Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials
Open accessAbstract
Introduction: Randomized trials investigating neuromuscular blocking agents in adult acute respiratory distress syndrome (ARDS) have been inconclusive about effects on mortality, which is very high in this population. Uncertainty also exists about the associated risk of ICU-acquired weakness. Methods: We conducted a systematic review and meta-analysis. We searched the Cochrane (Central) database, MEDLINE, EMBASE, ACP Journal Club, and clinical trial registries for randomized trials investigating survival effects of neuromuscular blocking agents in adults with ARDS. Two independent reviewers abstracted data and assessed methodologic quality. Primary study investigators provided additional unpublished data. Results: Three trials (431 patients; 20 centers; all from the same research group in France) met inclusion criteria for this review. All trials assessed 48-hour infusions of cisatracurium besylate. Short-term infusion of cisatracurium besylate was associated with lower hospital mortality (RR, 0.72; 95% CI, 0.58 to 0.91; P = 0.005; I 2 = 0). This finding was robust on sensitivity analyses. Neuromuscular blockade was also associated with lower risk of barotrauma (RR, 0.43; 95% CI, 0.20 to 0.90; P = 0.02; I 2 = 0), but had no effect on the duration of mechanical ventilation among survivors (MD, 0.25 days; 95% CI, 5.48 to 5.99; P = 0.93; I 2 = 49%), or the risk of ICU-acquired weakness (RR, 1.08; 95% CI, 0.83 to 1.41; P = 0.57; I 2 = 0). Primary studies lacked protracted measurements of weakness. Conclusions: Short-term infusion of cisatracurium besylate reduces hospital mortality and barotrauma and does not appear to increase ICU-acquired weakness for critically ill adults with ARDS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This recommendation was based on a meta-analysis of 3 trials that examined the role of NMBAs in ARDS, showing reduced risks of death (RR 0.72; 95% CI 0.58-0.91) and barotrauma (RR 0.43; 95% CI 0.20-0.90) with the use of cisatracurium infusion.
“This recommendation was based on a meta-analysis of 3 trials that examined the role of NMBAs in ARDS [465–467], showing reduced risks of death (RR 0.72; 95% CI 0.58–0.91) and barotrauma (RR 0.43; 95% CI 0.20–0.90) with the use of cisatracurium infusion [468].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [468]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305 · see citing works
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941 · see citing works
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694 · see citing works
Self-citationBernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746 · see citing works
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun‐Buisson, C., Beale, R. J., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0934-2 · Cited by 6,722 · see citing works
Self-citationIncidence and Outcomes of Acute Lung Injury
Rubenfeld, G. D., Caldwell, E., Peabody, E., Weaver, J., Martin, D. P., Neff, M., Stern, E. J., & Hudson, L. D. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050333 · Cited by 3,684 · see citing works
Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
Papazian, L., Forel, J.-M., Gacouin, A., Penot-Ragon, C., Perrin, G., Loundou, A., Jaber, S., Arnal, J.-M., Perez, D., Seghboyan, J.-M., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005372 · Cited by 2,432 · see citing works
Self-citationBriel, M., Meade, M., Mercat, A., Brower, R. G., Talmor, D., Walter, S. D., Slutsky, A. S., Pullenayegum, E., Zhou, Q., Cook, D., et al. (2010) · JAMA · doi:10.1001/jama.2010.218 · Cited by 1,467 · see citing works
Self-citationSud, S., Friedrich, J. O., Taccone, P., Polli, F., Adhikari, N. K. J., Latini, R., Pesenti, A., Guérin, C., Mancebo, J., Curley, M. A. Q., et al. (2010) · Intensive Care Medicine · doi:10.1007/s00134-009-1748-1 · Cited by 563 · see citing works
