Narcotic-based sedation regimens for critically ill mechanically ventilated patients
Open accessAbstract
Sedatives and analgesics are routinely used in the intensive care unit to relieve pain and anxiety. These agents have numerous side effects and may contribute to poor outcomes such as increased length of mechanical ventilation, longer ICU stays and acute and long-term cognitive dysfunction. Modifying sedation paradigms utilizing either narcotic-based regimens with remifentanil or fentanyl, or by using alpha2 agonists such as dexmedetomidine may help in improving these outcomes in critically ill patients.
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Critically ill patients often receive analgesics and sedatives for pain and anxiety, and these drugs are linked to a higher risk of delirium.
“Critically ill patients commonly receive analgesics and sedatives for management of pain and anxiety,5,6 and these medicines themselves are associated with an increased risk of delirium.”
From Feasibility of a virtual reality intervention in the intensive care unit (2021) · cites this paper as [6]
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Cites
Sessler, C. N., Gosnell, M. S., Grap, M. J., Brophy, G. M., O'Neal, P. V., Keane, K. A., Tesoro, E. P., & Elswick, R. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2107138 · Cited by 3,695 · see citing works
Ely, E. W., Inouye, S. K., Bernard, G. R., Gordon, S., Francis, J., May, L., Truman, B., Speroff, T., Gautam, S., Margolin, R., et al. (2001) · JAMA · doi:10.1001/jama.286.21.2703 · Cited by 3,210 · see citing works
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
Ely, E. W. (2004) · JAMA · doi:10.1001/jama.291.14.1753 · Cited by 3,073 · see citing works
Kress, J. P., Pohlman, A. S., O’Connor, M. F., & Hall, J. B. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422002 · Cited by 2,971 · see citing works
Jacobi, J., Fraser, G. L., Coursin, D. B., Riker, R. R., Fontaine, D. K., Wittbrodt, E. T., Chalfin, D. B., Masica, M. F., Bjerke, H. S., Coplin, W. M., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200201000-00020 · Cited by 1,892 · see citing works
Monitoring Sedation Status Over Time in ICU Patients
Ely, E. W., Truman, B., Shintani, A., Thomason, J. W. W., Wheeler, A. P., Gordon, S., Francis, J., Speroff, T., Gautam, S., Margolin, R. A., et al. (2003) · JAMA · doi:10.1001/jama.289.22.2983 · Cited by 1,704 · see citing works
Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation
Brook, A. D., Ahrens, T. S., Schaiff, R., Prentice, D., Sherman, G., Shannon, W. D., & Kollef, M. H. (1999) · Critical Care Medicine · doi:10.1097/00003246-199912000-00001 · Cited by 1,009 · see citing works
Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients
Riker, R. R., Picard, J. T., & Fraser, G. L. (1999) · Critical Care Medicine · doi:10.1097/00003246-199907000-00022 · Cited by 961 · see citing works
The Use of Continuous IV Sedation Is Associated With Prolongation of Mechanical Ventilation
Kollef, M. H., Levy, N. T., Ahrens, T. S., Schaiff, R., Prentice, D., & Sherman, G. (1998) · CHEST Journal · doi:10.1378/chest.114.2.541 · Cited by 916 · see citing works
Delirium in an intensive care unit: a study of risk factors
Dubois, M.-J., Bergeron, N., Dumont, M., Dial, S., & Skrobik, Y. (2001) · Intensive Care Medicine · doi:10.1007/s001340101017 · Cited by 609 · cited 1× · see citing works
“Unfortunately, benzodiazepines have numerous adverse effects, including the potential for prolonged ventilation, development of delirium and contribution to chronic cognitive dysfunction [3-7].”
BackgroundThe Relationship of Postoperative Delirium With Psychoactive Medications
Marcantonio, E. R. (1994) · JAMA · doi:10.1001/jama.1994.03520190064036 · Cited by 565 · see citing works
Inouye, S. K., Schlesinger, M. J., & Lydon, T. J. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00070-4 · Cited by 423 · see citing works
Rapid Development of Tolerance to Analgesia During Remifentanil Infusion in Humans
Vinik, H. R., & Kissin, I. (1998) · Anesthesia & Analgesia · doi:10.1097/00000539-199806000-00033 · Cited by 325 · see citing works
Samson, H. H., & Harris, R. A. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90065-e · Cited by 268 · see citing works
Breen, D., Karabinis, A., Malbrain, M. L. N. G., Morais, R. J., Albrecht, S., Jarnvig, I.-L., Parkinson, P., & Kirkham, A. J. T. (2005) · Critical Care · doi:10.1186/cc3495 · Cited by 234 · see citing works
Rapid Development of Tolerance to Analgesia During Remifentanil Infusion in Humans
Vinik, H. R., & Kissin, I. (1998) · Anesthesia & Analgesia · doi:10.1213/00000539-199806000-00033 · Cited by 225 · see citing works
Behavioral evidence for the involvement of γ-aminobutyric acid in the actions of ethanol
Martz, A., Dietrich, R. A., & Harris, R. A. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90607-6 · Cited by 223 · see citing works
Brattebø, G., Hofoss, D., Flaatten, H., Muri, A. K., Gjerde, S., & Plsek, P. E. (2002) · BMJ · doi:10.1136/bmj.324.7350.1386 · Cited by 218 · see citing works
Karabinis, A., Mandragos, K. E., Stergiopoulos, S., Komnos, A., Soukup, J., Speelberg, B., & Kirkham, A. J. T. (2004) · Critical Care · doi:10.1186/cc2896 · Cited by 200 · see citing works
&NA; (2001) · Survey of Anesthesiology · doi:10.1097/00132586-200104000-00011 · Cited by 141 · see citing works
The relationship of postoperative delirium with psychoactive medications
Marcantonio, E. R. (1994) · JAMA · doi:10.1001/jama.272.19.1518 · Cited by 93 · see citing works
Brattebø, G. (2004) · BMJ Quality & Safety · doi:10.1136/qhc.13.3.203 · Cited by 88 · see citing works
(2002) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/59.2.150 · Cited by 87 · see citing works
Cavaliere, F., Antonelli, M. M., Arcangeli, A., Conti, G., Costa, R., Pennisi, M. A., & Proietti, R. (2002) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03017909 · Cited by 66 · see citing works
Apitzsch, H., OLTHOFF, D., Thieme, V., Wiegel, M., Bohne, V., & Vetter, B. (1999) · Der Anaesthesist · doi:10.1007/s001010050705 · Cited by 14 · see citing works
Pandharipande, P. P., Shintani, A., Peterson, J. F., & Ely, W. (2004) · Critical Care Medicine · doi:10.1097/00003246-200412001-00075 · Cited by 8 · see citing works
[Experience with remifentanil in the ICU].
