The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
FIBTEM provides early prediction of massive transfusion in trauma
Open accessAbstract
Introduction: Prediction of massive transfusion (MT) among trauma patients is difficult in the early phase of trauma management. Whole-blood thromboelastometry (ROTEM®) tests provide immediate information about the coagulation status of acute bleeding trauma patients. We investigated their value for early prediction of MT. Methods: This retrospective study included patients admitted to the AUVA Trauma Centre, Salzburg, Austria, with an injury severity score ≥16, from whom blood samples were taken immediately upon admission to the emergency room (ER). ROTEM® analyses (extrinsically-activated test with tissue factor (EXTEM), intrinsically-activated test using ellagic acid (INTEM) and fibrin-based extrinsically activated test with tissue factor and the platelet inhibitor cytochalasin D (FIBTEM) tests) were performed. We divided patients into two groups: massive transfusion (MT, those who received ≥10 units red blood cell concentrate within 24 hours of admission) and non-MT (those who received 0 to 9 units). Results: Of 323 patients included in this study (78.9% male; median age 44 years), 78 were included in the MT group and 245 in the non-MT group. The median injury severity score upon admission to the ER was significantly higher in the MT group than in the non-MT group (42 vs 27, P < 0.0001). EXTEM and INTEM clotting time and clot formation time were significantly prolonged and maximum clot firmness (MCF) was significantly lower in the MT group versus the non-MT group (P < 0.0001 for all comparisons). Of patients admitted with FIBTEM MCF 0 to 3 mm, 85% received MT. The best predictive values for MT were provided by hemoglobin and Quick value (area under receiver operating curve: 0.87 for both parameters). Similarly high predictive values were observed for FIBTEM MCF (0.84) and FIBTEM A10 (clot amplitude at 10 minutes; 0.83). Conclusions: FIBTEM A10 and FIBTEM MCF provided similar predictive values for massive transfusion in trauma patients to the most predictive laboratory parameters. Prospective studies are needed to confirm these findings.
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Schöchl, H., Nienaber, U., Hofer, G., Voelckel, W., Jambor, C., Scharbert, G., Kozek-Langenecker, S., & Solomon, C. (2010) · Critical Care · doi:10.1186/cc8948 · Cited by 637
Self-citationEarly Prediction of Massive Transfusion in Trauma: Simple as ABC (Assessment of Blood Consumption)?
Nunez, T. C., Voskresensky, I. V., Dossett, L. A., Shinall, R., Dutton, W. D., & Cotton, B. A. (2009) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e3181961c35 · Cited by 570
Self-citationFresh Frozen Plasma Should be Given Earlier to Patients Requiring Massive Transfusion
Gonzalez, E. A., Moore, F. A., Holcomb, J. B., Miller, C. C., Kozar, R. A., Todd, S. R., Cocanour, C. S., Balldin, B. C., & McKinley, B. A. (2007) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000250497.08101.8b · Cited by 568
Functional definition and characterization of acute traumatic coagulopathy
Davenport, R., Manson, J., DeʼAth, H., Platton, S., Coates, A., Allard, S., Hart, D., Pearse, R., Pasi, K. J., MacCallum, P., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182281af5 · Cited by 520
Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography
RUGERI, L., LEVRAT, A., DAVID, J. S., DELECROIX, E., FLOCCARD, B., GROS, A., ALLAOUCHICHE, B., & NEGRIER, C. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02319.x · Cited by 491
Malone, D. L., Hess, J. R., & Fingerhut, A. (2006) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/01.ta.0000199549.80731.e6 · Cited by 445
Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations
FRITH, D., GOSLINGS, J. C., GAARDER, C., MAEGELE, M., COHEN, M. J., ALLARD, S., JOHANSSON, P. I., STANWORTH, S., THIEMERMANN, C., & BROHI, K. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03945.x · Cited by 401
Schöchl, H., Nienaber, U., Maegele, M., Hochleitner, G., Primavesi, F., Steitz, B., Arndt, C., Hanke, A., Voelckel, W., & Solomon, C. (2011) · Critical Care · doi:10.1186/cc10078 · Cited by 398
Self-citationSchöchl, H., Frietsch, T., Pavelka, M., & Jámbor, C. (2009) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e31818b2483 · Cited by 393
Self-citationRiskin, D. J., Tsai, T. C., Riskin, L., Hernandez-Boussard, T., Purtill, M., Maggio, P. M., Spain, D. A., & Brundage, S. I. (2009) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2009.04.016 · Cited by 374
Cited by
ROURKE, C., CURRY, N., KHAN, S., TAYLOR, R., RAZA, I., DAVENPORT, R., STANWORTH, S., & BROHI, K. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04752.x · Cited by 553
The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management
Görlinger, K., Pérez-Ferrer, A., Dirkmann, D., Saner, F., Maegele, M., Calatayud, Á. A. P., & Kim, T.-Y. (2019) · Korean Journal of Anesthesiology · doi:10.4097/kja.19169 · Cited by 257
McNamara, H., Kenyon, C., Smith, R., Mallaiah, S., & Barclay, P. (2019) · Anaesthesia · doi:10.1111/anae.14628 · Cited by 154
Walsh, M., Fritz, S., Hake, D., Son, M., Greve, S., Jbara, M., Chitta, S., Fritz, B., Miller, A., K Bader, M., et al. (2016) · Current Drug Targets · doi:10.2174/1389450117666160310153211 · Cited by 58
Hubbard, A., Munoz, I. D., Decker, A., Holcomb, J. B., Schreiber, M. A., Bulger, E. M., Brasel, K. J., Fox, E. E., del Junco, D. J., Wade, C. E., et al. (2013) · Journal of Trauma and Acute Care Surgery · doi:10.1097/ta.0b013e3182914553 · Cited by 32
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Metadata
- Authors
- Schöchl, H., Cotton, B., Inaba, K., Nienaber, U., Fischer, H., Voelckel, W., & Solomon, C.
- Venue
- Critical Care
- Published
- 2011-11-11
- Volume
- 15
- Issue
- 6
- Pages
- R265-R265
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2156773861
- Cited by
- 313
- References
- 32
- FWCI
- 20.91
- Type
- journal article
- Language
- en
- Open access
- gold
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