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Cited by 9Cancer-related Molecular PathwaysCancer-related molecular mechanisms researchGastric Cancer Management and Outcomes

SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms

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Wang, Tairan, Jin, Yan, Wang, Mengyao, Chen, Boya, Sun, Jinyu, Zhang, Jiaying, Yang, Hui, Deng, Xinyao +3 more·2024·Molecular Medicine
DOI 10.1186/s10020-024-00812-zPMC PMC11000312
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Abstract

Effective therapeutic targets and early diagnosis are major challenges in the treatment of gastrointestinal tract (GIT) cancers. SALL4 is a well-known transcription factor that is involved in organogenesis during embryonic development. Previous studies have revealed that SALL4 regulates cell proliferation, survival, and migration and maintains stem cell function in mature cells. Additionally, SALL4 overexpression is associated with tumorigenesis. Despite its characterization as a biomarker in various cancers, the role of SALL4 in GIT cancers and the underlying mechanisms are unclear. We describe the functions of SALL4 in GIT cancers and discuss its upstream/downstream genes and pathways associated with each cancer. We also consider the possibility of targeting these genes or pathways as potential therapeutic options for GIT cancers.

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Authors
Wang, T., Jin, Y., Wang, M., Chen, B., Sun, J., Zhang, J., Yang, H., Deng, X., Cao, X., Wang, L., & Tang, Y.
Affiliations
  • Henan Medical University (CN)
  • Zhengzhou University (CN)
Corresponding author
  • Wang, Lidong
  • Tang, Yuanyuan
ORCID
Venue
Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2024-04-08
Volume
30
Issue
1
Pages
46-46
ISSN
  • 1076-1551 (ISSN-L)
  • 1528-3658
DOI
10.1186/s10020-024-00812-z
PMC
PMC11000312
OpenAlex
W4394575350
Cited by
9
References
165
Citations by year
2026: 2 · 2025: 6 · 2024: 1
FWCI
0.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • the Opening Project of the State Key Laboratory of Esophageal Cancer Prevention and Treatment (K2022-007)
  • the College Students' Innovation and Entrepreneurship Training Programs of Henan Province (202210472030)
  • the Doctoral Research Fund Program of Xinxiang Medical University (YBSKYZZ202004)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
Keywords
SALL4, gastrointestinal cancer, transcription factors, cell proliferation, cell migration, stem cell function, carcinogenesis, biomarkers, therapeutic target, signaling pathways
MeSH terms
Gastrointestinal Neoplasms, Humans, Stem Cells, Transcription Factors, Cell Line, Tumor, Embryonic Development

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