like cells
Kalluri, R. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39675 · Cited by 953 · see citing works
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
Akhmetshina, A., Palumbo, K., Dees, C., Bergmann, C., Venalis, P., Zerr, P., Horn, A., Kireva, T., Beyer, C., Zwerina, J., et al. (2012) · Nature Communications · doi:10.1038/ncomms1734 · Cited by 843 · see citing works
Razani, B., Zhang, X. L., Bitzer, M., von Gersdorff, G., Böttinger, E. P., & Lisanti, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008340200 · Cited by 640 · see citing works
Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis
Hashimoto, N., Phan, S. H., Imaizumi, K., Matsuo, M., Nakashima, H., Kawabe, T., Shimokata, K., & Hasegawa, Y. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0031oc · Cited by 445 · see citing works
Yamamoto, T., Takagawa, S., Katayama, I., Yamazaki, K., Hamazaki, Y., Shinkai, H., & Nishioka, K. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00528.x · Cited by 434 · see citing works
Dulauroy, S., Di Carlo, S. E., Langa, F., Eberl, G., & Peduto, L. (2012) · Nature Medicine · doi:10.1038/nm.2848 · Cited by 418 · see citing works
Frid, M. G., Kale, V. A., & Stenmark, K. R. (2002) · Circulation Research · doi:10.1161/01.res.0000021432.70309.28 · Cited by 418 · see citing works
Systemic and cell type-specific gene expression patterns in scleroderma skin
Whitfield, M. L., Finlay, D. R., Murray, J. I., Troyanskaya, O. G., Chi, J., Pergamenschikov, A., McCalmont, T. H., Brown, P. O., Botstein, D., & Connolly, M. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1635114100 · Cited by 408 · see citing works
Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis
Andersson‐Sjöland, A., de Alba, C. G., Nihlberg, K., Becerril, C., Ramı́rez, R., Pardo, A., Westergren‐Thorsson, G., & Selman, M. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.012 · Cited by 360 · see citing works
Involvement of functional autoantibodies against vascular receptors in systemic sclerosis
Riemekasten, G., Philippe, A., Näther, M., Slowinski, T., Müller, D. N., Heidecke, H., Matucci‐Cerinic, M., Czirják, L., Lukitsch, I., Becker, M. O., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.135772 · Cited by 308 · see citing works
A stromal address code defined by fibroblasts
Parsonage, G., Filer, A. D., Haworth, O., Nash, G. B., Rainger, G. E., Salmon, M., & Buckley, C. D. (2005) · Trends in Immunology · doi:10.1016/j.it.2004.11.014 · Cited by 297 · see citing works
Rajkumar, V. S., Howell, K., Csiszar, K., Denton, C. P., Black, C. M., & Abraham, D. J. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1790 · Cited by 242 · see citing works
Self-citationWei, J., Fang, F., Lam, A. P., Sargent, J. L., Hamburg, E., Hinchcliff, M. E., Gottardi, C. J., Atit, R., Whitfield, M. L., & Varga, J. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34424 · Cited by 226 · see citing works
Saito, E., Fujimoto, M., Hasegawa, M., Komura, K., Hamaguchi, Y., Kaburagi, Y., Nagaoka, T., Takehara, K., Tedder, T. F., & Sato, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15078 · Cited by 225 · see citing works
Wei, J., Melichian, D., Komura, K., Hinchcliff, M., Lam, A. P., Lafyatis, R., Gottardi, C. J., MacDougald, O. A., & Varga, J. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30312 · Cited by 214 · see citing works
Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1
Eferl, R., Hasselblatt, P., Rath, M., Popper, H., Zenz, R., Komnenovic, V., Idarraga, M. H., Kenner, L., & Wagner, E. F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801414105 · Cited by 207 · see citing works
Sonnylal, S., Denton, C. P., Zheng, B., Keene, D. R., He, R., Adams, H. P., VanPelt, C. S., Geng, Y., Deng, J. M., Behringer, R. R., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22328 · Cited by 198 · see citing works
Self-citationSonnylal, S., Shiwen, X., Leoni, P., Naff, K. A., Pelt, C. S. V., Nakamura, H., Leask, A., Abraham, D., Bou–Gharios, G., & Crombrugghe, B. D. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27382 · Cited by 196 · see citing works