Murray, M. J., DeBlock, H. F., Erstad, B. L., Gray, A. W., Jacobi, J., Jordan, C. J., McGee, W. T., McManus, C., Meade, M. O., Nix, S. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002027 · Cited by 514 · see citing works
Self-citationForel, J.-M., Roch, A., Marin, V., Michelet, P., Demory, D., Blache, J.-L., Perrin, G., Gainnier, M., Bongrand, P., & Papazian, L. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000239435.87433.0d · Cited by 400 · see citing works
Self-citationRecent trends in acute lung injury mortality: 1996–2005*
Erickson, S. E., Martin, G. S., Davis, J. L., Matthay, M. A., & Eisner, M. D. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819fefdf · Cited by 397 · see citing works
Garnacho‐Montero, J., Madrazo-Osuna, J., Garmendia, J. L. G., Ortíz-Leyba, C., Jiménez-Jiménez, F., Barrero-Almodóvar, A., Garnacho, C., & Estad, M. R. M.-D. (2001) · Intensive Care Medicine · doi:10.1007/s001340101009 · Cited by 396 · see citing works
Putensen, C., Theuerkauf, N., Zinserling, J., Wrigge, H., & Pelosi, P. P. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-8-200910200-00011 · Cited by 371 · see citing works
Gainnier, M., Roch, A., Forel, J.-M., Thirion, X., Arnal, J.-M., Donati, S., & Papazian, L. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000104114.72614.bc · Cited by 349 · see citing works
Self-citationMurray, M. J., Cowen, J., DeBlock, H., Erstad, B., Gray, A. W., Tescher, A. N., McGee, W. T., Prielipp, R. C., Susla, G., Jacobi, J., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200201000-00021 · Cited by 283 · see citing works
Intensive care unit-acquired weakness
Griffiths, R. D., & Hall, J. B. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181cc4b53 · Cited by 279 · see citing works
Hansen-Flaschen, J. H., Brazinsky, S. A., BASILE, C., & LANKIN, P. N. (1992) · Survey of Anesthesiology · doi:10.1097/00132586-199208000-00047 · Cited by 271 · see citing works
Muscle Weakness in Mechanically Ventilated Patients With Severe Asthma
Leatherman, J. W., Fluegel, W. L., David, W. S., Davies, S. F., & Iber, C. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.5.8630621 · Cited by 257 · see citing works
Hansen-Flaschen, J. H. (1991) · JAMA · doi:10.1001/jama.1991.03470200082040 · Cited by 250 · see citing works
Epidemiology of acute lung injury
MacCallum, N. S., & Evans, T. W. (2005) · Current Opinion in Critical Care · doi:10.1097/00075198-200502000-00007 · Cited by 166 · see citing works
Rhoney, D. H., & Murry, K. R. (2003) · Journal of Intensive Care Medicine · doi:10.1177/0885066603251200 · Cited by 137 · see citing works
Burns, K. E. A., Adhikari, N. K. J., Slutsky, A. S., Guyatt, G. H., Villar, J., Zhang, H., Zhou, Q. X., Cook, D. J., Stewart, T. E., & Meade, M. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014623 · Cited by 99 · see citing works
Self-citationUse of sedatives, analgesics and neuromuscular blocking agents in Danish ICUs 1996/97
Christensen, B. V., & Thunedborg, L. P. (1999) · Intensive Care Medicine · doi:10.1007/s001340050814 · Cited by 89 · see citing works
Neto, A. S., Pereira, V. G. M., Espósito, D. C., Damasceno, M. C. T., & Schultz, M. J. (2012) · Annals of Intensive Care · doi:10.1186/2110-5820-2-33 · Cited by 75 · see citing works
Hansen-Flaschen, J. H., Brazinsky, S. A., Basile, C., & Lanken, P. N. (1991) · PubMed · Cited by 66 · see citing works
Lagneau, F., Dhonneur, G., Plaud, B., Mantz, J., Gillart, T., Duvaldestin, P., Marty, J., Clyti, N., & Pourriat, J.-L. (2002) · Intensive Care Medicine · doi:10.1007/s00134-002-1508-y · Cited by 56 · see citing works
Intensive care sedation of mechanically ventilated patients: a national Swedish survey
Samuelson, K. A. M., Larsson, S., Lundberg, D., & Fridlund, B. (2003) · Intensive and Critical Care Nursing · doi:10.1016/s0964-3397(03)00065-x · Cited by 55 · see citing works
Building consensus on ICU-acquired weakness
Herridge, M. S. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1305-3 · Cited by 24 · see citing works
