The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
Open accessAbstract
DNA methylation is a chemical modification of cytosine bases that is pivotal for gene regulation,cellular specification and cancer development. Here, we describe an R package, methylKit, thatrapidly analyzes genome-wide cytosine epigenetic profiles from high-throughput methylation andhydroxymethylation sequencing experiments. methylKit includes functions for clustering, samplequality visualization, differential methylation analysis and annotation features, thus automatingand simplifying many of the steps for discerning statistically significant bases or regions of DNAmethylation. Finally, we demonstrate methylKit on breast cancer data, in which we find statisticallysignificant regions of differential methylation and stratify tumor subtypes. methylKit is availableat http://code.google.com/p/methylkit.
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The Sequence Alignment/Map format and SAMtools
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DNA methylation landscapes: Provocative insights from epigenomics
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Self-citationGenome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536
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Self-citationRestoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.032 · Cited by 707
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Metadata
- Authors
- Akalin, A., Kormaksson, M., Li, S., Garrett-Bakelman, F. E., Figueroa, M. E., Melnick, A., & Mason, C. E.
- Venue
- Genome Biology
- Published
- 2012-10-03
- Volume
- 13
- Issue
- 10
- Pages
- R87-R87
- ISSN
- 1465-6906 (ISSN-L)
- 1474-760X
- OpenAlex
- W2150194502
- Cited by
- 2,238
- References
- 14
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- Akalin, A., Kormaksson, M., Li, S., Garrett-Bakelman, F. E., Figueroa, M. E., Melnick, A., & Mason, C. E. (2012). methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biology. https://doi.org/10.1186/gb-2012-13-10-r87
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