Mechanisms and consequences of fibrosis in systemic sclerosis
Denton, C. P., Black, C. M., & Abraham, D. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0115 · Cited by 181 · see citing works
Self-citationHedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis
Horn, A., Palumbo, K., Cordazzo, C., Dees, C., Akhmetshina, A., Tomčík, M., Zerr, P., Avouac, J., Gusinde, J., Zwerina, J., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34444 · Cited by 162 · see citing works
Lee, C. G., Homer, R., Cohn, L. E., Link, H., Jung, S. S., Craft, J. E., Graham, B. S., Johnson, T. R., & Elias, J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206395200 · Cited by 155 · see citing works
Sargent, J. L., Milano, A., Bhattacharyya, S., Varga, J., Connolly, M. K., Chang, H. Y., & Whitfield, M. L. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.318 · Cited by 148 · see citing works
Denton, C. P., Zheng, B., Evans, L. A., Shiwen, X., Ong, V. H., Fisher, I. B., Lazaridis, K., Abraham, D., Black, C. M., & Crombrugghe, B. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300636200 · Cited by 141 · see citing works
Self-citationChen, Y., Shiwen, X., Beek, J. V., Kennedy, L., McLeod, M. R., Renzoni, E. A., Bou–Gharios, G., Wilcox‐Adelman, S. A., Goetinck, P. F., Eastwood, M., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61252-7 · Cited by 135 · see citing works
Chan, E. S. L., Fernandez, P., Merchant, A., Montesinos, M. C., Trzaska, S., Desai, A., Tung, C., Khoa, D. N. Y., Pillinger, M. H., Reiss, A. B., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21974 · Cited by 134 · see citing works
Hoyles, R. K., Derrett‐Smith, E. C., Khan, K., Shiwen, X., Howat, S., Wells, A. U., Abraham, D., & Denton, C. P. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201002-0279oc · Cited by 128 · see citing works
Self-citationShiwen, X., Renzoni, E. A., Kennedy, L., Howat, S., Chen, Y., Pearson, J. D., Bou–Gharios, G., Dashwood, M. R., du Bois, R. M., Black, C. M., et al. (2007) · Matrix Biology · doi:10.1016/j.matbio.2007.06.003 · Cited by 116 · see citing works
Self-citationTargeting ADAM‐17/notch signaling abrogates the development of systemic sclerosis in a murine model
Kavian, N., Servettaz, A., Mongaret, C., Wang, A. A., Nicco, C., Chéreau, C., Grange, P., Vuiblet, V., Birembaut, P. L., Diébold, M.-D., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27626 · Cited by 113 · see citing works
Endothelial-Mesenchymal Transition Occurs during Embryonic Pulmonary Artery Development
Arciniegas, E., Neves, C. Y., Carrillo, L. M., Zambrano, E. A., & Ramírez, R. (2005) · Endothelium · doi:10.1080/10623320500227283 · Cited by 107 · see citing works
Tourkina, E., Bonner, M., Oates, J., Hofbauer, A., Richard, M., Znoyko, S., Visconti, R. P., Zhang, J., Hatfield, C. M., Silver, R. M., et al. (2011) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-4-15 · Cited by 104 · see citing works
Avouac, J., Palumbo, K., Tomčík, M., Zerr, P., Dees, C., Horn, A., Maurer, B., Akhmetshina, A., Beyer, C., Sadowski, A., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33501 · Cited by 96 · see citing works
Autoantibodies in systemic sclerosis and fibrosing syndromes: clinical indications and relevance
Cepeda, E. J., & Reveille, J. D. (2004) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000144760.37777.fa · Cited by 93 · see citing works
Young‐Min, S. A., Beeton, C. A., Laughton, R., Plumpton, T. A., Bartram, S., Murphy, G., Black, C. M., & Cawston, T. E. (2001) · Annals of the Rheumatic Diseases · doi:10.1016/s0003-4967(24)43384-0 · Cited by 83 · see citing works
McAnulty, R. J., Campa, J. S., Cambrey, A. D., & Laurent, G. J. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(91)90066-7 · Cited by 82 · see citing works
Horn, A., Kireva, T., Palumbo‐Zerr, K., Dees, C., Tomčík, M., Cordazzo, C., Zerr, P., Akhmetshina, A., Ruat, M., Distler, O., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200883 · Cited by 81 · see citing works