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun-Buisson, C., Beale, R., et al. (2008) · Critical Care Medicine · doi:10.1097/01.ccm.0000298158.12101.41 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621 · see citing works
Self-citationSurviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Self-citationSurviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002255 · Cited by 3,652 · see citing works
Self-citationSurviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Self-citationAlhazzani, W., Møller, M. H., Arabi, Y. M., Loeb, M., Gong, M. N., Fan, E., Oczkowski, S., Levy, M. M., Derde, L., Dzierba, A., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06022-5 · Cited by 2,105 · see citing works
Self-citationAlhazzani, W. A., Møller, M. H., Arabi, Y. M., Loeb, M. B., Gong, M. N., Fan, E., Oczkowski, S. J. W., Levy, M. M., Derde, L. P. G., Dzierba, A. L., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004363 · Cited by 1,567 · see citing works
Self-citationNolan, J. P., Soar, J., Cariou, A., Cronberg, T., Moulaert, V. R. M., Deakin, C. D., Böttiger, B. W., Friberg, H., Sunde, K., & Sandroni, C. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.018 · Cited by 1,111 · see citing works
Nolan, J. P., Sandroni, C., Böttiger, B. W., Cariou, A., Cronberg, T., Friberg, H., Genbrugge, C., Haywood, K. L., Lilja, G., Moulaert, V. R. M., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06368-4 · Cited by 1,082 · see citing works
Nolan, J. P., Soar, J., Cariou, A., Cronberg, T., Moulaert, V. R. M., Deakin, C. D., Böttiger, B. W., Friberg, H., Sunde, K., & Sandroni, C. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-4051-3 · Cited by 946 · see citing works
Formal guidelines: Management of acute respiratory distress syndrome.
Papazian, L., Aubron, C., Brochard, L., Chiche, J.-D., Combes, A., Dreyfuss, D., Forel, J.-M., Guérin, C., Jaber, S., Mekontso-Dessap, A., et al. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0540-9 · Cited by 761 · see citing works
Self-citationNolan, J. P., Sandroni, C., Böttiger, B. W., Cariou, A., Cronberg, T., Friberg, H., Genbrugge, C., Haywood, K. L., Lilja, G., Moulaert, V. R. M., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.012 · Cited by 722 · see citing works
Murray, M. J., DeBlock, H. F., Erstad, B. L., Gray, A. W., Jacobi, J., Jordan, C. J., McGee, W. T., McManus, C., Meade, M. O., Nix, S. A., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002027 · Cited by 514 · see citing works
Self-citationGuidelines on the management of acute respiratory distress syndrome
Griffiths, M., McAuley, D. F., Perkins, G. D., Barrett, N. A., Blackwood, B., Boyle, A. J., Chee, N., Connolly, B. A., Dark, P. M., Finney, S. J., et al. (2019) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2019-000420 · Cited by 506 · see citing works
A Comprehensive Review of Prone Position in ARDS
Kallet, R. H. (2015) · Respiratory Care · doi:10.4187/respcare.04271 · Cited by 252 · see citing works
Bein, T., Grasso, S., Moerer, O., Quintel, M., Guérin, C., Deja, M., Brondani, A., & Mehta, S. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4325-4 · Cited by 219 · see citing works
Risk factors for intensive care unit-acquired weakness: A systematic review and meta-analysis
Yang, T., Li, Z., Jiang, L., Wang, Y., & Xi, X. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.12964 · Cited by 203 · see citing works
Distinct phenotypes require distinct respiratory management strategies in severe COVID-19
Robba, C., Battaglini, D., Ball, L., Patroniti, N. A., Loconte, M., Brunetti, I., Vena, A., Giacobbe, D. R., Bassetti, M., Rocco, P. R. M., et al. (2020) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2020.103455 · Cited by 185 · see citing works
Bellingan, G. J., Maksimow, M., Howell, D. C. J., Stotz, M., Beale, R. J., Beatty, M., Walsh, T. S., Binning, A. R., Davidson, A., Kuper, M., et al. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70259-5 · Cited by 148 · see citing works