Bellis, P., Gerbi, G., Bacigalupo, P., Buscaglia, G., Massobrio, B., Montagnani, L., & Servidei, L. (2002) · PubMed · Cited by 7 · see citing works
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Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation
Ruokonen, E., Parviainen, I., Jakob, S. M., Nunes, S. L., Kaukonen, M., Shepherd, S. T., Sarapohja, T., Bratty, J. R., Takala, J. A., & For the “Dexmedetomidine for Continuous Sedation” Investigators (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1296-0 · Cited by 235 · see citing works
Feasibility of a virtual reality intervention in the intensive care unit
Jawed, Y. T., Golovyan, D., Lopez, D., Khan, S. H., Wang, S., Freund, C., Imran, S., Hameed, U. B., Smith, J. P., Kok, L., et al. (2021) · Heart & Lung · doi:10.1016/j.hrtlng.2021.05.007 · Cited by 65 · see citing works
Maksimow, A. T., Snapir, A., Särkelä, M. O. K., Kentala, E., Koskenvuo, J. W., Posti, J. P., Jääskeläinen, S. K., Hinkka‐Yli‐Salomäki, S., Scheinin, M., & Scheinin, H. (2006) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2006.01174.x · Cited by 54 · see citing works
The Sedation of Critically Ill Adults
Pun, B. T., & Dunn, J. (2007) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000279265.66906.2f · Cited by 54 · see citing works
Yaffe, P. B., Green, R. S., Butler, M. B., & Witter, T. (2015) · Journal of Intensive Care Medicine · doi:10.1177/0885066615618189 · Cited by 44 · see citing works
Chronic Pain and Chronic Opioid Use After Intensive Care Discharge – Is It Time to Change Practice?
Stamenković, D., Laycock, H. C., Καρανικόλας, Μ., Ladjevic, N. G., Nešković, V., & Bantel, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00023 · Cited by 45 · see citing works
Ethier, M. R., Mathews, K. A., Valverde, A., Kerr, C. L., Bersenas, A. M. E., Nykamp, S. G., & Davis, C. (2008) · American Journal of Veterinary Research · doi:10.2460/ajvr.69.10.1351 · Cited by 28 · see citing works
Dexmedetomidine for sedation and perioperative management of critically ill patients
Pandharipande, P. P., Ely, E. W., & Maze, M. (2006) · Seminars in Anesthesia Perioperative Medicine and Pain · doi:10.1053/j.sane.2006.01.001 · Cited by 21 · see citing works
Management of Sedation and Paralysis
Fierro, M. A., & Bartz, R. R. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.07.012 · Cited by 9 · see citing works
Rumpke, A. L., & Zimmerman, B. A. (2009) · Dimensions of Critical Care Nursing · doi:10.1097/dcc.0b013e3181be4bbf · Cited by 6 · see citing works
Becker, S. E. (2016) · Dimensions of Critical Care Nursing · doi:10.1097/dcc.0000000000000198 · Cited by 4 · see citing works
Bushuven, S., Kreuer, S., & Kranke, P. (2017) · AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie · doi:10.1055/s-0043-114676 · Cited by 1 · see citing works
Delirium, Sleep, and Mental Health Disturbances in Critical Illness
Pandharipande, P. P., Jackson, J. C., & Ely, E. W. (2008) · Elsevier eBooks · doi:10.1016/b978-032304841-5.50075-3
Exposure to Immersive Relaxing Virtual Environments for Hospitalized Patients
Pereira, M., Oliveira, P., Gomes, M. E., & de Sousa, S. (2023) · Advances in medical technologies and clinical practice book series · doi:10.4018/978-1-6684-9251-2.ch006
- Authors
- Pandharipande
- Venue
- Critical Care
- Published
- 2005
- Volume
- 9
- Issue
- 3
- Pages
- 247
- ISSN
- 1364-8535 (ISSN-L)
- PMC
- PMC1175895
- OpenAlex
- W1497351237
- Cited by
- 14
- References
- 25
- Citations by year
- 2023: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Critical Care (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vanderbilt University
- Geriatric Research Education and Clinical Center
- National Institute on Aging (K23AG001023, K23 AG-01023-01A1)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- sedation, remifentanil, fentanyl, dexmedetomidine, alpha-2 adrenergic agonists, mechanical ventilation, critically ill patients, analgesia, sedative side effects, cognitive impairment, ICU length of stay
- MeSH terms
- Remifentanil, Humans, Hypnotics and Sedatives, Intensive Care Units, Piperidines, Respiration, Artificial, Time Factors, Ventilator Weaning, Multicenter Studies as Topic, Procedural Sedation, Dexmedetomidine
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