Greenblatt, M. B., Sargent, J. L., Farina, G. A., Tsang, K., Lafyatis, R., Glimcher, L. H., Whitfield, M. L., & Aliprantis, A. O. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.024 · Cited by 81 · see citing works
New Insights into the Role of Oxidative Stress in Scleroderma Fibrosis
Gabrielli, A., Svegliati, S., Moroncini, G., & Amico, D. (2012) · The Open Rheumatology Journal · doi:10.2174/1874312901206010087 · Cited by 76 · see citing works
Chesney, J. A., & Bucala, R. (1997) · Biochemical Society Transactions · doi:10.1042/bst0250520 · Cited by 67 · see citing works
Shiwen, X., Thompson, K., Khan, K., Liu, S., Murphy‐Marshman, H., Baron, M. G., Denton, C. P., Leask, A., & Abraham, D. (2012) · Lara D. Veeken · doi:10.1093/rheumatology/kes234 · Cited by 65 · see citing works
Self-citationThe Relaxin Gene Knockout Mouse: A Model of Progressive Scleroderma
Samuel, C. S., Zhao, C., Yang, Q., Wang, H., Tian, H., Tregear, G. W., & Amento, E. P. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23880.x · Cited by 64 · see citing works
Hoyles, R. K., Khan, K., Shiwen, X., Howat, S., Lindahl, G. E., Leoni, P., du Bois, R. M., Wells, A. U., Black, C. M., Abraham, D., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23379 · Cited by 60 · see citing works
Self-citationCirculating fibrocytes are increased in children and young adults with pulmonary hypertension
Yeager, M. E., Nguyen, C. M., Belchenko, D. D., Colvin, K. L., Takatsuki, S., Ivy, D. D., & Stenmark, K. R. (2011) · European Respiratory Journal · doi:10.1183/09031936.00072311 · Cited by 56 · see citing works
Demonstration of Autoimmunity in the Tight Skin-2 Mouse: A Model for Scleroderma
Gentiletti, J., McCloskey, L. J., Artlett, C. M., Peters, J., Jiménez, S. A., & Christner, P. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2418 · Cited by 54 · see citing works
Katebi, M., Fernández, P., Chan, E. S. L., & Cronstein, B. N. (2008) · Inflammation · doi:10.1007/s10753-008-9078-y · Cited by 52 · see citing works
Gut fibrosis with altered colonic contractility in a mouse model of scleroderma
Thoua, N. M., Derrett‐Smith, E. C., Khan, K., Dooley, A., Shiwen, X., & Denton, C. P. (2012) · Lara D. Veeken · doi:10.1093/rheumatology/kes191 · Cited by 43 · see citing works
Self-citationMarkers of joint destruction: principles, problems, and potential
Young‐Min, S. A., CAWSTON, T. E., & GRIFFITHS, I. D. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.6.545a · Cited by 37 · see citing works
Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma
Derrett‐Smith, E. C., Dooley, A., Khan, K., Shiwen, X., Abraham, D., & Denton, C. P. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2986 · Cited by 31 · see citing works
Self-citationThe Role of Fibrocytes in Sickle Cell Lung Disease
Field, J. J., Burdick, M. D., DeBaun, M. R., Strieter, B. A., Liu, L., Mehrad, B., Rose, C. E., Linden, J., & Strieter, R. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033702 · Cited by 23 · see citing works
Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma
Leask, A. (2012) · The Open Rheumatology Journal · doi:10.2174/1874312901206010163 · Cited by 22 · see citing works
Budd, D. C., & Holmes, A. M. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.06.001 · Cited by 21 · see citing works
Self-citationHeart involvement in patients with systemic sclerosis is mimicked by Fra-2 transgenic mice
Venalis, P., Distler, O., Lundberg, I. E., Schett, G. A., & Distler, J. H. W. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-201235.10 · Cited by 1 · see citing works
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- Sonnylal S Denton CP Zheng B Keene DR He R Adams HP Vanpelt CS Geng YJ Deng JM Behringer RR de Crombrugghe B Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma Arthritis Rheum 2007 15 334 344 10.1002/art.22328 17195237 · DOI