Tonelli, A. R., Zein, J., Adams, J., & Ioannidis, J. P. A. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3272-1 · Cited by 133 · see citing works
Management of ARDS – What Works and What Does Not
Banavasi, H. V. R., Nguyen, P., Osman, H., & Soubani, A. O. (2020) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2020.12.019 · Cited by 131 · see citing works
Schönhofer, B., Geiseler, J. G., Dellweg, D., Fuchs, H. W., Moerer, O., Weber‐Carstens, S., Westhoff, M., Windisch, W., Hirschfeld-Araujo, J., Janssens, U., et al. (2019) · Pneumologie · doi:10.1055/a-1010-8764 · Cited by 126 · see citing works
Acute Respiratory Distress Syndrome: Etiology, Pathogenesis, and Summary on Management
Kaku, S., Nguyen, C. D., Htet, N. N., Tutera, D., Barr, J., Paintal, H. S., & Kuschner, W. G. (2019) · Journal of Intensive Care Medicine · doi:10.1177/0885066619855021 · Cited by 130 · see citing works
Beginning at the ends: telomeres and human disease
Savage, S. A. (2018) · F1000Research · doi:10.12688/f1000research.14068.1 · Cited by 124 · see citing works
Neuromuscular blockade in patients with ARDS: a rapid practice guideline
Alhazzani, W., Belley-Cote, E., Møller, M. H., Angus, D. C., Papazian, L., Arabi, Y. M., Citerio, G., Connolly, B., Denehy, L., Fox-Robichaud, A., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06227-8 · Cited by 123 · see citing works
Self-citationPhysiotherapy management of intensive care unit-acquired weakness
Hodgson, C. L., & Tipping, C. J. (2016) · Journal of physiotherapy · doi:10.1016/j.jphys.2016.10.011 · Cited by 114 · see citing works
Nolan, J. P., Sandroni, C., Cariou, A., Cronberg, T., D’Arrigo, S., Haywood, K. L., Hoedemaekers, A. C. W. E., Lilja, G., Nikolaou, N. I., Olasveengen, T. M., et al. (2025) · Intensive Care Medicine · doi:10.1007/s00134-025-08117-3 · Cited by 113 · see citing works
Price, D. R., Mikkelsen, M. E., Umscheid, C. A., & Armstrong, E. J. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001839 · Cited by 100 · see citing works
Aoyama, H., Uchida, K., Aoyama, K., Pechlivanoglou, P., Englesakis, M. F., Yamada, Y., & Fan, E. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.8116 · Cited by 96 · see citing works
Nolan, J. P., Sandroni, C., Cariou, A., Cronberg, T., D’Arrigo, S., Haywood, K. L., Hoedemaekers, A. C. W. E., Lilja, G., Nikolaou, N. I., Olasveengen, T. M., et al. (2025) · Resuscitation · doi:10.1016/j.resuscitation.2025.110809 · Cited by 103 · see citing works
Acute respiratory distress syndrome: An update and review
Rawal, G., Yadav, S., & Kumar, R. (2016) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2016-0012 · Cited by 97 · see citing works
Prolonged Weaning: S2k Guideline Published by the German Respiratory Society
Schönhofer, B., Geiseler, J. G., Dellweg, D., Fuchs, H. W., Moerer, O., Weber‐Carstens, S., Westhoff, M., & Windisch, W. (2020) · Respiration · doi:10.1159/000510085 · Cited by 94 · see citing works
Meade, M. O., Young, D., Hanna, S., Zhou, Q. X., Bachman, T. E., Bollen, C. W., Slutsky, A. S., Lamb, S. E., Adhikari, N. K. J., Mentzelopoulos, S. D., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201609-1938oc · Cited by 91 · see citing works
Self-citationUpdate in acute respiratory distress syndrome
Koh, Y. (2014) · Journal of Intensive Care · doi:10.1186/2052-0492-2-2 · Cited by 89 · see citing works
Severe community-acquired pneumonia: timely management measures in the first 24 hours
Phua, J., Dean, N. C., Guo, Q., Kuan, W. S., Lim, H. F., & Lim, T. K. (2016) · Critical Care · doi:10.1186/s13054-016-1414-2 · Cited by 86 · see citing works
Duan, E. H., Adhikari, N. K. J., D’Aragon, F., Cook, D. J., Mehta, S., Alhazzani, W. A., Goligher, E. C., Charbonney, E., Arabi, Y. M., Karachi, T., et al. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201612-1042oc · Cited by 86 · see citing works
Self-citationHo, A. T. N., Patolia, S., & Guervilly, C. (2020) · Journal of Intensive Care · doi:10.1186/s40560-020-0431-z · Cited by 74 · see citing works
