The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Epithelial antimicrobial peptides in host defense against infection
Open accessAbstract
One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs. Peptides of the defensin, cathelicidin, and histatin classes are found in humans. In the airways, alpha-defensins and the cathelicidin LL-37/hCAP-18 originate from neutrophils. beta-Defensins and LL-37/hCAP-18 are produced by the respiratory epithelium and the alveolar macrophage and secreted into the airway surface fluid. Beside their direct antimicrobial function, antimicrobial peptides have multiple roles as mediators of inflammation with effects on epithelial and inflammatory cells, influencing such diverse processes as proliferation, immune induction, wound healing, cytokine release, chemotaxis, protease-antiprotease balance, and redox homeostasis. Further, antimicrobial peptides qualify as prototypes of innovative drugs that might be used as antibiotics, anti-lipopolysaccharide drugs, or modifiers of inflammation.
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Cites
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Cited by
Dermcidin: A novel human antibiotic peptide secreted by sweat glands
Schittek, B., Hipfel, R., Sauer, B., Bauer, J., Kalbacher, H., Stevanovic, S., Schirle, M., Schroeder, K., Blin, N., Meier, F., et al. (2001) · Nature Immunology · doi:10.1038/ni732 · Cited by 730
Human Antimicrobial Peptides: Defensins, Cathelicidins and Histatins
De Smet, K., & Contreras, R. (2005) · Biotechnology Letters · doi:10.1007/s10529-005-0936-5 · Cited by 560
CAMP: a useful resource for research on antimicrobial peptides.
Thomas, S., Karnik, S., Barai, R. S., Jayaraman, V. K., & Idicula-Thomas, S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1021 · Cited by 462
Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458
Yin, K., Wang, Y., Zhao, H., Wang, D., Guo, M., Mu, M., Liu, Y., Nie, X., Li, B., Li, J., et al. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145758 · Cited by 438
Metadata
- Authors
- Bals, R.
- Venue
- Respiratory Research
- Published
- 2000-10-20
- Volume
- 1
- Issue
- 3
- Pages
- 141-50
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- DOI
- 10.1186/rr25
- OpenAlex
- W2098306468
- Cited by
- 498
- References
- 62
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