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Denton, C. P., & Khanna, D. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30933-9 · Cited by 2,257 · see citing works
Self-citationFibroblasts in fibrosis: novel roles and mediators
Kendall, R. T., & Feghali-Bostwick, C. A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00123 · Cited by 1,082 · see citing works
Good, R. B., Gilbane, A. J., Trinder, S. L., Denton, C. P., Coghlan, G., Abraham, D. J., & Holmes, A. M. (2015) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.03.019 · Cited by 349 · see citing works
Self-citationThe JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer
Hammouda, M., Ford, A. E., Liu, Y., & Zhang, J. Y. (2020) · Cells · doi:10.3390/cells9040857 · Cited by 289 · see citing works
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Piera-Velázquez, S., Mendoza, F. A., & Jiménez, S. A. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5040045 · Cited by 276 · see citing works
The innate immune system, toll-like receptors and dermal wound healing: A review
Portou, M. J., Baker, D., Abraham, D., & Tsui, J. C. S. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.02.007 · Cited by 233 · see citing works
Wang, D., Zhang, H., Li, M., Frid, M. G., Flockton, A. R., McKeon, B. A., Yeager, M. E., Fini, M. A., Morrell, N. W., Pullamsetti, S. S., et al. (2013) · Circulation Research · doi:10.1161/circresaha.114.301633 · Cited by 215 · see citing works
Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis
Maugeri, N., Capobianco, A., Rovere, P. Q., Ramirez, G. A., Tombetti, E., Valle, P. D., Monno, A., D’Alberti, V., Gasparri, A. M., Franchini, S., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao3089 · Cited by 215 · see citing works
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Zhang, Y., & Beachy, P. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00591-1 · Cited by 203 · see citing works
Denton, C. P., Ong, V. H., Xu, S., Chen-Harris, H., Modrusan, Z., Lafyatis, R., Khanna, D., Jahreis, A., Siegel, J., & Sornasse, T. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213031 · Cited by 166 · see citing works
Self-citationHeindryckx, F., Binet, F., Ponticos, M., Rombouts, K., Lau, J., Kreuger, J., & Gerwins, P. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505925 · Cited by 166 · see citing works
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Sánchez‐Duffhues, G., de Vinuesa, A. G., & ten Dijke, P. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24589 · Cited by 143 · see citing works
Wermuth, P. J., & Jiménez, S. A. (2015) · Clinical and Translational Medicine · doi:10.1186/s40169-015-0047-4 · Cited by 138 · see citing works
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López‐Cabrera, M. (2014) · Advances in Medicine · doi:10.1155/2014/473134 · Cited by 105 · see citing works
Jiménez, S. A., & Piera-Velázquez, S. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.012 · Cited by 104 · see citing works
Haak, A. J., Tsou, P.-S., Amin, M. A., Ruth, J. H., Campbell, P., Fox, D. A., Khanna, D., Larsen, S. D., & Neubig, R. R. (2014) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.213520 · Cited by 103 · see citing works
Wasson, C. W., Abignano, G., Hermes, H. M., Malaab, M., Ross, R. L., Jiménez, S. A., Chang, H. Y., Feghali‐Bostwick, C. A., & Galdo, F. D. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-216542 · Cited by 97 · see citing works
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis
Shiwen, X., Stratton, R. J., Nikitorowicz-Buniak, J., Abdi, B. A., Ponticos, M., Denton, C. P., Abraham, D., Takahashi, A., Suki, B., Layne, M. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126015 · Cited by 95 · see citing works
Self-citationdel Río, C., Navarrete, C. M., Collado, J. A., Bellido, M. L., Gómez‐Cañas, M., Pazos, M. R., Fernández‐Ruíz, J., Pollastro, F., Appendino, G., Calzado, M. A., et al. (2016) · Scientific Reports · doi:10.1038/srep21703 · Cited by 93 · see citing works
Pathogenesis of systemic sclerosis—current concept and emerging treatments
