Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease
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Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between sickle red blood cells (RBCs), white blood cells (WBCs) and/or platelets, and the vascular endothelium. One potential mechanism of vascular damage in ACS is by generation of oxygen-related molecules, such as superoxide (O2-), hydrogen peroxide (H2O2), peroxynitrite (ONOO-), and the hydroxyl (*OH) radical. The present review summarizes the evidence for alterations in oxidant stress during ACS of SCD, and the potential contributions of RBCs, WBCs and the vascular endothelium to this process.
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Sickle cells produce greater amounts of O2•−, H2O2, and hydroxyl radical •OH compared with healthy RBCs.
“It has been reported that sickle cells produce greater amounts of O2•−, H2O2, and hydroxyl radical •OH compared with healthy RBCs (8, 80, 100).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [100]
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- Authors
- Klings, E. S., & Farber, H. W.
- Affiliations
- Boston University (US)
- Corresponding author
- Klings, Elizabeth S
- Venue
- Respiratory Research
- Published
- 2001-07-13
- Volume
- 2
- Issue
- 5
- Pages
- 280-5
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- DOI
- 10.1186/rr70
- PMC
- PMC59517
- OpenAlex
- W2171650346
- Cited by
- 132
- References
- 64
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 4
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Respiratory Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- OpenBU (Boston University) (submittedVersion)
- Funders
- American Heart Association
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- acute chest syndrome, sickle cell disease, free radicals, oxidative stress, superoxide, hydrogen peroxide, peroxynitrite, hydroxyl radicals, vascular occlusion, sickle red blood cells, leukocytes, platelets, vascular endothelium
- MeSH terms
- Anemia, Sickle Cell, Animals, Antioxidants, Erythrocytes, Free Radicals, Humans, Leukocytes, Thorax, Oxidants
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