The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dosage compensation is less effective in birds than in mammals
Open accessAbstract
Background: In animals with heteromorphic sex chromosomes, dosage compensation of sex-chromosome genes is thought to be critical for species survival. Diverse molecular mechanisms have evolved to effectively balance the expressed dose of X-linked genes between XX and XY animals, and to balance expression of X and autosomal genes. Dosage compensation is not understood in birds, in which females (ZW) and males (ZZ) differ in the number of Z chromosomes. Results: Using microarray analysis, we compared the male:female ratio of expression of sets of Z-linked and autosomal genes in two bird species, zebra finch and chicken, and in two mammalian species, mouse and human. Male:female ratios of expression were significantly higher for Z genes than for autosomal genes in several finch and chicken tissues. In contrast, in mouse and human the male:female ratio of expression of X-linked genes is quite similar to that of autosomal genes, indicating effective dosage compensation even in humans, in which a significant percentage of genes escape X-inactivation. Conclusion: Birds represent an unprecedented case in which genes on one sex chromosome are expressed on average at constitutively higher levels in one sex compared with the other. Sex-chromosome dosage compensation is surprisingly ineffective in birds, suggesting that some genomes can do without effective sex-specific sex-chromosome dosage compensation mechanisms.
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Cites
Tissue-specific expression and regulation of sexually dimorphic genes in mice
Yang, X., Schadt, E. E., Wang, S., Wang, H., Arnold, A. P., Ingram-Drake, L., Drake, T. A., & Lusis, A. J. (2006) · Genome Research · doi:10.1101/gr.5217506 · Cited by 922
Self-citationSkeletal muscle gene expression profiles in 20–29 year old and 65–71 year old women
Welle, S., Brooks, A. I., Delehanty, J. M., Needler, N., Bhatt, K., Shah, B., & Thornton, C. A. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.011 · Cited by 210 · cited 3×
“GDS472 contained data for 15 females and GDS287 listed data for 15 males.”
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Cited by
The evolution of sex-biased genes and sex-biased gene expression
Ellegren, H., & Parsch, J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2167 · Cited by 925
Genome analysis of the platypus reveals unique signatures of evolution
paper, A. L. O. A. A. T. A. A. A. T. E. O. T. (2008) · Nature · doi:10.1038/nature06936 · Cited by 719
Arnold, A. P., & Chen, X. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.001 · Cited by 587
Self-citationThe Number of X Chromosomes Causes Sex Differences in Adiposity in Mice
Chen, X., McClusky, R., Chen, J., Beaven, S. W., Tontonoz, P., Arnold, A. P., & Reue, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002709 · Cited by 326
Self-citationBurgoyne, P. S., & Arnold, A. P. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0115-5 · Cited by 154
Self-citationThe importance of having two X chromosomes
Arnold, A. P., Reue, K., Eghbali, M., Vilain, E., Chen, X., Ghahramani, N., Itoh, Y., Li, J., Link, J. C., Ngun, T., et al. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0113 · Cited by 114
Self-citationImpact of experience-dependent and -independent factors on gene expression in songbird brain
Drnevich, J., Replogle, K. L., Lovell, P., Hahn, T. P., Johnson, F., Mast, T. G., Nordeen, E., Nordeen, K., Strand, C., London, S. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200655109 · Cited by 57
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Metadata
- Authors
- Itoh, Y., Melamed, E., Yang, X., Kampf, K., Wang, S., Yehya, N., Van Nas, A., Replogle, K., Band, M. R., Clayton, D. F., Schadt, E. E., Lusis, A. J., & Arnold, A. P.
- Venue
- Journal of Biology
- Published
- 2007-03-22
- Volume
- 6
- Issue
- 1
- Pages
- 2-2
- ISSN
- 1475-4924 (ISSN-L)
- OpenAlex
- W2157457551
- Cited by
- 353
- References
- 2
- FWCI
- 16.75
- Type
- journal article
- Language
- en
- Open access
- gold
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