Furue, M., Mitoma, C., Mitoma, H., Tsuji, G., Chiba, T., Nakahara, T., Uchi, H., & Kadono, T. (2017) · Immunologic Research · doi:10.1007/s12026-017-8926-y · Cited by 93 · see citing works
Pathogenesis of systemic sclerosis associated interstitial lung disease
Nihtyanova, S. I., & Denton, C. P. (2020) · Journal of Scleroderma and Related Disorders · doi:10.1177/2397198320903867 · Cited by 89 · see citing works
Self-citationFerri, C., Sebastiani, M., Monaco, A. L., Iudici, M., Giuggioli, D., Furini, F., Manfredi, A., Cuomo, G., Spinella, A., Colaci, M., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.08.029 · Cited by 88 · see citing works
Major lung complications of systemic sclerosis
Denton, C. P., Wells, A. U., & Coghlan, G. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0062-0 · Cited by 85 · see citing works
Self-citationAdvances in pathogenesis and treatment of systemic sclerosis
Denton, C. P. (2016) · Clinical Medicine · doi:10.7861/clinmedicine.16-1-55 · Cited by 82 · see citing works
Self-citationVolkmann, E. R., & Tashkin, D. P. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201606-426fr · Cited by 81 · see citing works
Fibroblast Memory in Development, Homeostasis and Disease
Kirk, T., Ahmed, A., & Rognoni, E. (2021) · Cells · doi:10.3390/cells10112840 · Cited by 78 · see citing works
T cell abnormalities in systemic sclerosis
Jin, W., Zheng, Y., & Zhu, P. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103185 · Cited by 78 · see citing works
Escape from X chromosome inactivation and female bias of autoimmune diseases
Mousavi, M. J., Mahmoudi, M., & Ghotloo, S. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00256-1 · Cited by 76 · see citing works
Vascular biomarkers and correlation with peripheral vasculopathy in systemic sclerosis
Chora, I., Guiducci, S., Manetti, M., Romano, E., Mazzotta, C., Bellando-Randone, S., Ibba‐Manneschi, L., Matucci‐Cerinic, M., & Soares, R. A. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.12.001 · Cited by 75 · see citing works
Wermuth, P. J., Piera-Velázquez, S., & Jiménez, S. A. (2017) · PubMed · Cited by 68 · see citing works
Cardiovascular disease in systemic sclerosis
Nordin, A. (2014) · Figshare · Cited by 68 · see citing works
Kanno, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021796 · Cited by 67 · see citing works
Meng, M., Tan, J., Chen, W., Du, Q., Xie, B., Wang, N., Zhu, H., & Wang, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01861 · Cited by 66 · see citing works
Immune-Mediated Repair: A Matter of Plasticity
Laurent, P., Jolivel, V., Manicki, P., Chiu, L., Contin‐Bordes, C., Truchetet, M., & Pradeu, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00454 · Cited by 62 · see citing works
The Role of Fibrinolytic Regulators in Vascular Dysfunction of Systemic Sclerosis
Kanno, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030619 · Cited by 62 · see citing works
Stem cell enriched lipotransfer reverses the effects of fibrosis in systemic sclerosis
Almadori, A., Griffin, M., Ryan, C. M., Hunt, D. F., Hansen, E., Kumar, R., Abraham, D., Denton, C. P., & Butler, P. E. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218068 · Cited by 60 · see citing works
Self-citationAdvances in pathogenesis and treatment of systemic sclerosis
Denton, C. P. (2015) · Clinical Medicine · doi:10.7861/clinmedicine.15-6-s58 · Cited by 60 · see citing works
Self-citationRyu, C., Walia, A., Ortiz, V., Perry, C., Woo, S., Reeves, B. C., Sun, H., Winkler, J., Kanyo, J. E., Wang, W., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41418 · Cited by 58 · see citing works
Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90
Nazari, B., Rice, L. M., Stifano, G., Barron, A., Wang, Y. M., Korndorf, T., Lee, J. E., Bhawan, J., Lafyatis, R., & Browning, J. L. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.06.020 · Cited by 58 · see citing works
Recent Advances in Understanding the Pathogenesis of Scleroderma-Interstitial Lung Disease
