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Validation of the Generalized Anxiety Disorder-7 (GAD-7) and GAD-2 in patients with migraine
Open accessAbstract
BACKGROUND: Psychiatric problems have been commonly reported in patients with migraine. This study investigated the reliability and validity of the Generalized Anxiety Disorder-7 (GAD-7) and Generalized Anxiety Disorder-2 (GAD-2) in patients with migraine. METHODS: Subjects were recruited from a headache clinic and a neuropsychologist examined their GAD using the Mini International Neuropsychiatric Interview-Plus Version 5.0.0 (MINI). Subjects completed several instruments, including the GAD-7, the Beck Anxiety Inventory (BAI), the Migraine Disability Assessment Scale (MIDAS), the Headache Impact Test-6 (HIT-6), and the Migraine-Specific Quality of Life (MSQoL). RESULTS: Among 146 participants, 32 patients (21.9 %) had GAD as determined by the MINI. Cronbach's α for the GAD-7 and GAD-2 were 0.915 and 0.820, respectively. At a cutoff score of 5, the GAD-7 had a sensitivity of 78.1 %, a specificity of 74.6 %, a positive predictive value (PPV) of 46.3 %, and a negative predictive value (NPV) of 92.4 %. At a cutoff score of 1, the GAD-2 had a sensitivity of 84.4 %, a specificity of 72.8 %, a PPV of 46.6 %, and a NPV of 94.3 %. The scores of the GAD-7 and GAD-2 well correlated with the BAI score, the MIDAS score, the HIT-6 score, and the MSQoL score. CONCLUSIONS: The GAD-7 and GAD-2 are both reliable and valid screening instruments for GAD in patients with migraine.
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“The GAD-7 has shown strong internal consistency (Cronbach’s α = 0.92) [57] and is validated for chronic pain patients with migraine [58].”
From ACTsmart: Guided Smartphone-Delivered Acceptance and Commitment Therapy for Chronic Pain—A Pilot Trial. (2021) · cites this paper as [58]
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Metadata
- Authors
- Seo, J.-G., & Park, S.-P.
- Affiliations
- Kyungpook National University (KR)
- Corresponding author
- Park, Sung-Pa
- Venue
- The Journal of Headache and Pain
- Published
- 2015-11-23
- Volume
- 16
- Issue
- 1
- Pages
- 97-97
- ISSN
- 1129-2369 (ISSN-L)
- 1129-2377
- PMC
- PMC4656257
- OpenAlex
- W2173864200
- Cited by
- 341
- References
- 30
- Citations by year
- 2026: 40 · 2025: 36 · 2024: 53 · 2023: 46 · 2022: 36 · 2021: 49 · 2020: 26 · 2019: 25 · 2018: 19 · 2017: 3 · 2016: 8
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Journal of Headache and Pain (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Nursing › Research and Theory › Health Education and Validation
- Keywords
- Generalized Anxiety Disorder-7, GAD-2, generalized anxiety disorder, migraine, anxiety screening, psychometric validation, reliability statistics, sensitivity and specificity, migraine disability, migraine-related quality of life, headache impact
- MeSH terms
- Adolescent, Adult, Aged, Anxiety Disorders, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Migraine Disorders, Psychiatric Status Rating Scales, Psychometrics, Sensitivity and Specificity, Reproducibility of Results, Comorbidity, Young Adult
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