Sedation and neuromuscular blocking agents in acute respiratory distress syndrome
Bourenne, J., Hraiech, S., Roch, A., Gainnier, M., Papazian, L., & Forel, J.-M. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.07.19 · Cited by 72 · see citing works
Self-citationLentz, S. A., Roginski, M. A., Montrief, T., Ramzy, M. M., Gottlieb, M. A., & Long, B. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.06.082 · Cited by 73 · see citing works
Hraiech, S., Yoshida, T., Annane, D., Duggal, A., Fanelli, V., Gacouin, A., Heunks, L. M. A., Jaber, S., Sottile, P. D., & Papazian, L. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06297-8 · Cited by 63 · see citing works
Self-citationEmerging drugs for treating the acute respiratory distress syndrome
Shaw, T. D., McAuley, D. F., & O’Kane, C. M. (2019) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2019.1591369 · Cited by 63 · see citing works
Tarazan, N., Alshehri, M., Sharif, S., Al Duhailib, Z., Møller, M. H., Belley-Cote, E., Alshahrani, M., Centofanti, J., McIntyre, L., Baw, B., et al. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00348-6 · Cited by 52 · see citing works
Self-citationTo Wean or Not to Wean: A Practical Patient Focused Guide to Ventilator Weaning
Akella, P., Voigt, L. P., & Chawla, S. (2022) · Journal of Intensive Care Medicine · doi:10.1177/08850666221095436 · Cited by 71 · see citing works
Drago, B., Kimura, D., Rovnaghi, C. R., Schwingshackl, A., Rayburn, M. S., Meduri, G. U., & Anand, K. J. S. (2015) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000349 · Cited by 61 · see citing works
The Role of Rescue Therapies in the Treatment of Severe ARDS
Alessandri, F., Pugliese, F. R., & Ranieri, V. M. (2017) · Respiratory Care · doi:10.4187/respcare.05752 · Cited by 60 · see citing works
Management of Refractory Hypoxemia During Venovenous Extracorporeal Membrane Oxygenation for ARDS
Montisci, A., Maj, G., Zangrillo, A., Winterton, D., & Pappalardo, F. (2015) · ASAIO Journal · doi:10.1097/mat.0000000000000207 · Cited by 58 · see citing works
Fielding‐Singh, V., Matthay, M. A., & Calfee, C. S. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003406 · Cited by 57 · see citing works
Acute Respiratory Distress Syndrome and COVID-19: A Literature Review
Hussain, M., Syed, S. K., Fatima, M., Shaukat, S., Saadullah, M., Alqahtani, A., Alqahtani, T., Emran, T. B., Alamri, A. H., Barkat, M. Q., et al. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s334043 · Cited by 56 · see citing works
Adult Respiratory Distress Syndrome Following Cardiac Surgery
Kogan, A., Preisman, S., Levin, S., Raanani, E., & Sternik, L. (2013) · Journal of Cardiac Surgery · doi:10.1111/jocs.12264 · Cited by 55 · see citing works
Clinical Practice Guideline of Acute Respiratory Distress Syndrome
Cho, Y., Moon, J. Y., Shin, E.-S., Kim, J. H., Jung, H., Park, S. Y., Kim, H. C., Sim, Y. S., Rhee, C. K., Lim, J., et al. (2016) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2016.79.4.214 · Cited by 55 · see citing works
Montenegro, F., Unigarro, L., Paredes, G., Moya, T., Romero, A., Torres, L., López, J. C., González, F. E. J., Pozo, G., López‐Cortés, A., et al. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1820329 · Cited by 51 · see citing works
Claesson, J., Freundlich, M., Gunnarsson, I., Laake, J. H., Møller, M. H., Vandvik, P. O., Varpula, T., & Aasmundstad, T. A. (2016) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12713 · Cited by 51 · see citing works
Managing portal hypertension in patients with liver cirrhosis
Sauerbruch, T., Schierwagen, R., & Trebicka, J. (2018) · F1000Research · doi:10.12688/f1000research.13943.1 · Cited by 51 · see citing works
Chang, W., Sun, Q., Peng, F., Xie, J., Qiu, H., & Yang, Y. (2020) · Critical Care · doi:10.1186/s13054-020-2765-2 · Cited by 51 · see citing works
Surviving Sepsis After Burn Campaign