Akter, T., Silver, R. M., & Bogatkevich, G. S. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0411-1 · Cited by 57 · see citing works
The molecular pathogenesis of morphoea: from genetics to future treatment targets
Saracino, A., Denton, C. P., & Orteu, C. H. (2016) · British Journal of Dermatology · doi:10.1111/bjd.15001 · Cited by 57 · see citing works
Self-citationJin, J., Ou, Q., Wang, Z., Tian, H., Xu, J., Gao, F., Hu, S., Chen, J., Wang, J., Zhang, J., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02400-y · Cited by 57 · see citing works
Cipriani, P., Benedetto, P. D., Ruscitti, P., Campese, A. F., Liakouli, V., Carubbi, F., Pantano, I., Berardicurt, O., Screpanti, I., & Giacomelli, R. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0442-z · Cited by 56 · see citing works
Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases
Bollenbecker, S., Czaya, B. A., Gutiérrez, O. M., & Krick, S. (2022) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00152.2021 · Cited by 53 · see citing works
Sivanantham, A., Pattarayan, D., Rajasekar, N., Kannan, A., Loganathan, L., Bethunaickan, R., Mahapatra, S. K., Rajaguru, P., Muthusamy, K., & Rajasekaran, S. (2019) · Inflammation Research · doi:10.1007/s00011-019-01282-4 · Cited by 53 · see citing works
Henrot, P., Laurent, P., Levionnois, É., Leleu, D., Pain, C., Truchetet, M., & Cario, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.566607 · Cited by 53 · see citing works
Bagnato, G. L., Irrera, N., Pizzino, G., Santoro, D., Roberts, W. N., Bagnato, G., Pallio, G., Vaccaro, M., Squadrito, F., Saitta, A., et al. (2018) · Clinical Science · doi:10.1042/cs20171426 · Cited by 51 · see citing works
Gilbane, A. J., Derrett‐Smith, E. C., Trinder, S. L., Good, R. B., Pearce, A. C., Denton, C. P., & Holmes, A. M. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201408-1464oc · Cited by 48 · see citing works
Self-citationFerri, C., Arcangeletti, M. C., Caselli, E., Zakrzewska, K., Maccari, C., Calderaro, A., D’Accolti, M., Soffritti, I., Arvia, R., Sighinolfi, G., et al. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102727 · Cited by 48 · see citing works
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis
Paul, S., Kaplan, M. H., Khanna, D., McCourt, P. M., Saha, A. K., Tsou, P., Anand, M., Radecki, A. A., Mourad, M., Sawalha, A. H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34775-8 · Cited by 47 · see citing works
García‐Martín, A., Garrido‐Rodríguez, M., Navarrete, C. M., Caprioglio, D., Palomares, B., DeMesa, J., Rollland, A., Appendino, G., & Muñóz, E. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.02.029 · Cited by 46 · see citing works
Management of Fibrosing Interstitial Lung Diseases
Maher, T. M., & Wuyts, W. A. (2019) · Advances in Therapy · doi:10.1007/s12325-019-00992-9 · Cited by 43 · see citing works
OTUD6B-AS1 Might Be a Novel Regulator of Apoptosis in Systemic Sclerosis
Takata, M., Pachera, E., Frank‐Bertoncelj, M., Kozlova, A., Jüngel, A., Whitfield, M. L., Assassi, S., Calcagni, M., de Vries-Bouwstra, J. K., Huizinga, T. W. J., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01100 · Cited by 41 · see citing works
Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences
Eckel‐Mahan, K. L., Ribas‐Latre, A., & Kolonin, M. G. (2020) · Cells · doi:10.3390/cells9040863 · Cited by 41 · see citing works
Rossi, F. W., Napolitano, F., Pesapane, A., Mascolo, M., Staibano, S., Matucci‐Cerinic, M., Guiducci, S., Ragno, P., Spigna, G. D., Postiglione, L., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402819 · Cited by 41 · see citing works
Strategy for treatment of fibrosis in systemic sclerosis: Present and future
Yanaba, K. (2016) · The Journal of Dermatology · doi:10.1111/1346-8138.13026 · Cited by 40 · see citing works
Huang, M., Cai, G., Baugh, L. M., Liu, Z., Smith, A., Watson, M. C., Popovich, D., Zhang, T., Stawski, L., Trojanowska, M. E., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.41163 · Cited by 40 · see citing works
