Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies

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Molecular subgroups of medulloblastoma: the current consensus

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Medulloblastoma Comprises Four Distinct Molecular Variants

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Intertumoral Heterogeneity within Medulloblastoma Subgroups

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The whole-genome landscape of medulloblastoma subtypes

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Phase III Study of Craniospinal Radiation Therapy Followed by Adjuvant Chemotherapy for Newly Diagnosed Average-Risk Medulloblastoma

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Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial

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Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

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Subgroup-specific structural variation across 1,000 medulloblastoma genomes

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Dissecting the genomic complexity underlying medulloblastoma

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Postoperative Chemotherapy and Delayed Radiation in Children Less Than Three Years of Age with Malignant Brain Tumors

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Novel mutations target distinct subgroups of medulloblastoma

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Subtypes of medulloblastoma have distinct developmental origins

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Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

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Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

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Metastasis Stage, Adjuvant Treatment, and Residual Tumor Are Prognostic Factors for Medulloblastoma in Children: Conclusions From the Children's Cancer Group 921 Randomized Phase III Study

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Treatment of Early Childhood Medulloblastoma by Postoperative Chemotherapy Alone

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PVT1 dependence in cancer with MYC copy-number increase

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Transport of drugs across the blood–brain barrier by nanoparticles.

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Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

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Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

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Medulloblastoma can be Initiated by Deletion of patched in Lineage-Restricted Progenitors or Stem Cells

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Genomics Identifies Medulloblastoma Subgroups That Are Enriched for Specific Genetic Alterations

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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma

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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

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Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

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Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade

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Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

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A constitutively active epidermal growth factor receptor cooperates with disruption of G 1 cell-cycle arrest pathways to induce glioma-like lesions in micePreprint

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice

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Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study

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Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma

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A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

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Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

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Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery

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Drug and gene targeting to the brain with molecular trojan horses

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β-Catenin Status Predicts a Favorable Outcome in Childhood Medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee

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Getting into the brain: liposome-based strategies for effective drug delivery across the blood&amp;ndash;brain barrier

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Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

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Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

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Active medulloblastoma enhancers reveal subgroup-specific cellular origins

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Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

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Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

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Advantage of protons compared to conventional X-ray or IMRT in the treatment of a pediatric patient with medulloblastoma

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BET Bromodomain Inhibition of MYC -Amplified Medulloblastoma

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Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype

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Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial

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Divergent clonal selection dominates medulloblastoma at recurrence

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MRI Surrogates for Molecular Subgroups of Medulloblastoma

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An Animal Model of MYC-Driven Medulloblastoma

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Cytogenetic Prognostication Within Medulloblastoma Subgroups

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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

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Effects of Medulloblastoma Resections on Outcome in Children: A Report from the Children's Cancer Group

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Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

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Low-Stage Medulloblastoma: Final Analysis of Trial Comparing Standard-Dose With Reduced-Dose Neuraxis Irradiation

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Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

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A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma

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Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

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Medulloblastoma in childhood: new biological advances

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Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children

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Drugging MYCN through an Allosteric Transition in Aurora Kinase A

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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC- Driven Medulloblastoma

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