Greenhalgh, D. G., Hill, D. M., Burmeister, D. M., Gus, E. I., Cleland, H. J., Padiglione, A. A., Holden, D., Huss, F. R. M., Chew, M. S., Kubasiak, J., et al. (2023) · Burns · doi:10.1016/j.burns.2023.05.003 · Cited by 53 · see citing works
Sherren, P. B., Shepherd, S. J., Glover, G. W., Meadows, C. I. S., Langrish, C., Ioannou, N., Wyncoll, D. L. A., Daly, K., Gooby, N., Agnew, N., et al. (2015) · Anaesthesia · doi:10.1111/anae.13014 · Cited by 49 · see citing works
Bouju, P., Tadié, J., Barbarot, N., Letheulle, J., Uhel, F., Fillâtre, P., Grillet, G., Goepp, A., Tulzo, Y. L., & Gacouin, A. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0234-0 · Cited by 48 · see citing works
Balancing neuromuscular blockade versus preserved muscle activity
Hraiech, S., Yoshida, T., & Papazian, L. (2015) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000175 · Cited by 42 · see citing works
Self-citationRehabilitation during mechanical ventilation: Review of the recent literature
Ntoumenopoulos, G. (2015) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2015.02.001 · Cited by 42 · see citing works
Wilsterman, M. E. F., de Jager, P., Blokpoel, R. G. T., Frerichs, I., Dijkstra, S. K., Albers, M. J. I. J., Burgerhof, J. G. M., Markhorst, D. G., & Kneyber, M. C. J. (2016) · Annals of Intensive Care · doi:10.1186/s13613-016-0206-9 · Cited by 40 · see citing works
Acute Respiratory Failure in Pediatric Hematopoietic Cell Transplantation: A Multicenter Study*
Rowan, C. M., McArthur, J. A., Hsing, D. D., Gertz, S. J., Smith, L., Loomis, A., Fitzgerald, J. C., Nitu, M. E., Moser, E. A. S., Duncan, C., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003277 · Cited by 39 · see citing works
Emerging drugs for acute lung injury
Impellizzeri, D., Bruschetta, G., Esposito, E., & Cuzzocrea, S. (2015) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2015.1000299 · Cited by 37 · see citing works
Emerging therapies for hemophilia: controversies and unanswered questions
Arruda, V. R., Doshi, B. S., & Samelson‐Jones, B. J. (2018) · F1000Research · doi:10.12688/f1000research.12491.1 · Cited by 36 · see citing works
Neuromuscular Blocking Agents for ARDS: A Systematic Review and Meta-Analysis
Torbic, H., Krishnan, S., Harnegie, M. P., & Duggal, A. (2020) · Respiratory Care · doi:10.4187/respcare.07849 · Cited by 35 · see citing works
Therapeutic strategies in pneumonia: going beyond antibiotics
Müller-Redetzky, H., Lienau, J., Suttorp, N., & Witzenrath, M. (2015) · European Respiratory Review · doi:10.1183/16000617.0034-2015 · Cited by 34 · see citing works
Good practices for prone positioning at the bedside: Construction of a care protocol
de Oliveira, V. M., Weschenfelder, M. E., Deponti, G. N., Condessa, R. L., Loss, S. H., Bairros, P. M. N., Hochegger, T., da Silva, R. D., Rubin, B. D. A., Chisté, M., et al. (2016) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.62.03.287 · Cited by 34 · see citing works
Martin, G. L., Trioux, T., Gaudry, S., Tubach, F., Hajage, D., & Dechartres, A. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005065 · Cited by 22 · see citing works
Nolan, J. P., Soar, J., Cariou, A., Cronberg, T., Moulaert, V. R. M., Deakin, C. D., Böttiger, B. W., Friberg, H., Sunde, K., & Sandroni, C. (2015) · Notfall + Rettungsmedizin · doi:10.1007/s10049-015-0094-9 · Cited by 29 · see citing works
Kallet, R. H., Burns, G. S., Zhuo, H., Ho, K., Phillips, J. S., Pangilinan, L. P., Yip, V., Gomez, A., & Lipnick, M. S. (2017) · Respiratory Care · doi:10.4187/respcare.05268 · Cited by 27 · see citing works
Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity
Weiss, J. P., & Barker, J. H. (2018) · F1000Research · doi:10.12688/f1000research.13977.1 · Cited by 27 · see citing works
Neuromuscular blockers in the acute respiratory distress syndrome: A meta-analysis
Hua, Y., Ou, X., Li, Q., & Zhu, T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227664 · Cited by 28 · see citing works
Is Therapeutic Hypothermia for Acute Respiratory Distress Syndrome the Future?