The contribution of mesenchymal transitions to the pathogenesis of systemic sclerosis
Rosa, I., Romano, E., Fioretto, B. S., & Manetti, M. (2020) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2019.19081 · Cited by 40 · see citing works
Correlation of retinal and choroidal microvascular impairment in systemic sclerosis
Rommel, F., Prangel, D., Prasuhn, M., Grisanti, S., & Ranjbar, M. (2021) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-020-01649-5 · Cited by 40 · see citing works
Nanofibrillar Hydrogel Recapitulates Changes Occurring in the Fibrotic Extracellular Matrix
Prince, E., Chen, Z., Khuu, N., & Kumacheva, E. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.0c01714 · Cited by 40 · see citing works
Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression
Sng, M. K., Chan, J. S. K., Teo, Z. Q., Phua, T., Tan, E. H. P., Wee, J. W. K., Koh, N. J. N., Tan, C. K., Chen, J. P., Pal, M., et al. (2018) · Cell Discovery · doi:10.1038/s41421-018-0014-5 · Cited by 39 · see citing works
del Río, C., Cantarero, I., Palomares, B., Gómez‐Cañas, M., Fernández‐Ruíz, J., Pavicic, C., García‐Martín, A., Bellido, M. L., Castro, R. O., Pérez‐Sánchez, C., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14450 · Cited by 38 · see citing works
The role of metabolism in the pathogenesis of systemic sclerosis
Zhu, H., Chen, W., Liu, D., & Luo, H. (2018) · Metabolism · doi:10.1016/j.metabol.2018.12.004 · Cited by 38 · see citing works
Valentini, G. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.002 · Cited by 37 · see citing works
Chora, I., Romano, E., Manetti, M., Mazzotta, C., Costa, R., Machado, V., Cortez, A., Bruni, C., Lepri, G., Guiducci, S., et al. (2017) · The Journal of Rheumatology · doi:10.3899/jrheum.160791 · Cited by 37 · see citing works
M2 Macrophages Promote Collagen Expression and Synthesis in Laryngotracheal Stenosis Fibroblasts
Motz, K., Lina, I. A., Murphy, M. K., Drake, V. E., Davis, R. J., Tsai, H., Feeley, M., Yin, L. X., Ding, D., & Hillel, A. T. (2020) · The Laryngoscope · doi:10.1002/lary.28980 · Cited by 36 · see citing works
Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin
Mirizio, E., Liu, C., Yan, Q., Waltermire, J., Mandel, R., Schollaert, K. L., Konnikova, L., Wang, X., Chen, W., & Torok, K. S. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.669116 · Cited by 35 · see citing works
Zanotti, S., Bragato, C., Zucchella, A., Maggi, L., Mantegazza, R., Morandi, L. O., & Mora, M. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.12.015 · Cited by 34 · see citing works
Jiménez, S. A. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-eular.6222 · Cited by 34 · see citing works
Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis
Carvalheiro, T., Affandi, A. J., Malvar‐Fernández, B., Dullemond, I., Cossu, M., Ottria, A., Mertens, J. S., Giovannone, B., Bonte‐Mineur, F., Kok, M. R., et al. (2019) · Arthritis & Rheumatology · doi:10.1002/art.40915 · Cited by 33 · see citing works
Gao, L. Q., Jiang, D., Geng, J., Dong, R., & Dai, H. (2019) · Experimental Physiology · doi:10.1113/ep088028 · Cited by 33 · see citing works
Nagaraja, S. S., Subramanian, U., & Nagarajan, D. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.105037 · Cited by 31 · see citing works
Role of NLRP3 inflammasome in systemic sclerosis
Lin, C., Jiang, Z., Cao, L., Zou, H., & Zhu, X. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02889-5 · Cited by 31 · see citing works
Treatment of rapidly progressive systemic sclerosis: current and futures perspectives
Mendoza, F. A., Mansoor, M., & Jiménez, S. A. (2015) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2016.1114454 · Cited by 29 · see citing works
Detection of early endothelial damage in patients with Raynaud's phenomenon
Gualtierotti, R., Ingegnoli, F., Griffini, S., Grovetti, E., Borghi, M. O., Bucciarelli, P., Meroni, P. L., & Cugno, M. (2017) · Microvascular Research · doi:10.1016/j.mvr.2017.04.004 · Cited by 27 · see citing works
Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?
