The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression
Open accessAbstract
Aberrant activation of a latent embryonic program - known as the epithelial-mesenchymal transition (EMT) - can endow cancer cells with the migratory and invasive capabilities associated with metastatic competence. The induction of EMT entails the loss of epithelial characteristics and the de novo acquisition of a mesenchymal phenotype. In breast cancer, the EMT state has been associated with cancer stem cell properties including expression of the stem cell-associated CD44+/CD24-/low antigenic profile, self-renewal capabilities and resistance to conventional therapies. Intriguingly, EMT features are also associated with stem cells isolated from the normal mouse mammary gland and human breast reduction tissues as well as the highly aggressive metaplastic and claudin-low breast tumor subtypes. This has implications for the origin of these breast tumors as it remains unclear whether they derive from cells that have undergone EMT or whether they represent an expansion of a pre-existing stem cell population that expresses EMT-associated markers to begin with. In the present review, we consider the current evidence connecting EMT and stem cell attributes and discuss the ramifications of these newly recognized links for our understanding of the emergence of distinct breast cancer subtypes and breast cancer progression.
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Cites
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302
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Lim, E., Wu, D., Pal, B., Bouras, T., Asselin-Labat, M.-L., Vaillant, F., Yagita, H., Lindeman, G. J., Smyth, G. K., & Visvader, J. E. (2010) · Breast Cancer Research · doi:10.1186/bcr2560 · Cited by 440
Cited by
Ortiz-Montero, P., Londoño-Vallejo, A., & Vernot, J.-P. (2017) · Cell Communication and Signaling · doi:10.1186/s12964-017-0172-3 · Cited by 428
Autophagy, cancer stem cells and drug resistance
Smith, A. G., & Macleod, K. F. (2019) · The Journal of Pathology · doi:10.1002/path.5222 · Cited by 365
Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer
Janni, W. J., Rack, B., Terstappen, L. W. M. M., Pierga, J.-Y., Taran, F.-A., Fehm, T., Hall, C., de Groot, M. R., Bidard, F.-C., Friedl, T. W. P., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1603 · Cited by 363
Interaction of tumor cells with the microenvironment
Ungefroren, H., Sebens, S., Seidl, D., Lehnert, H., & Hass, R. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-18 · Cited by 333
Hardt, O., Wild, S., Oerlecke, I., Hofmann, K., Luo, S., Wiencek, Y., Kantelhardt, E., Vess, C., Smith, G. P., Schroth, G. P., et al. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.06.010 · Cited by 64
Metadata
- Authors
- May, C. D., Sphyris, N., Evans, K. W., Werden, S. J., Guo, W., & Mani, S. A.
- Venue
- Breast Cancer Research
- Published
- 2011-02
- Volume
- 13
- Issue
- 1
- Pages
- 202-202
- ISSN
- 1465-5411 (ISSN-L)
- 1465-542X
- OpenAlex
- W2163113687
- Cited by
- 333
- References
- 6
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- May, C. D., Sphyris, N., Evans, K. W., Werden, S. J., Guo, W., & Mani, S. A. (2011). Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Research. https://doi.org/10.1186/bcr2789
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