Hayek, A. J., White, H. D., Ghamande, S. A., Spradley, C. D., & Arroliga, A. C. (2017) · Journal of Intensive Care Medicine · doi:10.1177/0885066617701117 · Cited by 24 · see citing works
Landolf, K. M., Lemieux, S. M., Rose, C. M., Johnston, J. P., Adams, C., Altshuler, J., Berger, K., Dixit, D., Effendi, M. K., Heavner, M. S., et al. (2021) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2637 · Cited by 25 · see citing works
Recent advances in understanding acute respiratory distress syndrome
Wohlrab, P., Kraft, F., Tretter, V. E., Ullrich, R., Markstaller, K., & Klein, K. U. (2018) · F1000Research · doi:10.12688/f1000research.11148.1 · Cited by 24 · see citing works
Valentine, S. L., Kudchadkar, S. R., Ward, S. L., Morrow, B. M., Nadkarni, V., Curley, M. A. Q., & on behalf of the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network (2023) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000003158 · Cited by 24 · see citing works
In vivo lung perfusion rehabilitates sepsis-induced lung injury
Mehaffey, J. H., Charles, E. J., Schubert, S. A., Salmon, M., Sharma, A. K., Money, D., Stoler, M. H., Laubach, V. E., Tribble, C. G., Roeser, M. E., et al. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.08.124 · Cited by 23 · see citing works
Rézaiguia‐Delclaux, S., Laverdure, F., Genty, T., Imbert, A., Pilorge, C., Amaru, P., Sarfati, C., & Stéphan, F. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005174 · Cited by 24 · see citing works
Akoumianaki, E., Jonkman, A. H., Sklar, M. C., Georgopoulos, D., & Brochard, L. J. (2021) · Annals of Intensive Care · doi:10.1186/s13613-021-00897-3 · Cited by 21 · see citing works
Wilcox, S. R. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.09.018 · Cited by 21 · see citing works
Tao, W. Y., Yang, L., Gao, J., & Shao, J. (2018) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000002057 · Cited by 19 · see citing works
Nolan, J. P., Sandroni, C., Böttiger, B. W., Cariou, A., Cronberg, T., Friberg, H., Genbrugge, C., Haywood, K. L., Lilja, G., Moulaert, V. R. M., et al. (2021) · Notfall + Rettungsmedizin · doi:10.1007/s10049-021-00892-y · Cited by 20 · see citing works
Early Paralysis for the Management of ARDS
Grawe, E. S., Bennett, S., & Hurford, W. E. (2016) · Respiratory Care · doi:10.4187/respcare.04734 · Cited by 20 · see citing works
Baid, H. (2016) · Critical Care Nursing Clinics of North America · doi:10.1016/j.cnc.2016.07.005 · Cited by 19 · see citing works
Glucocorticoid therapy for acute respiratory distress syndrome: Current concepts
Zhao, Y., Yao, Z., Xu, S., Yao, L., & Yu, Z. (2024) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2024.02.002 · Cited by 20 · see citing works
Sedation strategies in children with pediatric acute respiratory distress syndrome (PARDS)
Rosenberg, L. M., & Traube, C. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.09.16 · Cited by 18 · see citing works
Advances in ventilator-associated lung injury: prevention is the target
Sutherasan, Y., D’Antini, D., & Pelosi, P. P. (2014) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2014.890519 · Cited by 19 · see citing works
Ming, Z., Gao, J., Zhang, X., Cui, Y., Fan, Z., & Ding, M. (2015) · Journal of Separation Science · doi:10.1002/jssc.201500092 · Cited by 18 · see citing works
Current Use of Neuromuscular Blocking Agents in Intensive Care Units
Tezcan, B., Turan, S., & Özgök, A. (2019) · Türk anesteziyoloji ve reanimasyon derneği dergisi · doi:10.5152/tjar.2019.33269 · Cited by 19 · see citing works
Standardized Management for Hypoxemic Respiratory Failure and ARDS
Parhar, K. K. S., Stelfox, H. T., Fiest, K. M., Rubenfeld, G. D., Zuege, D. J., Knight, G., Robertson, H. L., Soo, A., Doig, C. J., & Niven, D. J. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.05.611 · Cited by 17 · see citing works