Fröhlich, J., & Vinciguerra, M. (2020) · GeroScience · doi:10.1007/s11357-020-00279-w · Cited by 27 · see citing works
Anti-fibrotic effect of a selective estrogen receptor modulator in systemic sclerosis
Kim, Y., Nam, Y., Rim, Y. A., & Ju, J. H. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02987-w · Cited by 26 · see citing works
Angelis, R. D., Ferri, C., Giuggioli, D., Bajocchi, G., Dagna, L., Bellando-Randone, S., Zanframundo, G., Foti, R., Cacciapaglia, F., Cuomo, G., et al. (2023) · RMD Open · doi:10.1136/rmdopen-2022-002890 · Cited by 26 · see citing works
Diddi, S., Bale, S., Pulivendala, G., & Godugu, C. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0527-4 · Cited by 26 · see citing works
Cutolo, M., Gotelli, E., Montagna, P., Tardito, S., Paolino, S., Pizzorni, C., Sulli, A., Smith, V. M., & Soldano, S. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02555-2 · Cited by 25 · see citing works
Miura, S., Iwamoto, H., Namba, M., Yamaguchi, K., Sakamoto, S., Horimasu, Y., Masuda, T., Miyamoto, S., Nakashima, T., Ohshimo, S., et al. (2024) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2023-001803 · Cited by 24 · see citing works
The Risk of Vocal Fold Atrophy after Serial Corticosteroid Injections of the Vocal Fold
Shi, L. L., Giraldez, L., & Johns, M. M. E. (2015) · Journal of Voice · doi:10.1016/j.jvoice.2015.10.004 · Cited by 24 · see citing works
Shibata, A., Kuno, M., Adachi, R., Sato, Y., Hattori, H., Matsuda, A., Okuzono, Y., Igaki, K., Tominari, Y., Takagi, T., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186587 · Cited by 23 · see citing works
The Role of Pro-fibrotic Myofibroblasts in Systemic Sclerosis: From Origin to Therapeutic Targeting
Romano, E., Rosa, I., Fioretto, B. S., Matucci‐Cerinic, M., & Manetti, M. (2021) · Current Molecular Medicine · doi:10.2174/0929867328666210325102749 · Cited by 23 · see citing works
Manetti, M., Romano, E., Rosa, I., Fioretto, B. S., Praino, E., Guiducci, S., Iannone, F., Ibba‐Manneschi, L., & Matucci‐Cerinic, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081256 · Cited by 22 · see citing works
The Pathophysiological Roles of Regulatory T Cells in the Early Phase of Systemic Sclerosis
Kobayashi, S., Nagafuchi, Y., Shoda, H., & Fujio, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.900638 · Cited by 20 · see citing works
Protease Activated Receptor-1 Deficiency Diminishes Bleomycin-Induced Skin Fibrosis
Duitman, J., Ruela-de-Sousa, R. R., Shi, K., de Boer, O. J., Borensztajn, K., Florquin, S., Peppelenbosch, M. P., & Spek, C. A. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00027 · Cited by 19 · see citing works
Systemic sclerosis skin is a primed microenvironment for soft tissue calcification—a hypothesis
Burgess, K. A., Herrick, A. L., & Watson, R. E. B. (2021) · Rheumatology · doi:10.1093/rheumatology/keab156 · Cited by 19 · see citing works
Rho GTPase signaling in rheumatic diseases
Zeng, R., Zhuo, Z., Luo, Y., Sha, W., & Chen, H. H. (2021) · iScience · doi:10.1016/j.isci.2021.103620 · Cited by 19 · see citing works
Intact Calibers of Retinal Vessels in Patients with Systemic Sclerosis
Aissopou, E. K., Bournia, V.-K., Protogerou, A. D., Panopoulos, S., Papaioannou, T., Vlachoyiannopoulos, P. G., Matucci‐Cerinic, M., & Sfikakis, P. P. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.141425 · Cited by 18 · see citing works
Kanno, Y., Shu, E., Kanoh, H., & Seishima, M. (2015) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.12.028 · Cited by 18 · see citing works
Ohta, S., Matsuura, M., Kawashima, Y., Cai, X., Taniguchi, M., Okochi, H., Asano, Y., Sato, S., & Ito, T. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.04.028 · Cited by 18 · see citing works
Corallo, C., Santucci, A., Bernardini, G., Figura, N., Leoncini, R., Riolo, G., Montella, A., Chirico, C., Nuti, R., & Giordano, N. G. (2016) · The Journal of Rheumatology · doi:10.3899/jrheum.160736 · Cited by 17 · see citing works
- Authors
- Gilbane, A. J., Denton, C. P., & Holmes, A. M.
- Affiliations
- The Royal Free Hospital (GB)
- Corresponding author
- Denton, Christopher P
- Venue
- Arthritis Research & Therapy
- Published
- 2013
- Volume
- 15
- Issue
- 3
- Pages
- 215
- ISSN
- 1478-6354 (ISSN-L)
- PMC
- PMC4060542
- OpenAlex
- W2147084913
- Cited by
- 196
- References
- 64
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 14 · 2023: 14 · 2022: 18 · 2021: 21 · 2020: 14 · 2019: 17 · 2018: 17 · 2017: 17 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Arthritis Research & Therapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Versus Arthritis (19920)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Keywords
- systemic sclerosis, fibroblasts, myofibroblasts, fibrosis, extracellular matrix, autoimmunity, fibroblast heterogeneity, fibroblast origin, targeted therapy
- MeSH terms
- Extracellular Matrix, Fibroblasts, Humans, Scleroderma, Systemic
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