Management of Acute Respiratory Failure in Patients With Hematological Malignancy
Vadde, R., & Pastores, S. M. (2015) · Journal of Intensive Care Medicine · doi:10.1177/0885066615601046 · Cited by 18 · see citing works
Wei, X., Wang, Z., Liao, X., Guo, W., Qin, T., & Wang, S.-H. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01637 · Cited by 15 · see citing works
Lee, S.-H., Yeo, H. J., Yoon, S. H., Lee, S. E., Cho, W. H., Jeon, D., Kim, Y. S., Son, B. S., & Kim, D. H. (2016) · Journal of Korean Medical Science · doi:10.3346/jkms.2016.31.6.932 · Cited by 15 · see citing works
Shao, S., Kang, H., & Tong, Z. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-037737 · Cited by 14 · see citing works
Mehta, S., Cook, D. J., Skrobik, Y. K., Muscedere, J., Martin, C. M., Stewart, T. E., Burry, L. D., Zhou, Q., & Meade, M. (2014) · Annals of Intensive Care · doi:10.1186/s13613-014-0033-9 · Cited by 15 · see citing works
Self-citationBauchlagerung von Patienten an der venovenösen ECMO ist möglich und sicher
Vöelker, M. T., Jahn, N., Bercker, S., Becker-Rux, D., Köppen, S., Kaisers, U. X., & Laudi, S. (2016) · Der Anaesthesist · doi:10.1007/s00101-015-0131-6 · Cited by 15 · see citing works
Santos, R. S., Silva, P. L., Rocco, J. R., Pelosi, P. P., & Rocco, P. R. M. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.06.76 · Cited by 15 · see citing works
A practical approach to the use of prone therapy in acute respiratory distress syndrome
Athota, K. P., Millar, D., Branson, R. D., & Tsuei, B. J. (2014) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2014.918850 · Cited by 13 · see citing works
Should Early Prone Positioning Be a Standard of Care in ARDS With Refractory Hypoxemia?
Marini, J. J., Josephs, S. A., Mechlin, M., & Hurford, W. E. (2016) · Respiratory Care · doi:10.4187/respcare.04562 · Cited by 13 · see citing works
Acute respiratory distress syndrome following cardiovascular surgery
Hoegl, S., Zwißler, B., Eltzschig, H. K., & Vohwinkel, C. U. (2015) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000283 · Cited by 13 · see citing works
Nolan, J. P., Soar, J., Cariou, A., Cronberg, T., Moulaert, V. R. M., Deakin, C. D., Böttiger, B. W., Friberg, H., Sunde, K., & Sandroni, C. (2017) · Notfall + Rettungsmedizin · doi:10.1007/s10049-017-0331-5 · Cited by 12 · see citing works
Zheng, Z., Jiang, L., Zhang, S., Guervilly, C., Zhang, M., Feng, X., & Ding, J. (2020) · Respiratory Research · doi:10.1186/s12931-020-1287-4 · Cited by 12 · see citing works
- Authors
- Alhazzani, W., Alshahrani, M., Jaeschke, R., Forel, J. M., Papazian, L., Sevransky, J., & Meade, M. O.
- Affiliations
- McMaster University Medical Centre (CA)
- Centre National de la Recherche Scientifique (FR)
- Johns Hopkins University (US)
- Corresponding author
- Alhazzani, Waleed
- Venue
- Critical Care
- Published
- 2013-03-11
- Volume
- 17
- Issue
- 2
- Pages
- R43-R43
- ISSN
- 1364-8535 (ISSN-L)
- PMC
- PMC3672502
- OpenAlex
- W2169283873
- Cited by
- 250
- References
- 32
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 21 · 2020: 42 · 2019: 22 · 2018: 15 · 2017: 30 · 2016: 31 · 2015: 24 · 2014: 14 · 2013: 7
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Critical Care (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Keywords
- neuromuscular blocking agents, acute respiratory distress syndrome, in-hospital mortality, barotrauma, ICU-acquired weakness, mechanical ventilation duration, critically ill adults
- MeSH terms
- Atracurium, Humans, Neuromuscular Blocking Agents, Respiration, Artificial, Respiratory Distress Syndrome, Randomized Controlled Trials as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review